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Electrically conductive macromolecular nano-material and application of electrically conductive macromolecular nano-material

A technology of conductive polymers and nanomaterials, applied in the direction of wave energy or particle radiation treatment materials, medical preparations containing active ingredients, organic dyes, etc., to achieve simple preparation methods, good optical absorption properties, and remarkable effects

Inactive Publication Date: 2012-10-03
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are no reports on the application of poly(3,4-ethylenedioxythiophene) / polystyrenesulfonic acid in biomedicine, especially in optical absorption

Method used

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  • Electrically conductive macromolecular nano-material and application of electrically conductive macromolecular nano-material
  • Electrically conductive macromolecular nano-material and application of electrically conductive macromolecular nano-material
  • Electrically conductive macromolecular nano-material and application of electrically conductive macromolecular nano-material

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Example 1: Preparation of PEG-modified PEDOT:PSS conductive polymer nanomaterials:

[0035] Such as figure 1 As shown, the preparation of PEG-modified polymer nanomaterials based on PEDOT:PSS, through the interaction between charges, self-assemble PAH, PAA and PEG polymers layer by layer, specifically includes the following steps:

[0036] (1) Using commercial PEDOT:PSS as the starting material (CLEVIOS PH1000), take 5mL of PEDOT:PSS polymer solution (1mg / mL), put it into a dialysis bag with a molecular weight of 14000 for 24h, change the water every 5h, and finally Get 10 mL of PEDOT:PSS solution and store it in a 4°C refrigerator for later use. Characterization (dynamic light scattering and zeta potential) is then performed.

[0037](2) Take 4mL PAH (MW=14000~16000) polymer solution (1mg / mL) in a serum bottle, and slowly add 4mL of the dialyzed PEDOT:PSS polymer solution (0.5 mg / mL) dropwise under ultrasonic conditions. mL). Continue to sonicate for 0.5 h after t...

Embodiment 2

[0041] Example 2: fluorescent dye Cy5 labeled PEDOT:PSS conductive polymer nanomaterial

[0042] Take 4 mL of PEDOT:PSS-PEG polymer solution (0.5 mg / mL) in a serum bottle, slowly add fluorescent labeling molecule Cy5, and add 20 mg of EDC, adjust the pH to 7.4, and stir for 12 hours. After the reaction is over, wash three times with an ultrafiltration tube (molecular weight 10KD) to remove excess reaction by-products such as Cy5, EDC, and PBS. Concentrate to 4 mL to obtain Cy5-labeled PEDOT:PSS polymer solution (0.5 mg / mL), that is, PEDOT:PSS-PEG-Cy5. Then, characterization (UV absorption and fluorescence) was performed.

[0043] The result is as Figure 5 as shown, Figure 5 (a) is the UV absorption spectrum of Cy5-labeled PEDOT:PSS. It can be seen that there is still very good optical absorption in the near-infrared region (600-1000 nanometers), and there is a very obvious absorption at 660 nanometers, which is mainly due to the fact that Cy5 is connected to the PEDOT:PS...

Embodiment 3

[0044] Example 3: Blood circulation time of Cy5-labeled conductive polymer PEDOT:PSS in vivo

[0045] Blood circulation behavior test of Cy5-labeled conductive polymer PEDOT:PSS injected into mice through tail vein: Cy5-labeled conductive polymer PEDOT:PSS was injected into mice through tail vein, the injection dose was 10mg / kg, according to About 10 μl of fresh blood was taken from the mouse vein at different time points, weighed and dissolved in 400 μl of blood lysate (1% SDS, 1% Triton-100, 40mM Tris buffer solution). Measure the blood circulation time of PEDOT:PSS in the body.

[0046] The result is as Figure 6 As shown, the blood circulation curve fits the second-order model. The first half-life time is: (t 1 / 2 )=4.75 ± 2.21 min (t 1 / 2 ), the second half-life time is: (t 1 / 2 ’)= 99.63 ± 15.28 min (t 1 / 2 '). After 48 hours, a relatively strong Cy5-labeled PEDOT:PSS fluorescence signal was still observed in the blood, which provided an opportunity for the nanomateri...

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Abstract

The invention discloses an electrically conductive macromolecular nano-material and an application of the electrically conductive macromolecular nano-material. According to the electrically conductive macromolecular nano-material, poly (3, 4-ethylidene dioxythiophene) / poly styrene sulfonic acid is taken as a substrate, wherein nano-particles formed by modifying polyacrylamide hydrochloride, polyacrylic acid and polyethylene glycol on the poly (3, 4-ethylidene dioxythiophene) / poly styrene sulfonic acid layer by layer. The nano-material is further connected with some fluorescent dyes or chemical drugs. The electrically conductive macromolecular nano-material can prepare photo-thermal therapeutic agent for treating cancer. The electrically conductive macromolecular nano-material has very strong optical absorption property in near-infrared area, forms a superbly high enrichment on the tumour position in the way of caudal vein injection and has very good treating effect under exposure to laser.

Description

technical field [0001] The invention relates to a polymer nano material, in particular to a conductive polymer material with good absorption in the near-infrared region, and its application as a photothermal treatment agent. Background technique [0002] Cancer is one of several major malignant diseases that threaten human health in the 21st century. Although a large amount of human, material and financial resources have been invested in the prevention and treatment of cancer for decades since the 1950s, the progress made by human beings in this regard is still very limited. [0003] Recently developed photothermal therapy has attracted more and more attention. The main principle is that some substances with good light absorption will generate high heat under laser irradiation after being swallowed by cells, which can kill tumor cells. Because near-infrared light has a strong ability to penetrate human tissues, the main components of human tissues such as water have poor a...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K49/00A61P35/00C08J7/12C08L65/00C08L25/18C09B69/10
Inventor 刘庄程亮
Owner SUZHOU UNIV
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