Star-shaped cationic polymer containing dendriform polylysine element and preparation method thereof
A cationic polymer, polylysine base unit technology, applied in the field of biomedical engineering materials, to achieve the effect of reducing cytotoxicity, low metabolite toxicity, and single molecular weight distribution
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Embodiment 1
[0055] a. Weigh triphenylphosphine and dissolve it in anhydrous N, N-dimethylformamide (DMF), then add iodine element at room temperature at 25°C, raise the temperature to 55°C; then add dry β-cyclopaste Fine (β-CD), N 2 Reaction under atmosphere for 48 hours; after the reaction, anhydrous N,N-dimethylformamide was removed by distillation under reduced pressure, and sodium methoxide solution was added under ice-water bath conditions; the resulting product was precipitated 7 times in methanol, and then vacuum-dried to obtain seven (6-iodo-6-deoxy)-β-cyclodextrin [β-CD-(I) 7 ]; the molar ratio of the β-cyclodextrin, triphenylphosphine and iodine simple substance is 1: 1.2: 1.4; the anhydrous N, N-dimethylformamide is added with 20 grams of dry Beta-cyclodextrin meter; the molar number of sodium methylate in the sodium methylate solution is 1.5 times of the dry beta-cyclodextrin molar number;
[0056] b. Dissolve the hepta(6-iodo-6-deoxy)-β-cyclodextrin and sodium azide obtaine...
Embodiment 2
[0058] a. Weigh triphenylphosphine and dissolve it in anhydrous N,N-dimethylformamide (DMF), then add iodine element at room temperature at 35°C, and raise the temperature to 70°C; then add dry β-cyclopaste Fine (β-CD), N 2 Reaction under atmosphere for 24 hours; after the reaction, anhydrous N, N-dimethylformamide was distilled off under reduced pressure, and sodium methoxide solution was added under ice-water bath conditions; the resulting product was precipitated 4 times in methanol, and then vacuum-dried to obtain seven (6-iodo-6-deoxy)-β-cyclodextrin [β-CD-(I) 7 ]; the molar ratio of the β-cyclodextrin, triphenylphosphine and iodine simple substance is 1: 1.5: 1.6; the anhydrous N, N-dimethylformamide is added 5 grams of dry Beta-cyclodextrin meter; the molar number of sodium methylate in the sodium methylate solution is 2.0 times of the dry beta-cyclodextrin molar number;
[0059] b. Dissolve the hepta(6-iodo-6-deoxy)-β-cyclodextrin and sodium azide obtained in step a ...
Embodiment 3
[0061] a. Weigh triphenylphosphine and dissolve it in anhydrous N,N-dimethylformamide (DMF), then add iodine element at room temperature at 5°C, and raise the temperature to 60°C; then add dry β-cyclopaste Fine (β-CD), N 2 Reaction under atmosphere for 32 hours; after the reaction, anhydrous N,N-dimethylformamide was removed by distillation under reduced pressure, and sodium methoxide solution was added under ice-water bath conditions; the resulting product was precipitated in methanol for 6 times, and then dried in vacuum to obtain seven (6-iodo-6-deoxy)-β-cyclodextrin [β-CD-(I) 7 ]; the molar ratio of the β-cyclodextrin, triphenylphosphine and iodine simple substance is 1: 1.3: 1.5; the anhydrous N, N-dimethylformamide is added with 15 grams of dry Beta-cyclodextrin meter; the molar number of sodium methylate in the sodium methylate solution is 1.8 times of the dry beta-cyclodextrin molar number;
[0062] b. Dissolve the hepta(6-iodo-6-deoxy)-β-cyclodextrin and sodium azid...
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