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3,5-dyhydroxyl-4-isopropyl diphenylethene chitosan gel and preparation method thereof

A technology of isopropyl stilbene and chitosan gel, which is applied to the active ingredients of hydroxyl compounds, antifungal agents, and pharmaceutical formulations, and can solve problems such as affecting the efficacy of the drug, uneven dispersion, and local precipitation of the drug. , to achieve the effect of increasing the ability of drug absorption, improving water solubility and stability, and mild reaction conditions

Inactive Publication Date: 2012-09-12
HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The method usually used in the preparation of general gels is: dissolve the drug in a solvent and directly attach it to the carrier matrix. During the preparation process, since some carrier matrixes need to add a large amount of water to swell, those poorly water-soluble substances may The drug is partially precipitated and cannot be evenly dispersed on the carrier matrix, which affects the efficacy of the drug
[0007] At present, there is no report on 3,5-dihydroxy-4-isopropyl stilbene chitosan gel in China

Method used

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  • 3,5-dyhydroxyl-4-isopropyl diphenylethene chitosan gel and preparation method thereof
  • 3,5-dyhydroxyl-4-isopropyl diphenylethene chitosan gel and preparation method thereof
  • 3,5-dyhydroxyl-4-isopropyl diphenylethene chitosan gel and preparation method thereof

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Embodiment 1

[0058] Example 1 A preparation method of 3,5-dihydroxy-4-isopropyl stilbene chitosan gel

[0059] The specific operation process of this embodiment is as follows:

[0060] Take 25g of 3,5-dihydroxy-4-isopropyl stilbene, 80g of glycerin, 50g of lecithin, and 0.5g of cholesterol, add it to 300g of ethanol, stir and dissolve at a dissolution temperature of 50°C, and then add it to 400g of sterilized In deionized water, shear 3 times in a high-shear homogenizer to make a uniform emulsion;

[0061] then lowered to room temperature;

[0062] Add 15g of chitosan and stir evenly; add 20g of laurocaprazine and stir evenly, then slowly add 10g of triethanolamine dropwise to adjust the pH to 6.0, after stirring fully, add 200g of sterilized deionized water at a speed of 1200rpm Stir to complete the initial mixing, and then transfer to a homogenizer for homogeneous mixing to obtain the product 3,5-dihydroxy-4-isopropyl stilbene chitosan gel.

[0063] The in vitro transdermal release ...

Embodiment 2—5

[0065] Embodiment 2-5 is respectively a kind of 3,5-dihydroxyl-4-isopropyl stilbene chitosan gel and preparation method thereof, the difference of their formula consumption and concrete operation process and embodiment 1 is only Because: the types, dosages and reaction conditions of the active ingredients involved are different, and the specific data are shown in Table 3.

[0066]

[0067] The preparation method of 3,5-dihydroxyl-4-isopropyl stilbene chitosan gel in embodiment 2-5 is carried out according to the following steps respectively:

[0068] Add 3,5-dihydroxy-4-isopropyl stilbene, glycerin, lecithin, and cholesterol into the solvent, stir and dissolve at the corresponding temperature, and then add about two-thirds of the total amount of sterilized In ionized water, shear 3 times in a high-shear homogenizer to make a uniform emulsion and obtain nanoemulsion;

[0069] then lowered to room temperature;

[0070] Add chitosan to the nanoemulsion and stir evenly; add a...

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Abstract

The invention discloses a 3,5-dyhydroxyl-4-isopropyl diphenylethene chitosan gel and a preparation method thereof. The preparation method for the gel comprises the following steps of: emulsifying 3,5-dyhydroxyl-4-isopropyl diphenylethene taken as an active ingredient, lecithin and cholesterol under the combined action of a solvent and dispersing in deionized water uniformly; and preparing the 3,5-dyhydroxyl-4-isopropyl diphenylethene chitosan gel by taking chitosan as a main auxiliary material and by using glycerol, a transdermal accelerating agent and a gel. The 3,5-dyhydroxyl-4-isopropyl diphenylethene chitosan gel has the characteristics of high stability, skin penetrability, film-forming performance and adhesion. According to the method, the medicines are prepared into nano-emulsion, and the nano-emulsion is adsorbed to the chitosan so as to prepare the chitosan gel. The method has the characteristics of simplicity of operation, mild reaction condition and the like; and transdermal experiments indicate that the penetrable capacity of the 3,5-dyhydroxyl-4-isopropyl diphenylethene chitosan gel is improved by 70 times compared with the 12-hour penetrable capacity of crude medicines. The prepared 3,5-dyhydroxyl-4-isopropyl diphenylethene chitosan gel can be used for treating psoriasis, atopic dermatitis and the like.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a chitosan gel and a preparation method thereof, in particular to a 3,5-dihydroxy-4-isopropylstilbene chitosan gel and its preparation method. Preparation. Background technique [0002] 3,5-Dihydroxy-4-isopropyl stilbene (drug name: Benzenemod) has good antifungal properties and can be used to treat intractable psoriasis and other diseases. The existing dosage form of the medicine is mainly cream, which has the disadvantages of high oiliness, easy shedding, difficult cleaning and inconvenient use. [0003] Gel is an external dosage form of drugs, which is suitable for skin, mucous membranes and cavities. It not only avoids the first-pass effects of enzymes and acids in the gastrointestinal tract that exist in oral administration, but also reduces the toxic and side effects of drugs. The concept of "external treatment of diseases". In general, transdermal absorption enh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/05A61K47/36A61P31/10A61P17/06
Inventor 张越魏爽
Owner HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY