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Traditional Chinese medicine preparation for treating liver-depression qi-stagnation type viral myocarditis and preparation method thereof

A technology for viral myocarditis and liver stagnation and qi stagnation type, which is applied in the field of traditional Chinese medicine preparations for the treatment of liver stagnation and qi stagnation type viral myocarditis and the field of preparation thereof, so as to achieve the effects of nourishing the myocardium, saving the lives of patients, and protecting heart cells.

Inactive Publication Date: 2012-11-14
吴彩霞 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a Chinese medicine preparation for the treatment of viral myocarditis and a preparation method thereof. There are still many deficiencies in the current medicines for the treatment of viral myocarditis. Long, side effects, curative effect is not exact, and difficult to adhere to, traditional Chinese medicine treatment methods have no special treatment of traditional Chinese medicine, there is no effective experience in clinical prescription, can only be added or subtracted according to the clinical experience of each doctor; and the taste of medicine is relatively strong Many, most of them are taken orally in decoction, and there is no injection form of traditional Chinese medicine, which is inconvenient to use and the medicine takes effect slowly

Method used

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  • Traditional Chinese medicine preparation for treating liver-depression qi-stagnation type viral myocarditis and preparation method thereof
  • Traditional Chinese medicine preparation for treating liver-depression qi-stagnation type viral myocarditis and preparation method thereof
  • Traditional Chinese medicine preparation for treating liver-depression qi-stagnation type viral myocarditis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0054] The preparation method of tablet of the present invention: add Radix Pseudostellariae 1500g, Salvia miltiorrhiza 1500g, Astragalus 1500g, Bupleurum 1500g, Gardenia 1300g, Forsythia 1500g, Rehmannia glutinosa 1500g, Guizhi 1200g, Ligustrum lucidum 1500g, Hedyotis diffusa 1500g, 1500g of Ophiopogon japonicus, 1500g of safflower, 1500g of white peony, 1500g of notoginseng, 1500g of Zhiwu, 1000g of poria, 1500g of loofah, 1500g of chuanxiong, 1500g of curcuma, 1500g of scutellaria, 1500g of Albizia julibrissin, 1500g of silkworm, 1500g of angelica, cypress Kernel 1500g; add 10 times the amount of ethanol, heat and reflux for extraction 3 times, each time for 2 hours, combine the 3 extracts, recover ethanol under reduced pressure and concentrate until the concentration of the medicinal solution is 0.5g crude drug / mL, after suction filtration, the filtrate The relative density is about 1.08 (20°C); the above-mentioned filtrate is eluted with deionized water or distilled water ...

experiment example 1

[0058] Experimental example 1: acute toxicity test of the present invention

[0059] 1. Test materials:

[0060] Animals: Kunming mice, weighing 21-24g, half male and half male, bred by the biological laboratory of Shandong University. Medicine: tablet of the present invention, containing 0.0365g crude drug / sheet

[0061] 2. Method:

[0062] 1. Calculation of LD50: Using the improved Cole's method, the mice were randomly divided into 5 groups, 10 in each group, half male and half male, and the tablet was dissolved in distilled water to make the maximum concentration, and administered according to the maximum allowable volume of the mice. Dosing is followed by 18, 14.4, 11.5, 9.2, 7.4 (g.kg-1) according to the crude drug amount, and after the animal is fasted (can't help water) for 18 hours, it is divided into two administrations (interval half an hour) in one day, 0.5ml each time, observe the animal death.

[0063] 2. Determination of maximum tolerated dose (MTD value): ta...

experiment example 2

[0066] Experimental example 2: Cumulative toxicity test:

[0067] Traditional Chinese medicine preparation of the present invention is taken orally honey refined pills to mice by 7.69, 19.18 and 43.21g crude drug / kg continuous medication 15 weeks (1.0ml / 100g body weight, every day 2 times) and after drug withdrawal 3 weeks, the result shows: Chinese medicine of the present invention The preparation has no obvious effect on the hair, behavior, defecation, body weight, organ weight, blood picture, liver and kidney function, blood sugar, blood lipid and other indicators of rats. After 1 week and 3 weeks after stopping the drug, there was no significant change in the organs of the rats. It shows that the oral capsule of the traditional Chinese medicine preparation of the present invention has little toxicity to rats after long-term administration, and there is no abnormal reaction after drug withdrawal, so the application is safe.

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Abstract

The invention provides a traditional Chinese medicine preparation for treating liver-depression qi-stagnation type viral myocarditis. The traditional Chinese medicine preparation comprises the following components in parts by weight: 10-20 parts of radix bupleuri, 10-20 parts of cape jasmine, 10-20 parts of fructus forsythiae, 10-20 parts of radix pseudostellariae, 10-20 parts of prepared rehmannia root, 10-20 parts of cassia twig, 10-20 parts of fructus ligustri lucidi, 10-20 parts of oldenlandia diffusa, 10-20 parts of radix ophiopogonis, 10-20 parts of the root of red-rooted salvia, 10-20 parts of carthamus tinctorius, 10-20 parts of radix paeoniae alba, 10-20 parts of pseudo-ginseng, 10-20 parts of astragalus mongholicus, 10-20 parts of prepared fleece flower root, 10-20 parts of poria cocos, 10-20 parts of vegetable sponge, 10-20 parts of ligusticum wallichii, 10-20 parts of curcuma zedoary, 10-20 parts of scutellaria baicalensis, 10-20 parts of albizia julibrissin, 10-20 parts of silkworm larva, 10-20 parts of angelica sinensis, and 10-20 parts of platycladi seeds. The traditional Chinese medicine preparation disclosed by the invention is capable of rapidly in-flowing blood, directly achieving myocardium and rapidly increasing myocardial contraction force and has the main functions of detoxifying, removing stasis, clearing heat, opening the inhibited lung-energy and clearing away the heart-fire; in addition, the functions of tonifying qi and calming the mind and the functions of soothing the liver and reducing heat are combined, the functions of rapidly relieving patient conditions and saving lives of patients are achieved.

Description

technical field [0001] The invention relates to a medical preparation containing components derived from plants, animals or minerals, in particular to a traditional Chinese medicine preparation for treating liver depression and qi stagnation type viral myocarditis and a preparation method thereof. Background technique [0002] In medical research, it can be found that the causes of myocarditis can be divided into: viruses, bacteria, fungi or parasites, and external conditions such as physical and chemical factors can cause myocarditis. Myocarditis refers to myocardial localized or diffuse acute or chronic inflammatory disease, which can be divided into two categories: infectious and non-infectious. Infectious myocarditis can be caused by viruses, bacteria, spirochetes, rickettsia, molds, protozoa, and worms. Non-infectious myocarditis includes allergic or allergic myocarditis, such as rheumatism and myocarditis caused by physical and chemical factors or drugs. The symptoms ...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P31/12A61P9/00
Inventor 刘冰甜
Owner 吴彩霞
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