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Pyrimorph oil suspending agent and preparation method thereof

A technology of fenpyrroline oil and fenpyrroline, which is applied in the field of fenpyril oil suspension and its preparation, can solve problems such as easy degradation, poor stability, and operator hazards, and achieve a beneficial effect on drug production. Effective, good bactericidal effect, easy to measure the effect

Inactive Publication Date: 2012-10-24
山东亿嘉农化有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the stability of fenpyroline in the water suspension is not good, and it is easy to degrade and thus affect the drug effect. Although the oil suspension has good stability, due to the use of heterocyclic and aromatic hydrocarbon organic solvents during preparation, it will It will bring some pollution to the environment, and it will also cause some harm to the operator when using it.
Powder formulations are more inconvenient to use than emulsion formulations

Method used

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  • Pyrimorph oil suspending agent and preparation method thereof
  • Pyrimorph oil suspending agent and preparation method thereof
  • Pyrimorph oil suspending agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] (1) Measure the following raw materials according to weight percentage: 10% pyrimorph, 5% emulsifier alkyl sulfonate, 2% dispersant polymeric carboxylate, 3% synergist clove oil, suspending agent organic bentonite 2%, 0.2% preservative sorbitol stearic acid, replenish 100% with organic continuous phase pine ester base vegetable oil, standby;

[0044] (2) Put the organic continuous phase in a mixing tank, add the emulsifier and dispersant while stirring, and mix for 5 minutes;

[0045](3) Add the fenpyroline under stirring condition, and stir for 5 minutes;

[0046] (4) Slowly add the suspending agent under stirring conditions, and stir for 10 minutes until uniform;

[0047] (5) The mixed material obtained in step (4) is sanded by a sand mill, and then put into a homogenizer;

[0048] (6) Put the synergist and preservative into the homogenizer, start the homogenizer, homogenize for 15 minutes, stop, and obtain the finished fenpyrroline oil suspension.

Embodiment 2

[0050] (1) Measure the following raw materials according to weight percentage: 40% pyrimorph, 7% emulsifier dibenzylphenol polyoxyethylene ether, 2% dispersant naphthalenesulfonate, 3% synergist perilla oil, anti-corrosion Agent sodium benzoate 0.2%, suspending agent white carbon black 2%, make up 100% with organic continuous phase methyl oleate, standby;

[0051] (2) Put the organic continuous phase in a mixing tank, add the emulsifier and dispersant while stirring, and mix for 4 minutes;

[0052] (3) Add the fenpyroline under stirring condition, and stir for 4 minutes;

[0053] (4) Slowly add the suspending agent under stirring conditions, and stir for 12 minutes until uniform;

[0054] (5) The mixed material obtained in step (4) is sanded by a sand mill, and then put into a homogenizer;

[0055] (6) Put the synergist and preservative into the homogenizer, start the homogenizer, homogenize for 15 minutes, stop, and obtain the finished fenpyrroline oil suspension.

Embodiment 3

[0057] (1) Measure the following raw materials according to the weight percentage: 95% of the active ingredient pyrimorph is converted to 15%, and the emulsifier uses 7% of TERMUL1284 produced by the Huntsman Group of the United States and 6% of Nongru 1602# Mixture, dispersant use 3% TERMUL5500 that U.S. Huntsman Group produces, synergist clove oil 5%, suspending agent organic bentonite 2%, make up 100% with organic continuous phase pine ester base vegetable oil, standby;

[0058] (2) Put the organic continuous phase in a mixing tank, add the emulsifier and dispersant while stirring, and mix for 5 minutes;

[0059] (3) Add the fenpyroline under stirring condition, and stir for 3 minutes;

[0060] (4) Slowly add the suspending agent under stirring conditions, and stir for 12 minutes until uniform;

[0061] (5) The mixed material obtained in step (4) is sanded by a sand mill, and then put into a homogenizer;

[0062] (6) Put the synergist and preservative into the homogenizer...

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Abstract

The invention discloses a pyrimorph oil suspending agent and a preparation method of the pyrimorph oil suspending agent. The pyrimorph oil suspending agent comprises the following components by weight: 5-7% of pyrimorph, 0.5-15% of emulsifier, 0.5-5% of dispersing agent, 0-5% of synergist, 0.1-5% of suspending agent and the balance of organic continuous phase which is supplemented to 100%. According to the oil suspending agent prepared by mixing the components, the vegetable fat in the organic continuous phase and the crude drug are effectively combined, so the affinity of the oil suspending agent and the plant leaves is strengthened; exertion of the pharmaceutical effect is more facilitated; and the storage stability is good and the pyrimorph oil suspending agent is not easily decomposed. Therefore, the pyrimorph oil suspending agent is high and lasting in pharmaceutical effect, good in sterilizing effect and free from three-waste pollution, and belongs to green and environment-friendly products and processes.

Description

technical field [0001] The invention relates to a pesticide preparation, in particular to a pyrimorph oil suspension and a preparation method thereof. Background technique [0002] Pyramorph is a fungicide specific for oomycetes. Its action is characterized by affecting the formation of cell wall membrane and inhibiting cell respiration. It is particularly sensitive to the formation stage of oomycete sporangia and oospores. Fungi of the Peronobacteriaceae and Phytophthora genus have unique modes of action. If the drug is administered before sporulation, sporulation can be completely inhibited. The results of activity studies show that this is a new type of fungicide with high efficiency and broad spectrum. Toxicology studies show that its toxicity is very low. Environmental toxicology studies have shown that pyrimorph has low toxicity to bees, quails, zebrafish, silkworms, Daphnia magna, and algae obliquus. The preparation also has low toxicity to bees, birds, fish and si...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/84A01N25/04A01P3/00
Inventor 李云王晓红韩金栋褚爱玲
Owner 山东亿嘉农化有限公司