Method for synthesizing pyroglutamic calcium glutamate with shells serving as calcium sources

A technology of calcium pyroglutamate and a synthesis method, which is applied in the field of calcium pyroglutamate synthesis to achieve the effects of good product quality and simple process

Inactive Publication Date: 2012-11-14
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

my country is rich in aquatic product resources, but a large amount of waste (oyster shel...

Method used

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Examples

Experimental program
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Effect test

example 1

[0012] Example 1: Soak 130 grams of oyster shells in 0.05M hydrochloric acid solution for 1 hour, then scrub to remove the silt and other adsorbents on the surface of the shells, dry them at 80°C, crush them through a 60-mesh sieve, and then process them with tap water to obtain the synthesis Calcium glutamic acid chelated calcium source shell powder 110 grams. Mix 110 grams of calcium source shell powder with 258.2 grams of pyroglutamic acid and 2.5 liters of distilled water, stir and heat to 60 ° C, keep warm for chelation for 2.0 hours, cool, and filter with suction; concentrate the filtrate to 250 ml under reduced pressure, add 95% Edible alcohol until the ethanol saturation reaches 90%, stir, and let stand overnight. Suction filtration, and the resulting crystals are dried in an oven at 90°C to obtain calcium pyroglutamate (C 10 h 12 N 2 CaO 6 ) product 288 grams.

example 2

[0013] Example 2: The steps and methods are the same as those in Example 1. The raw material is selected from scallop shells or clam shells, and the quality of the calcium pyroglutamate product prepared by it is the same as that of oyster shell raw materials.

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Abstract

The invention relates to a method for synthesizing pyroglutamic calcium glutamate with shells serving as calcium sources. Processing steps comprise shell pretreatment, synthesis, crystallization and drying. The method includes immersing the shells with 0.05M hydrochloric acid, drying, smashing and processing the shells with elutriation to obtain calcium shell powder, compounding pyroglutamic acid with the shell powder (the calciumcontent of calcium carbonate is calculated by 95%) according to a molar ratio of 2: (1.0-1.2), adding distilled water 20 to 25 times of the weight of the shell powder, stirring and heating the mixture to 55 DEG C to 60 DEG C, keeping the temperature for 1.5 to 2.0 hours, and performing cooling and suction filtration; performing pressure reduction and concentration on the obtained filtrate to enable the volume to be1/10, adding 95% of edible alcohol until the ethanol saturation degree is 90%, performing stirring, standing and filtering; and performing suction filtration, and drying the obtain crystals in a drying oven of 90 DEG C to obtain the pyroglutamic calcium glutamate product. According to the method, the process is simple, the product water solubility is good, various shells can be utilized highly, and the product can serve as calcium supplement, dietary supplement for improving the brain health level and the like.

Description

Technical field: [0001] The invention relates to a kind of scorched grain using shellfish processing wastes (oyster shells, scallop shells, etc.) Calcium Amino Acid Synthesis Method. Background technique: [0002] L-pyroglutamic acid (2-pyrrolidone-5-carboxylic acid, PCA; pyoglutamic acid; 5-Oxoproline), the molecular formula is C 5 h 7 NO 3 , is the intramolecular dehydration product of L-glutamic acid. In vivo, L-PCA exists in a variety of tissues and body fluids (including brain and cerebrospinal fluid) in free form, and participates in the amino terminus of many neuropeptides such as thyrotropin-releasing hormone, gonadotropin-releasing hormone and neurotensin. Scholars at home and abroad have found that L-PCA can not only be absorbed by the gastrointestinal mucosa in large quantities, but also quickly enter the brain through the blood-brain barrier, increase cerebral blood flow, and promote the uptake and utilization of glucose by brain tissue, so it has the functio...

Claims

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Application Information

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IPC IPC(8): C07D207/28
Inventor 魏玉西齐宏涛徐传金于佳柳翠青
Owner QINGDAO UNIV
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