Recombinant fusion protein PTD-HSP27 and use thereof

A technology of fusion protein and gene, applied in the field of genetic engineering, to achieve the effect of inhibiting apoptosis, improving the route of medication, and expanding the scope of application
CN102827291AInactive Publication Date: 2012-12-19钟敬祥
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
钟敬祥
Publication Date
2012-12-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses recombinant fusion protein PTP-HSP27 and use thereof; an amino acid sequence is SEQ ID NO.1; the recombinant fusion protein PTP-HSP27 disclosed by the invention not only has the biological activity of HSP27, but also has a transcellular barrier transportation function; the recombinant fusion protein PTP-HSP27 can effectively perforate into lenticular epithelial cells (LEC); the apoptosis of the lenticular epithelial cells is alleviated; and the development and progression of cataract is delayed greatly. According to the invention, the recombinant fusion protein PTP-HSP27 endows the transcellular barrier transportation function of PTD to the HSP27, thus, the HSP27 easily perforates the cell barrier of corneas and effectively enters eyes through cornea tissues; and the application range of the recombinant fusion protein PTD-HSP27 in an eye part is expanded.
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Description

technical field

[0001] The present invention relates to the field of genetic engineering, specifically to the field of design and recombinant fusion protein technology, in particular to a recombinant fusion protein PTD-HSP27 and its application. Background technique

[0002] Cataract, a disease that occurs on the lens inside the eye, is the most common cause of blindness and visual impairment. Analyzing and exploring the development process and pathogenesis of cataract, and developing effective drugs for the prevention and treatment of cataract have important social benefits. Studies have confirmed that apoptosis is earlier than cataract in space and time, and it is deduced that lens epithelial cell apoptosis may be the common cellular basis of various cataracts. The mechanism of cell apoptosis believes that if the epithelial cells undergo apoptosis, the growth of the lens will stagnate, and the lens epithelial cells (LEC) will fall off, which will lead to a series of chang...

Claims

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