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Composite medicine and ointment for hemostasis and preparation methods of composite medicine and ointment

A technology for compounding medicaments and ointments, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, blood diseases, etc., can solve problems such as fast, safe, effective, rare, unable to achieve hemostatic effect, adverse consequences, etc., and achieve good hemostasis effect. , The effect of promoting automatic blood coagulation and preventing infection

Inactive Publication Date: 2012-11-14
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although hemostatic drugs are widely used, fast, safe and effective ones are rare. There are currently three types of hemostatic drugs on the market: the first type is procoagulant drugs, such as vitamin K, which are only suitable for vitamin K deficiency bleeding The second category is anti-fibrinolytic drugs, such as aminomethylbenzoic acid, which are only suitable for hyperfibrinolytic bleeding; the third category is vasoconstrictor drugs, such as pituitary hormone, which are only suitable for blood vessel rupture Sexual bleeding; all three hemostatic drugs have contraindications and relatively large side effects. If the hemostatic drug cannot be selected correctly, it will not only be ineffective, but may also lead to serious adverse consequences
Traditional hemostasis methods will cause remote tissue ischemia and metabolic abnormalities, leading to serious complications, and cannot achieve good hemostatic effect, which is a major factor causing high mortality
In addition, when using a tourniquet, it is difficult to stop bleeding when the pressure is insufficient, and when the pressure is too high, it will cause necrosis of the part below the hemostasis due to ischemia, and it is difficult to save oneself when an individual soldier is injured.

Method used

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  • Composite medicine and ointment for hemostasis and preparation methods of composite medicine and ointment
  • Composite medicine and ointment for hemostasis and preparation methods of composite medicine and ointment
  • Composite medicine and ointment for hemostasis and preparation methods of composite medicine and ointment

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Experimental program
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Effect test

preparation example Construction

[0024] A preparation method of compound medicament for hemostasis:

[0025] (1) Weigh 0.01-0.02g phytohemagglutinin, 0.2-0.5g chitosan, and mix well;

[0026] (2) Add the above mixture into 10-30ml of distilled water and stir evenly to prepare a compound medicine.

[0027] A preparation method of composite ointment for hemostasis:

[0028] (1) Weigh 0.01-0.02g phytohemagglutinin, 0.2-0.5g chitosan, and mix well;

[0029] (2) Weigh 1.5-3g sodium carboxymethyl cellulose as a film-forming material, melt it into a colloidal liquid in 10-30ml of distilled water, add the mixture in step (1) to the colloidal liquid in step (2) and stir evenly to prepare Get compound ointment.

[0030] See Table 1 for the specific formula

[0031] Table 1

[0032]

Embodiment 2 and 5

[0033] The comparative test that adopts embodiment of the present invention 2 and 5 to carry out in conjunction with other several medicines below

[0034] Step 1: Experimental animals and grouping

[0035] This experiment is divided into in vivo experiment and in vitro experiment. The in vitro experiment uses 40 clean grade healthy New Zealand white rabbits (half male and half female), weighing 2.3~3kg. For the in vivo experiment, 40 8-week-old healthy male rats, weighing 180-220 g, were randomly divided into five groups: normal saline group (in vitro experiment) or ordinary gauze group (in vivo experiment), Yunnan Baiyao powder group, and compound drug group / Compound ointment group (1.5g / L PHA+40g / Lchitosan), phytohemagglutinin group (1.5g / L), chitosan group (40g / L), 8 rats in each group.

[0036] Step 2: Observe Indicators

[0037] In vitro test indicators are ① whole blood coagulation time (CT); ② prothrombin time (PT); ③ platelet aggregation test (PA). In vivo experi...

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Abstract

The invention discloses composite medicine and ointment for hemostasis and preparation methods of the composite medicine and ointment. The composite medicine is prepared by adding a proper amount of distilled water into phytohemagglutinin and chitosan according to certain proportion; and the composite ointment is in a paste type and prepared by by adding a proper amount of distilled water into phytohemagglutinin, chitosan and sodium carboxymethylcellulose according to certain proportion. The composite medicine and ointment can be stored in a refrigerator at 4 DEG C for a long time for use anytime. The composite medicine and ointment disclosed by the invention realize fast hemostasis and good effects, prevent side effects, are convenient to carry, can be conveniently prepared into various types of products such as hemostasis spray and hemostasis bandage, and can be applied to battlefields to reduce mass casualties caused by excessive bleeding as well as to fast hemostasis in the occasions of disaster rescue, accidental injuries, various hemorrhagic diseases, mild and moderate traumatic hemorrhage and the like.

Description

technical field [0001] The invention relates to a compound medicine, an ointment and a preparation method thereof which can quickly stop bleeding and promote wound healing. Background technique [0002] Uncontrollable traumatic hemorrhage is often the main cause of death in battlefields, natural disasters, and various daily emergencies. The wounded who died early due to hemorrhage in the war accounted for 49% of the dead and wounded, and it was the first cause of death of the wounded. Hemorrhage is the second cause of casualty death in peacetime, accounting for about 39%. There are more than 9 million patients who use hemostatic drugs in my country every year, including patients undergoing surgery, patients with trauma, and patients with bleeding disorders. Traumatic bleeding is mostly external bleeding, and it is one of the most common critical illnesses, characterized by rapid bleeding and large amount of bleeding. Mild trauma can cause damage to the skin or superficial...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/16A61K31/722A61P7/04
Inventor 铁茹于军张海锋杨发邱继欢罗文俊姚俊李晓璇
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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