Method for synthesizing o-methyl formate benzene sulfonamide

Abstract

The invention relates to a method for synthesizing o-methyl formate benzene sulfonamide which is capable of effectively solving the problems that a conventional o-methyl formate benzene sulfonamide synthesizing method is complex in process, high in cost, low in efficiency and pollutes environment and comprises the steps of: heating water, adding sodium nitrite, dissolving, and adding methyl o-aminobenzoate to obtain a methyl ester mixture; putting the water in a diazo pot, adding sulfuric acid and hydrochloric acid to obtained mixed acid; reducing the temperature of the mixed acid, adding the methyl ester mixture, reacting to obtain a diazonium salt solution, adding copper sulfate, introducing sulfur dioxide, determining by utilizing an H acid reagent solution and fading by utilizing the H acid; adding toluene, introducing liquid chlorine, determining to be darkgreen by utilizing a benzidine reagent solution, standing and layering to obtain an o-methyl formate benzene sulfonamide solution at the upper layer; and adding anhydrous toluene and carbinol, introducing liquid ammonia, adjusting pH (potential Of Hydrogen) value to be neutral by using acetic acid, removing the acetic acid, washing till being colourless by using the toluene, removing the toluene, beating by using the water, washing to be neutral, removing the water and drying. The method disclosed by the invention has the advantages of easiness in operation, high efficiency, low cost and good quality, and saves energy and raw material, and is environment-friendly.

Description

technical field [0001] The invention relates to chemical industry, in particular to a method for synthesizing methyl o-formate benzenesulfonamide (also known as methanesulfonamide). Background technique [0002] Methyl o-formate benzenesulfonamide (methylsulfonamide) is an important pesticide and pharmaceutical intermediate, mainly used in the synthesis of sulfonylurea herbicides. Among them, there is a class of products such as sulfonylurea herbicides such as chlorimsulfuron-methyl, sulfasulfuron-methyl, flurimsulfuron-methyl, propoxysulfuron-methyl, metsulfuron-methyl, tribenuron-methyl, metsulfuron-methyl and other varieties of sulfonylurea herbicides and methyl-o-formate It is one of the main raw materials for the synthesis of the above herbicides. Its traditional synthesis method is obtained by esterification of o-benzoylsulfonimide (saccharin) and methanol. The method is to obtain methyl o-formate benzenesulfonyl chloride, aminate it with ammonia water to form an amin...

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Problems solved by technology

[0003] For above-mentioned situation, in order to overcome the defective of prior art, the object of the present invention provides a kind of method of synthesizing methyl o-formate benzene sulfonamide, can effectively solve the complex production process of o-methyl o-formate benzene sulfonamide, high cost, low efficiency and the problem of polluting the environment

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