Anti-adsorption and long-circulation lipid molecule, preparation method and application thereof in fields of medicines and cosmetics

A molecular and lipid technology, applied in the field of phospholipids as a pharmaceutical carrier material, can solve problems such as difficulty in meeting multiple modifications
CN102653573AActive Publication Date: 2012-09-05INST OF PROCESS ENG CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
INST OF PROCESS ENG CHINESE ACAD OF SCI
Publication Date
2012-09-05

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Abstract

The invention relates to a lipid molecule, namely poly-carboxyl oxyneurine (R1-L-PCB), which is represented by the formula (I), and a preparation method and application thereof. The method for preparing the R1-L-PCB comprises the following steps of: reacting the lipid molecule with halogenated hydrocarbon to obtain R1-L-X, (II) for short; and then with the R1-L-X as an initiator and carboxyl oxyneurine CB as a monomer, performing polymerization reaction on an atom transfer radical to obtain the R1-L-PCB, (I) for short. The R1-L-PCB lipid molecule derivate has high nonspecific protein adsorption resistance performance, can be used in nonspecific protein adsorption of a liposome, is favorable for improving the stability and the transferring efficiency of the liposome and can be applied to the fields of medicines, cosmetics and the like.
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Description

technical field

[0001] The invention relates to a pharmaceutical carrier material phospholipid, in particular, the invention relates to a lipid molecule-polycarboxybetaine, its preparation method and its application. Background technique

[0002] Liposome is a molecular orderly assembly formed spontaneously by phospholipids in water by hydrophobic association, and is a multilamellar vesicle structure. Liposomes have the advantages of good biocompatibility, low toxicity, and low immune response. At present, liposomes are used to encapsulate hydrophobic drugs, hydrophilic drugs and genetic drugs, etc. After intravenous injection, liposomes can effectively delay drug release and improve bioavailability, and are widely used in the fields of medicine and cosmetics.

[0003] During blood circulation, liposomes are prone to non-specific adsorption with serum proteins, forming large-sized aggregates, which are easily cleared by the mononuclear phagocyte system (MPS), resulting in s...

Claims

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