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Method for preparing sinomenine hydrochloride infusion solutions and freeze-dried powder injections

A technology of sinomenine hydrochloride and freeze-dried powder injection, which is applied in the direction of freeze-dried transportation, anti-inflammatory agents, pharmaceutical formulations, etc., can solve the problem of high cancer production rate, achieve high purity, reduce the processing process, and be conducive to environmental protection Effect

Active Publication Date: 2012-07-25
HUNAN ZHENGQING PHARM GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(Chen Yukun's "Chinese Medicine Extraction Technology", 1992), the existing methods all use very toxic benzene or chloroform as the extraction solvent, and benzene is a first-class toxic solvent with a high carcinogenesis rate, which has been banned in the pharmaceutical industry, and in The recovery and treatment of solvents requires a very complicated process to meet environmental protection requirements, and chloroform is a secondary toxic reagent, so benzene and chloroform solvents should be avoided as much as possible in the extraction of traditional Chinese medicine

Method used

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  • Method for preparing sinomenine hydrochloride infusion solutions and freeze-dried powder injections
  • Method for preparing sinomenine hydrochloride infusion solutions and freeze-dried powder injections
  • Method for preparing sinomenine hydrochloride infusion solutions and freeze-dried powder injections

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0038] Experimental example 1: Study on the extraction process of Qingfengteng non-organic solvent

[0039] 1. Experimental method

[0040] 1.1 Materials and Instruments

[0041] Qingfengteng crude powder, macroporous adsorption resin, sinomenine hydrochloride reference substance, hydrochloric acid, ammonia water, sodium hydroxide, ethanol, sodium chloride, etc.

[0042] Glass column (diameter 3cm, height 30-40cm), HPLC high-performance liquid phase detector, rotary evaporator.

[0043] 1.2 Methods and results

[0044] 1.2.1 Judgment method

[0045] (1) Selection of alkaloid indicator

[0046] Prepare three alkaloid indicators, bismuth potassium iodide dilute solution, alkaline potassium ferricyanide, and silicotungstic acid test solution, according to the method in Part One of the Chinese Pharmacopoeia 2010 edition, and take 1 to 2 drops respectively in the test solution for precipitation, The color reaction, compared with previous experiments, shows that the indication ...

Embodiment 1

[0104] Embodiment one: a kind of preparation method of sinomenine hydrochloride big infusion, the method comprises the steps:

[0105] A. Extraction: 500kg of Qingfengteng coarse powder, wet with 500L of 0.5mol / L HCl for 3 hours, install the percolation cylinder, add 0.5mol / L HCl to make the liquid surface cover the powder by 2cm, soak for 12 hours, press Start percolation at a speed of 3ml / min, stop percolation after 12 hours, obtain percolation liquid, and set aside;

[0106] B. Column elution: Put the treated cation exchange resin or 152 type resin on the percolation liquid, the ratio of diameter to height is 1:10, and the sample loading speed is 3 times the column volume / hour, until the effluent is tested with silicotungstic acid If there is precipitation in the liquid inspection, stop loading the sample when there is no alkaloid spot detected by thin-layer chromatography, and stop when the eluent is eluted with purified water until the eluent has no color, soak the resin ...

Embodiment 2

[0109] Embodiment two: a kind of preparation method of sinomenine hydrochloride big infusion, this method comprises the steps:

[0110] A. Extraction: 800kg of Qingfengteng coarse powder, wet it with 1000L of 0.9mol / L HCl for 5 hours, install the percolation cylinder, add 0.9mol / L HCl to make the liquid surface cover the powder by 2cm, after soaking for 20 hours, press Start percolation at a speed of 5ml / min, stop percolation after 24 hours, obtain percolation liquid, and set aside;

[0111] B. Column elution: put the treated cation exchange resin 001*4 type or 152 type resin on the percolation liquid, the ratio of diameter to height is 1:10, and the loading speed is 5 times the column volume / hour, until the effluent is used If there is precipitation in the silicotungstic acid test solution, stop loading the sample when there is no alkaloid spot detected by thin-layer chromatography, and stop when the eluent is colorless by elution with purified water, soak the resin with 10% ...

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Abstract

The invention discloses a method for preparing sinomenine hydrochloride infusion solutions and freeze-dried powder injections. The method disclosed by the invention adopts adsorption technique of cation exchange resin or macroporous adsorption resin to replace traditional benzene extraction and chloroform extraction technique that are more toxic, and is high in extraction rate and simpler in operation; and harm and pollution to operators and the environment produced by the large-quantity high-toxicity organic solvent can be overcame, the method reduces processes for treating the organic solvent, is more beneficial for environmental protection, reduces investment in environmental protection facilities of plants, and is beneficial for environment-friendly production. Sinomenine hydrochloride extracted and separated by the method disclosed by the invention is used as a raw material in pharmaceutical preparations, has higher purity and no residual solvent, and reduces the potential hazards to human body.

Description

technical field [0001] The present invention relates to a preparation method of sinomenine hydrochloride large infusion and freeze-dried powder injection, in particular to a non-organic solvent extraction of active ingredient sinomenine hydrochloride in Caulis chinensis to prepare sinomenine hydrochloride large infusion and freeze-dried powder injection method. Background technique [0002] Qingfengteng is a traditional Chinese medicine commonly used in traditional Chinese medicine. It is the dry cane of Fangjiaceae plants Qingteng and Ivy twig. Meridian, urination effect, used to treat rheumatic arthralgia, joint swelling, numb itching, anti-arrhythmia and antihypertensive effects. [0003] The main components in C. chinensis are alkaloids. The components that have been found so far are Sinomenine, Igoginomenine, SinoAcutine, Acutumidine, and Acutumine. Sinaetine and Diginomenine, Ethylsinomenine, Sinactine, Tetrahydroepiperberine, Bat Pueroline, Bat Ge Ning, Tetrahydrop...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/19A61K31/485A61K31/473A61P29/00C07D221/18C07D221/28
Inventor 吴飞驰仇萍文迎艺滕健许李董绍象彭祖仁王小伟
Owner HUNAN ZHENGQING PHARM GRP CO LTD
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