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Preparation method of monodisperse large-particle size crosslinked polymethyl methacrylate (PMMA) microspheres

A large particle size, monodisperse technology, applied in the preparation of monodisperse large particle size cross-linked PMMA microspheres, can solve the problems of small particle size and no cross-linking degree of microspheres, and achieve large particle size and cross-linking degree. Adjustable, easily available effects

Inactive Publication Date: 2012-11-21
NORTHWESTERN POLYTECHNICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, they obtained microspheres with small particle size and no degree of cross-linking

Method used

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  • Preparation method of monodisperse large-particle size crosslinked polymethyl methacrylate (PMMA) microspheres
  • Preparation method of monodisperse large-particle size crosslinked polymethyl methacrylate (PMMA) microspheres

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Weigh 1.0 g of PMMA seed balls with a particle size of 8.3 μm and 45 mL of 0.2% SDS solution in a beaker until fully dispersed, and add them to a four-neck flask equipped with mechanical stirring, condenser, nitrogen gas inlet and outlet, and heating jacket; in another Weigh 1.5g of cyclohexane and 90mL of 0.2% SDS solution into the beaker and ultrasonicate until a stable emulsion is formed, then add it to the above-mentioned four-neck flask; gradually raise the temperature to 35°C, and swell for 18h to activate the PMMA seed balls; weigh 0.1 g AIBN, 2.0g MMA and 2.0g EGDMA, after shaking and dissolving, add 90mL of 0.2% SDS solution and sonicate until a stable emulsion is formed, add it to the above-mentioned four-necked bottle, and carry out monomer swelling for 25h; add 3% PVP aqueous solution to the above-mentioned four-necked bottle In the mouth bottle, insert the nitrogen inlet under the liquid phase, replace the air for 30 minutes, then lift the nitrogen inlet int...

Embodiment 2

[0032] Weigh 1.0 g of PMMA seed balls with a particle size of 12.2 μm and 45 mL of 0.3% SDS solution in a beaker until fully dispersed by ultrasonication, and add them to a four-necked flask equipped with mechanical stirring, condenser, nitrogen gas inlet and outlet, and heating jacket; Weigh 1.5g of EM-221 and 90mL of 0.3% SDS solution into a beaker and ultrasonicate until a stable emulsion is formed, then add it to the above-mentioned four-neck flask; gradually raise the temperature to 35°C, and swell for 18 hours to activate the PMMA bulbs; weigh into the beaker 0.1g AIBN, 2g MMA and 1.5g EGDMA, after shaking and dissolving, add 90mL of 0.3% SDS solution and sonicate to form a stable emulsion, add it to the above four-neck bottle, and carry out monomer swelling for 25h; add 3% PVP aqueous solution to the above four-necked bottle In the mouth bottle, insert the nitrogen inlet under the liquid phase, replace the air for 30 minutes, then lift the nitrogen inlet into the gas pha...

Embodiment 3

[0035] Weigh 1.0 g of PMMA seed balls with a particle size of 18.5 μm and 45 mL of 0.2% SDS solution in a beaker until fully dispersed, and add them to a four-necked flask equipped with mechanical stirring, condenser, nitrogen inlet and outlet, and a heating jacket; Weigh 1.5g of toluene and 90mL of 0.2% SDS solution into a beaker and ultrasonicate until a stable emulsion is formed, then add it to the above-mentioned four-neck flask; gradually raise the temperature to 35°C, and swell for 18 hours to activate the PMMA seed balls; weigh 0.1g of AIBN into the beaker , 2.0g MMA and 1.5g EGDMA, after shaking and dissolving, add 90mL of 0.2% SDS solution to ultrasonic to form a stable emulsion, add it to the above four-necked bottle, and carry out monomer swelling for 25h; add 3% PVP aqueous solution to the above-mentioned four-necked bottle In the process, insert the nitrogen inlet into the liquid phase, replace the air for 30 minutes, then lift the nitrogen inlet to the gas phase a...

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Abstract

The invention relates to a preparation method of monodisperse large-particle size crosslinked polymethyl methacrylate (PMMA) microspheres. The method comprises the steps of preparing PMMA seed spheres through dispersion polymerization, swelling the PMMA seed spheres by using an appropriate swelling agent, then carrying out a second swelling though choosing an appropriate swelling agent to obtain a required particle size, adding dispersing agent solution, and heating for polymerization to obtain the monodisperse large-particle size crosslinked PMMA microspheres. The monodisperse large-particle size crosslinked PMMA microspheres prepared by the method provided by the invention can meet the demands for the PMMA microspheres with different particle sizes in the fields of chromatographic separation, biomedicine, and photoelectron and the like.

Description

technical field [0001] The invention relates to a preparation method of monodisperse large-diameter cross-linked PMMA microspheres. Background technique [0002] Monodisperse, large particle size cross-linked functional polymer microspheres have large specific surface area, strong adsorption, strong coagulation and strong mechanical strength, making them widely used in chromatographic separation, biochemistry, standard metering and other high-tech fields. have a wide range of uses. [0003] In view of the wide use of monodisperse PMMA (polymethyl methacrylate) microspheres, researchers at home and abroad have conducted many studies to explore the preparation methods of monodisperse PMMA microspheres and the influencing factors of particle size and monodispersity. Tong Bin et al. (Preparation of monodisperse cross-linked PMMA microspheres by dispersion polymerization, Journal of Beijing Institute of Technology, 2007, 27 (3): 270-273.) prepared single component PMMA with a pa...

Claims

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Application Information

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IPC IPC(8): C08F265/06
Inventor 张秋禹许海龙马明亮张和鹏刘瑜张宝亮雷兴峰
Owner NORTHWESTERN POLYTECHNICAL UNIV
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