Isoflavone compound, its preparation method, and its application in preparation of antiviral or antitumor drugs

A compound and selected technology can be used in anti-tumor drugs, anti-viral agents, active ingredients of heterocyclic compounds, etc., and can solve problems such as increasing difficulty, increasing investment in research and development, and prolonging the time for research and development of new drugs.
CN102617536AInactive Publication Date: 2012-08-01SHANGHAI RUIGUANG BIOCHEM TECH DEV +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI RUIGUANG BIOCHEM TECH DEV
Publication Date
2012-08-01
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to an isoflavone compound, its preparation method, and its application in the preparation of antiviral or antitumor drugs, and concretely relates to a compound with a structural formula represented by formula (I). In the formula (I), R1 is hydrogen or C1-6 alkyl; X is -O-, -NH-, -CH=CH-, or ethinyl, or R2 is directly connected with benzopyran; R2 is selected from substituted or unsubstituted phenyl, substituted or unsubstituted heteroaryl, C1-16 alkyl, C1-16 alkyloxy, C1-16 alkyloxycarbonyl, or substituted or unsubstituted benzoyloxy; the heteroaryl is selected from groups derived from a five or six-membered heterocycle or a fused heterocycle containing one or two hetero atoms of N, O or S, and is selected but not limited to pyridyl, benzopyridyl, or groups derived from phenoxathiin, thiophene, oxazole and benzopyridine; and above substituent is selected from halogen, cyan, nitro, hydroxy, amino, C1-6 monosubstituted or disubstituted amino, C1-16 alkyl, halogenated C1-6 alkyl, C2-6 alkenyl, C6-12 arylalkenyl, C1-16 alkyloxy, C1-16 carboxyl, C1-16 alkyloxycarbonyl, C1-16 alkylcarbonyl, and substituted or unsubstituted phenoxyl. The invention also provides the preparation of the compound.
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Description

technical field

[0001] The present invention relates to the field of medicinal chemistry. The present invention particularly relates to a class of isoflavone compounds with antiviral and antitumor activities. The present invention also relates to the preparation method of such compounds. The present invention also relates to the use of such compounds in the preparation of therapeutic antiviral or Application in antitumor drugs. Background technique

[0002] Malignant tumor is a common and frequently-occurring disease that seriously threatens human health. The mortality rate caused by malignant tumors is the second highest among all diseases, second only to cardiovascular and cerebrovascular diseases. Tumor treatment methods include surgery, radiation therapy, and drug therapy (chemotherapy), but chemotherapy is still the main method to a large extent.

[0003] Antineoplastic drugs refer to drugs against malignant tumors, that is, anticancer drugs. Since nitrogen mustard wa...

Claims

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