Composite medicine and ointment for hemostasis and preparation methods of composite medicine and ointment
A technology for compounding medicaments and ointments, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, blood diseases, etc., can solve problems such as fast, safe, effective, rare, unable to achieve hemostatic effect, adverse consequences, etc., and achieve good hemostasis effect. , The effect of promoting automatic blood coagulation and preventing infection
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[0024] A preparation method of compound medicament for hemostasis:
[0025] (1) Weigh 0.01-0.02g phytohemagglutinin, 0.2-0.5g chitosan, and mix well;
[0026] (2) Add the above mixture into 10-30ml of distilled water and stir evenly to prepare a compound medicine.
[0027] A preparation method of composite ointment for hemostasis:
[0028] (1) Weigh 0.01-0.02g phytohemagglutinin, 0.2-0.5g chitosan, and mix well;
[0029] (2) Weigh 1.5-3g sodium carboxymethyl cellulose as a film-forming material, melt it into a colloidal liquid in 10-30ml of distilled water, add the mixture in step (1) to the colloidal liquid in step (2) and stir evenly to prepare Get compound ointment.
[0030] See Table 1 for the specific formula
[0031] Table 1
[0032]
Embodiment 2 and 5
[0033] The comparative test that adopts embodiment of the present invention 2 and 5 to carry out in conjunction with other several medicines below
[0034] Step 1: Experimental animals and grouping
[0035] This experiment is divided into in vivo experiment and in vitro experiment. The in vitro experiment uses 40 clean grade healthy New Zealand white rabbits (half male and half female), weighing 2.3~3kg. For the in vivo experiment, 40 8-week-old healthy male rats, weighing 180-220 g, were randomly divided into five groups: normal saline group (in vitro experiment) or ordinary gauze group (in vivo experiment), Yunnan Baiyao powder group, and compound drug group / Compound ointment group (1.5g / L PHA+40g / Lchitosan), phytohemagglutinin group (1.5g / L), chitosan group (40g / L), 8 rats in each group.
[0036] Step 2: Observe Indicators
[0037] In vitro test indicators are ① whole blood coagulation time (CT); ② prothrombin time (PT); ③ platelet aggregation test (PA). In vivo experi...
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