Formulation and preparation method of antibacterial spray

A spray, chitosan technology, applied in the direction of antifungal agents, medical preparations containing active ingredients, antibacterial drugs, etc., can solve problems such as unsatisfactory sterilization effect

Inactive Publication Date: 2013-01-02
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although chitosan has a certain bactericid

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0016] Example 1:

[0017] Take 0.6g of carboxymethyl chitosan to 1L in a beaker, add 300mL of water to swell, and let it stand. If it does not dissolve, add dilute acetic acid dropwise, stir until it dissolves while adding dropwise, and leave it for 1 hour. Take another 5g of polyhexamethylene guanidine and add water to dissolve it. Add the polyhexamethylene guanidine solution to the chitosan solution and mix well, then add glycerin and vitamin E to mix, and then add water to make up the volume. After stirring, fill and irradiate to sterilize.

Example Embodiment

[0018] Example 2:

[0019] Take 0.3 g of carboxymethyl chitosan to a 1L beaker, add 300 mL of water to swell, and let it stand. If it does not dissolve, add dilute acetic acid dropwise, stir until it dissolves while adding dropwise, and leave it for 1 hour. Take another 8g of polyhexamethylene guanidine and dissolve in water. Add the polyhexamethylene guanidine solution to the chitosan solution and mix well, then add glycerin and vitamin E to mix, and then add water to make up the volume. After stirring, fill and irradiate to sterilize.

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PUM

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Abstract

The invention discloses a formulation and a preparation method of an antibacterial spray with antibacterial, hemostasis and promotion of wound healing effects. The spray contains water which is used as a solvent, and chitosan, glycerol, polyhexamethylene guanidine and vitamin E which are used as main effective components. The antibacterial spray has obvious activity inhibition on growth of multiple types of pathogenic bacteria, the killing rate of the antibacterial spray on staphylococcus aureus, escherichia coli and candida albicans can reach 99%, and the antibacterial spray does not stimulate skins and mucosa, is suitable for treating skin and mucosa wound surface infection, and can be used for promoting the wound healing.

Description

technical field [0001] The invention relates to a formulation and preparation method of an antibacterial spray with antibacterial, hemostatic and capable of promoting wound healing. The spray uses water as a solvent and mainly uses chitosan, glycerin, polyhexamethylene guanidine, and vitamin E. Active ingredients. The invention has obvious inhibitory activity on the growth of various pathogenic bacteria, and the killing rate on Staphylococcus aureus, Escherichia coli and Candida albicans can reach 99%. It is non-irritating to the skin and mucous membrane, and is suitable for the treatment of wound infection of the skin and mucous membrane, and can promote wound healing. technical background [0002] Trauma is one of the most common diseases in daily life, mainly including skin and mucous membrane wound injuries. The methods for treating wounds on the market mainly include powdered medicines, band-aids, ointment medicines and liquid auxiliary materials. The irritation of t...

Claims

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Application Information

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IPC IPC(8): A61K31/785A61K31/722A61K31/737A61P31/04A61P31/10A61P17/02A61P7/04
CPCY02A50/30
Inventor 郭文娟范敏付文娟
Owner TIANJIN POLYTECHNIC UNIV
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