Application of ginkgolic acid in skin whitening, freckle removing and resurfacing

A ginkgolic acid, whitening and freckle-removing technology, which is applied in the field of therapeutic cosmetics and biomedicine, can solve problems such as human health damage, achieve the effects of promoting proliferation, inhibiting melanin production, and using it without side effects

Inactive Publication Date: 2013-01-02
王青
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, heavy metals such as lead and mercury in some whitening and freckle products on the market exceed the standard, which has caused serious damage to human health; therefore, the market needs to develop whitening and freckle-removing cosmetic products that come from natural sources, have significant effects, and have no adverse reactions. The pursuit of beauty and treatment needs; the development of such products has a good market prospect and is very beneficial and necessary
There is no report on the use of ginkgolic acid in whitening, freckle removal and skin resurfacing

Method used

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  • Application of ginkgolic acid in skin whitening, freckle removing and resurfacing
  • Application of ginkgolic acid in skin whitening, freckle removing and resurfacing
  • Application of ginkgolic acid in skin whitening, freckle removing and resurfacing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The extraction process of ginkgolic acid from the ginkgo biloba exocarp is as follows: the ginkgo biloba exocarp is peeled off, dried, and crushed with a grinder. Accurately weigh a certain amount of crushed Ginkgo biloba exocarp, add 80% ethanol with a material-to-liquid ratio of 1:6 (W / V), stir and extract twice at a water bath temperature of 60°C, each extraction time is 4 hours , (Note: After adding liquid, seal the mouth of the beaker with plastic wrap to prevent the evaporation of ethanol). After the leaching is finished, use a suction filter to collect the filtrate. Concentrate the filtrate with a vacuum rotary evaporator under the conditions of a temperature of 55°C, a pressure of 0.008-0.009 MPa, and concentration under reduced pressure. It was dried in vacuum at 60°C to obtain the ginkgolic acid extract. The properties were: light brown extract, slightly odor, soluble in alcohol, insoluble in water; weighed and determined the ginkgolic acid content (mg / g).

[0...

Embodiment 2

[0025] The extraction process of ginkgo phenolic acid in ginkgo fruit is as follows: peel the ginkgo fruit and put it into a tissue crusher to crush. Accurately weigh a certain amount of crushed ginkgo, add 80% ethanol with a material-to-liquid ratio of 1:10 (W / V), stir and extract twice at a water bath temperature of 60°C, each extraction time is 4 hours, (Note : After adding liquid, seal the mouth of the beaker with plastic wrap to prevent the evaporation of ethanol). After the extraction, centrifuge (5000 rpm, 15 minutes), and take the supernatant. Concentrate the supernatant with a vacuum rotary evaporator at a temperature of 55°C, a pressure of 0.008-0.009MPa, concentrate under reduced pressure, and vacuum-dry at 60°C to obtain ginkgolic acid extract. The properties are: light brown extract, slightly smelly , Soluble in alcohol, insoluble in water. Weigh and determine the content of ginkgolic acid (mg / g).

[0026] Ginkgo phenolic acid content determination: the same as in...

Embodiment 3

[0030] The extraction process of ginkgo phenolic acid in ginkgo biloba leaves is as follows: the ginkgo biloba leaves are cut into small pieces and placed in a crusher to crush them. Accurately weigh a certain amount of crushed ginkgo leaves, add 80% ethanol with a material-to-liquid ratio of 1:6 (W / V), stir and extract twice at a water bath temperature of 60°C, each extraction time is 4 hours, ( Note: After adding liquid, seal the mouth of the beaker with plastic wrap to prevent the evaporation of ethanol). After the extraction, centrifuge (5000 rpm, 15 minutes), and take the supernatant. Concentrate the supernatant with a vacuum rotary evaporator at a temperature of 55°C, a pressure of 0.008-0.009MPa, concentrate under reduced pressure, and vacuum-dry at 60°C to obtain ginkgolic acid extract. The properties are: light brown extract, slightly smelly , Soluble in alcohol, insoluble in water. Weigh and determine the content of ginkgolic acid (mg / g).

[0031] Ginkgo phenolic aci...

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Abstract

The invention relates to application of ginkgolic acid in skin whitening, freckle removing and resurfacing. The ginkgolic acid comprises ginkgolic acid, ginkgol and bilobol and can be obtained from the extracts of such parts of the gingko as leaves, fruits, testae and rootstalks by a chemical separation method. A medicament or cosmetic which contains ginkgolic acid and is used for skin whitening, freckle removing and resurfacing contains 0.001-80% by weight of ginkgolic acid and pharmaceutically common external preparation substrates or acceptable carriers, wherein the preparation is any one pharmaceutically called external dosage form. Pharmacological experiment studies show that the preparation has the effect of inhibiting the activity of tyrosinase and melanogenesis in the skin, can obviously promote proliferation of keratinocytes and apoptosis and has obvious skin whitening, freckle removing and resurfacing effects. Clinical trials show that the preparation has obvious effects of improving the preventing dark yellow complexion and facial pigmentation, is one hundred percent in effective rate, is safe to use and does not have side effects.

Description

Technical field [0001] The invention belongs to the field of therapeutic makeup and biomedicine, and specifically relates to the use of ginkgolic acid in whitening, removing spots and peeling skin. Background technique [0002] In recent years, with the aging of the population, environmental pollution, and rising global temperature, more and more people have developed skin pigment disorders. Finding safer and more effective new topical skin whitening and freckle removal agents is one of the current research hotspots in cosmeceuticals. Whitening and removing freckles have always been a topic of eager attention to people. People hope to get fair and smooth skin through the use of whitening care products, and use functional whitening cosmetics to reduce pigmentation such as age spots and melasma. With the development of biochemical technology, people's understanding of the biological mechanism of melanin synthesis is deepening, and more and more scientific researchers tend to find ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K8/368A61K8/33A61K36/16A61K31/192A61K31/05A61Q19/02A61P17/00
Inventor 雷红王青
Owner 王青
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