External preparation containing pantethine phosphate ester
A technology of pantethine phosphate and external preparations, applied to medical preparations containing active ingredients, skin care preparations, organic active ingredients, etc., can solve problems such as odor, strong, and inability to add external preparations, and achieve Improves the effect of whitening activity
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Embodiment 1
[0082] Example 1 (pantethine-4', 4"-barium diphosphate, pantethine and pantetheine -S-calcium sulfonate pH stability comparison)
[0083] Each buffer (pH3-9.5) containing 0.1% (w / v) pantethine-4', 4"-barium diphosphate was prepared at 50 mM. Sodium citrate buffer was used as pH3, 4, 5 and 6. Buffer. Sodium phosphate buffer was used as the buffer of pH 6.5 and 7. Tris-HCl buffer was used as the buffer of pH 8 and 9.5. 0.4 mL of pantethine- Each solution of 4', 4"-barium diphosphate was sealed in a 1 mL glass ampoule and heated at 40°C for 6 months. The samples before and after heating were analyzed by HPLC to determine the content of pantethine-4', 4"-diphosphate. The same operation was also carried out for the same concentration of pantethine and pantetheine-S-calcium sulfonate , compare the result ( figure 1 ).
[0084] As a result, there was no difference in the stability of pantethine-4',4"-diphosphate, pantethine, and pantethein-S-calcium sulfonate at pH 5 to 6. Th...
Embodiment 2
[0085] Example 2 (pantethine-4', 4"-diphosphate, pantethine-4'-phosphate and pantethine pH Stability Comparison of Amines)
[0086] Prepare 50 mM of each buffer (pH3-9.5) containing 0.1% (w / v) pantethine-4', 4"-sodium diphosphate. Sodium citrate buffer was used as the buffer of pH3, 4, 5 and 6 solution. Use sodium phosphate buffer as the buffer solution with pH 7. Use Tris-HCl buffer solution as the buffer solution with pH 8 and 9.5. Seal 0.4 mL of each solution into a 1 mL glass ampoule and heat at 40°C for 3 months .The samples before and after heating were analyzed by HPLC to determine the content of pantethine-4',4"-diphosphoric acid. The same operation is also carried out for pantethine and pantethine-4'-phosphoric acid of the same concentration, and the results are compared ( figure 2 ).
[0087] As a result, there was no difference in the stability of pantethine, pantethine-4'-phosphate, and pantethine-4',4"-diphosphate at pH 5 to 6. However, at pH In the pH reg...
Embodiment 3
[0088] Example 3 (pantethine-4', 4 "-two-α-glucoside, pantethine-4'-α-glucose glycosides and pantethine stability comparison)
[0089] Prepare 50mM sodium citrate buffer solution (pH3~9.5) containing 0.1% (w / v) pantethine-4', 4"-di-α-glucoside. Use sodium citrate buffer solution as pH3, 4, 5 and 6 buffers. Use sodium phosphate buffer as the buffer at pH 7. Use Tris-HCl buffer as the buffer at pH 8 and 9.5. Seal 0.4 mL of each solution into a 1 mL glass ampoule and store at 40°C Heated for 6 months. The samples before and after heating were analyzed by HPLC to measure the content of pantethine-4', 4 "-di-α-glucoside. The same operation is also carried out for pantethine-4'-α-glucoside and pantethine of the same concentration, and the results are compared ( image 3 ).
[0090] There was no difference in the stability of pantethine-4',4"-di-α-glucoside, pantethine-4'-α-glucoside, and pantethine at pH 5 to 6 However, in the pH region where the pH is below 4 or the pH is ab...
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