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Near-field Raman biosensor based on echo wall mode

A biosensor and whispering gallery mode technology, applied in the field of biological and chemical analysis and sensing, can solve the problems of low signal-to-noise ratio, sample damage, low optical coupling efficiency, etc., to improve signal strength and signal-to-noise ratio, improve Enhancement factor, the effect of improving the signal-to-noise ratio

Inactive Publication Date: 2012-11-28
CHANGCHUN INST OF OPTICS FINE MECHANICS & PHYSICS CHINESE ACAD OF SCI
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  • Application Information

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Problems solved by technology

However, the current whispering gallery mode biosensing method generally adopts the far-field excitation method. Due to the large difference between the refractive index of air and the measured object, the coupling efficiency of light is low, and a higher power laser is required to excite the sample. , which will cause damage to the sample; not only that, this excitation method often inevitably introduces other scattering and substrate interference, and the signal-to-noise ratio is low

Method used

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  • Near-field Raman biosensor based on echo wall mode
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Embodiment 1

[0029] Such as figure 1As shown, the near-field Raman biosensor based on the whispering gallery mode of the present invention includes a tunable laser, an excitation tapered optical fiber 1-1, a microsphere resonant cavity 1-2, an output tapered optical fiber 1-3, and a metal nanoparticle 1 -4; one end of the excitation tapered fiber 1-1 is aligned with the output window of the tunable laser, and the microsphere resonator 1-2 is located at the taper region of the excitation tapered fiber 1-1 and the output tapered fiber 1-3, The metal nanoparticles 1-4 are adsorbed on the surface of the microsphere resonant cavity 2-2, and the measured biological sample 1-5 is adsorbed on the metal nanoparticles 1-4.

[0030] The excitation tapered optical fiber 1-1 and output tapered optical fiber 1-3 can be single-mode, multi-mode optical fiber or tapered optical waveguide. The microsphere resonator is a quartz microsphere or a high-Q plane microcavity. The metal nanoparticles 1-4 are gold...

Embodiment 2

[0033] Such as figure 2 As shown, the near-field Raman biosensor based on the whispering gallery mode of the present invention includes a tunable laser, a coupling tapered fiber 2-1, a microsphere resonant cavity 2-2, a metal nanoparticle 2-3; a coupling tapered fiber 2 One end of -1 is aligned with the output window of the tunable laser, the microsphere resonator 2-2 is located at the tapered region of the coupling tapered optical fiber 2-1, and the metal nanoparticles 2-3 are adsorbed on the microsphere resonator 2-2 On the surface, the measured biological sample 2-4 is adsorbed on the metal nanoparticles 2-3.

[0034] The light emitted by the tunable laser enters the coupling tapered fiber 2-1. When the light passes through the tapered region, it is coupled with the near-field of the microsphere resonator 1-2 through the evanescent field, and the light is coupled into the microsphere resonator 2-2. At a series of specific wavelengths (low-order and high-order resonance wa...

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Abstract

The invention relates to a near-field Raman biosensor based on an echo wall mode. The biosensor adopts two technical schemes comprising 1, aiming one end of an exciting conical fiber to aim at the output window of a tunable laser, arranging a microballoon resonant cavity at the exciting conical fiber and the cone-shape zone of the output conical fiber, and absorbing a biological sample to be examined on the surface of the cone-shape zone of the output conical fiber; and 2, aiming one end of a coupling conical fiber to aim at the output window of the tunable laser, arranging the microballoon resonant cavity at the cone-shape zone of the coupling conical fiber, and absorbing the biological sample to be examined on the surface of the microballoon resonant cavity. According to the invention, the near-field Raman biosensor based on the echo wall mode has the characteristics of large signal intensity and high signal to noise ratio, the high energy density near-field excitation and efficient detection can be realized, and the change information of the high sensitivity refractive index of the detected molecules can be acquired while the surface Raman enhancement effect is acquired.

Description

technical field [0001] The invention belongs to the fields of biology and chemical analysis and sensing, and relates to a near-field Raman biosensor based on a whispering gallery mode. Background technique [0002] What Raman scattering detects is the frequency shift that occurs after inelastic scattering of light and matter, and the Raman shift is closely related to the vibrational mode of molecules. The characteristic vibration modes reflect the characteristics of the molecular structure. In the non-degenerate state, the vibration frequencies of different modes are also different. The number of vibration modes of molecules increases with the increase of molecular structure complexity, but since chemical bonds mainly affect molecular vibrations, the characteristic vibration modes and frequencies of a specific functional group are relatively fixed, so Raman scattering has a good Chemical specificity, very suitable for the research needs of chemical and biological systems. ...

Claims

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Application Information

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IPC IPC(8): G01N21/65
Inventor 吴一辉郝鹏李锋王全龙
Owner CHANGCHUN INST OF OPTICS FINE MECHANICS & PHYSICS CHINESE ACAD OF SCI
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