Synthesis method of dye intermediate

The technology of a dye intermediate and a synthesis method is applied in the field of preparation of the dye intermediate, and can solve the problems of easy decomposition of methyl chloroacetate recovery, large proportion of methyl chloroacetate, difficulty in recovery and reuse, and the like, so as to eliminate the need for distillation and recovery. Process, production environment improvement, avoid the effect of storage perishable
CN102633666AInactive Publication Date: 2012-08-15HANGZHOU JIHUA JIANGDONG CHEMICAL CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
HANGZHOU JIHUA JIANGDONG CHEMICAL CO LTD
Publication Date
2012-08-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the technical field of dye. In order to solve the problem that the methyl chloroacetate N-alkylation reaction in the existing preparation process of -CH2COOCH3-containing substituted aniline dye intermediate is large in required methyl chloroacetate proportion, hard to recycle, easy to deteriorate during storing and the like, the invention provides a synthesis method of dye intermediate, i.e. a synthesis method of dye intermediate shown in the general formula (I), comprising the following steps of: taking substituted aniline shown in the general formula (II) as a raw material, adding water aqua, methyl chloroacetate, catalyst sodium bromide and acid-binding agent, pulping and heating to reflow and divide water, and carrying out the N-alkylation reaction, so that the dye intermediate is prepared. After the method in the invention is adopted, the consumption of methyl chloroacetate can be greatly reduced, the methyl chloroacetate distillation recovery working procedure can be eliminated, and the problem that the recovered methyl chloroacetate is easy to decompose can be avoided.
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Description

technical field

[0001] The invention relates to the technical field of dyes, in particular to a preparation method of a dye intermediate. Background technique

[0002] Contains -CH 2 COOCH 3 Substituted anilines are widely used as a class of important dye intermediates, and the commonly used preparation process is to use a large amount of methyl chloroacetate to carry out N-alkylation synthesis in the presence of an acid agent (such as soda ash). Methyl chloroacetate is not only used as a reaction solvent, but also as an alkylating agent and a water-carrying agent, and is used in a large amount. During double N-alkylation, the molar mass ratio of it to the raw material sometimes needs to reach more than 5:1. Methyl chloroacetate is relatively toxic and has a stimulating effect on all tissues of the human body. It is harmful to the body after inhalation, ingestion, and percutaneous absorption. Simultaneously, the use of a large amount of methyl chloroacetate will inevitabl...

Claims

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