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Process for preparing polysucrose

A process method, polysucrose technology, which is applied in the field of compound preparation, can solve the problems of insufficient yield and purity of polysucrose, and achieve the effects of short reaction process, mild reaction conditions, and improved yield and purity

Active Publication Date: 2014-07-02
ADANA FOOD TECH LIUZHOU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a process for preparing polysucrose, which can prepare polysucrose under milder conditions, and solve the problem that the yield and purity of polysucrose in the prior art are not high enough

Method used

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  • Process for preparing polysucrose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 80g sucrose, 24ml (ie 24g) distilled water, 40g epibromopropane were loaded into a device with a ceramic film thickness of 2cm loaded with D201 resin, and reacted at 25°C for 2 hours, and the pH value of the reaction was 12, so that the mixture was Polymerization was carried out on a strong basic anion exchange resin, the temperature was raised to 60° C., and the reaction was continued for 2 hours, and then the reaction solution was eluted with distilled water, and the product low-cross-linked polysucrose was adsorbed on the resin. The product was purified with acetone, and the low-cross-linked polysucrose was eluted and fractionated with absolute ethanol, and the selected low-cross-linked polysucrose had a weight-average molecular weight of 300,000.

[0015] In a 250ml three-necked flask equipped with a stirring device, add 5g of low-cross-linked polysucrose, 20ml of distilled water, and 3ml of epibromopropane, and fully stir to mix them uniformly. 3 ml of Span 85 was ...

Embodiment 2

[0017] In a 250ml three-necked flask with a stirring device, add 5g of the low-crosslinked polysucrose prepared in Example 1, 20ml of distilled water, and 4ml of epibromopropane, and fully stir to mix them uniformly. 3 ml of Tween 85 was added to 150 ml of chlorobenzene to the mixture, and the pH was adjusted to 13 with aqueous sodium hydroxide solution. Then, the water bath was reacted at 70°C for 1.5 hours, and a large number of microspheres appeared. After curing at 90°C for 9.5 hours, the product was filtered and washed with absolute ethanol and distilled water for several times to obtain transparent spherical particles, which were dried, and the yield was 95.9%. %.

Embodiment 3

[0019] In a 250ml three-necked flask with a stirring device, add 5g of the low-crosslinked polysucrose prepared in Example 1, 20ml of distilled water, and 4ml of epibromopropane, and fully stir to mix them uniformly. 4.2 ml of Span 85 was added to 150 ml of liquid paraffin and added to the mixture, and the pH was adjusted to 12 with aqueous sodium hydroxide solution. Then the water bath was reacted at 75°C for 1.5 hours, and a large number of microspheres appeared. After curing at 95°C for 10 hours, the product was filtered and washed with absolute ethanol and distilled water for several times to obtain transparent spherical particles, which were dried, and the yield was 94.6%. %.

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Abstract

The invention discloses a process for preparing polysucrose. The process includes following steps: placing sucrose, distilled water and epibromohydrin after mixing into a device loaded with strong-base anion exchange resin; subjecting the mixture to polymerization reaction on the strong-base anion exchange resin at the temperature of 25 DEG C to 30 DEG C, heating to 60 DEG C to 65 DEG C for re-reaction, eluting the product after the reaction with the distilled water, and absorbing low cross-linked polysucrose of the product on the resin; purifying the product with acetone, and subjecting the purified product to graded eluting with anhydrous ethanol and selecting proper low cross-linked polysucrose; mixing the proper low cross-linked polysucrose with the distilled water and the epibromohydrin, dissolving dispersant into oil phase to be added to the mixture, adjusting the pH of the system with sodium hydroxide solution, performing water bath heating reaction, heating and solidifying; and filtering the obtained product and repeatedly washing with the anhydrous ethanol and the distilled water to get transparent polysucrose granule. The process for preparing the polysucrose is simple, easy to implement and higher in reaction activity, so that productivity and purity of the polysucrose are improved.

Description

technical field [0001] The invention relates to the technical field of compound preparation, in particular to a process method for preparing a water-soluble polymer. Background technique [0002] Polysucrose is a typical sucrose polymer, which is a water-soluble white powdery polymer with a particle size of about 10 nanometers in solution, and can be stored at room temperature. According to its molecular weight, it is divided into: 800 polysucrose, 400 polysucrose, 200 polysucrose, 100 polysucrose, 70 polysucrose, 10 polysucrose. Its endogenous viscosities were: 24.5, 17, 12, 8, 7, 2.5 cp. Polysucrose has the characteristics of good biocompatibility, high reactivity, and good water solubility, and is currently mainly used in the field of cell separation. And because of its good performance, it has great application potential in the field of protein adsorption, tissue engineering, and immunology research. [0003] At present, the synthesis methods of sucrose-based polymer...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00C08J3/24
Inventor 邱新荣金琼曹慧赟
Owner ADANA FOOD TECH LIUZHOU
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