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Resin type ointment with higher drug release performance and its preparation method and application

A resin-type and ointment technology, which is used in pharmaceutical formulations, medical preparations with non-active ingredients, and ointment delivery, etc., can solve the problems of poor drug release performance and strong adhesiveness of resin-type ointments, and achieve moderate adhesion performance, The effect of good drug release and high drug release performance

Active Publication Date: 2016-02-10
NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the advantages of resin type ointment, it has attracted widespread attention, but resin type ointment has strong adhesion and poor drug release performance.

Method used

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  • Resin type ointment with higher drug release performance and its preparation method and application
  • Resin type ointment with higher drug release performance and its preparation method and application
  • Resin type ointment with higher drug release performance and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] 1. Preparation of resin paste

[0049]

[0050] With the raw material of above-mentioned quality, proceed as follows:

[0051] 1. Add thermoplastic elastomer SIS, plasticizer, and 50% antioxidant into the reactor, blow nitrogen for 5 minutes to remove the air, heat up to the mixture melts, and at the same time pass nitrogen protection, control the temperature between 120°C and 150°C, and stir , until the mixture forms a uniform and transparent viscous colloid.

[0052] 2. Put the tackifying resin and the remaining 50% of the antioxidant into the above mixture, control the temperature between 100°C and 110°C, stir for half an hour, and at the same time pass nitrogen protection until the mixture forms a uniform and transparent viscoelastic colloid.

[0053] 3. Cool the above colloid to below 100°C and pour it out.

[0054]2. Preparation of joint pain relief ointment

[0055] 1. make the Chinese medicine resin ointment with the above-mentioned method of embodiment 1;...

Embodiment 2

[0095] 1. Preparation of resin paste

[0096]

[0097] Prepared according to the above composition ratio, the method is the same as in Example 1.

[0098] 2. Preparation of joint pain relief ointment: Repeat the method of Example 1, the difference being that the matrix prepared in Example 1 is replaced with the resin ointment matrix prepared in Example 2.

[0099] 3. Product testing:

[0100] The initial viscosity, persistent viscosity, peeling strength, drug loading and drug release performance of the joint pain ointment prepared in Example 2 were investigated. Method is with embodiment 1. The test results are shown in Tables 4, 5, 6 and image 3 , Figure 4 .

[0101] Table 4

[0102]

[0103] The results in Table 4 show that the plaster prepared in Example 2 has moderate sticking force, peel strength between 1N and 2N, and good air permeability.

[0104] Table 5 affects the drug release of camphor in the patch

[0105]

[0106] Table 5 and image 3 The res...

Embodiment 3

[0111] 1. Preparation of resin paste:

[0112]

[0113] With the raw material of above-mentioned quality, proceed as follows:

[0114] 1. Add thermoplastic elastomer SIS, plasticizer, and 50% antioxidant into the reactor, blow nitrogen for 5 minutes to remove air, heat up until the mixture melts, and at the same time pass nitrogen protection, control the temperature between 120°C and 150°C, and stir , until the mixture forms a uniform and transparent viscous colloid.

[0115] 2. Put the tackifying resin and 50% antioxidant into the above mixture, control the temperature between 100°C and 110°C, stir for half an hour, and at the same time pass nitrogen protection until the mixture forms a uniform and transparent viscoelastic colloid; then add Fillers and organic acids, stir to disperse evenly;

[0116] 3. Cool the above colloid to below 100°C and pour it out.

[0117] 2. Preparation of joint pain relief ointment

[0118] 1. make the Chinese medicine resin ointment with t...

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Abstract

The invention discloses a resin ointment with high drug release. The resin ointment comprises the following components, by weight: 35%-50% of a thermoplastic elastomer SIS; 8%-30% of a tackifying resin selected from rosin resin, terpene resin, C5 petroleum resin, hydrogenated petroleum resin or random combinations thereof; 25%-45% of a plasticizer selected from liquid paraffin, Twain 80, dibutyl phthalate, lanolin, castor oil, naphthenic oil or random combinations thereof; 1%-3% of an antioxidant and / or an anti-aging agent selected from microcrystalline wax, propyl gallate, rubber accelerator or random combinations thereof; 0-24% of a filler selected from zinc oxide and titanium oxide; and 0-10% of an organic acid selected from citric acid and tartaric acid. In addition, the present invention also discloses the preparation method of the resin ointment and application thereof to a traditional Chinese medicine plaster product. The resin ointment of the invention has good skin initial tack, moderate peeling strength, no stimulation, good air permeability, high drug release performance and good compatibility with medicine.

Description

technical field [0001] The invention relates to a medical ointment, in particular to a resin type ointment; in particular, it relates to a resin type ointment with high drug release performance; in addition, the invention also relates to a preparation method of the resin type ointment. Background technique [0002] In the traditional transdermal administration of traditional Chinese medicine, natural rubber is mainly used as the adhesive layer matrix. This kind of rubber ointment is a plaster made by mixing the medicinal material extract with the matrix, and then coating it on the backing material. Traditional rubber pastes are prone to allergies because they contain natural rubber; in addition, organic solvents are added during production, resulting in organic solvent residues, which are irritating to the skin, and rubber pastes have poor air permeability, causing skin irritation and allergic reactions. Rubber paste requires a large amount of gasoline in production, which ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K9/70A61K47/44A61K47/32
Inventor 汤秀珍张皓王承潇杜晨捷樊敏伟
Owner NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE
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