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Compound povidone iodine suppository and preparation method and application thereof

A technology of povidone-iodine suppositories and povidone-iodine, applied in suppository delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., to achieve the effects of fewer administration times, convenient medication, and good curative effect

Active Publication Date: 2015-02-25
广东省天宝生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to overcome the deficiency of only using povidone-iodine single drug composition in the past, provide a kind of by povidone-iodine, rhubarb powder and eucalyptus oil according to the pathogenic bacteria of sow endometritis and pathological change compound povidone iodine suppository

Method used

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  • Compound povidone iodine suppository and preparation method and application thereof
  • Compound povidone iodine suppository and preparation method and application thereof
  • Compound povidone iodine suppository and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The formula components of the compound povidone-iodine suppository are as follows: 50 g of povidone-iodine, 50 g of rhubarb powder, 100 g of eucalyptus oil, 400 g of macrogol 1000 and 400 g of macrogol 4000.

[0039] The preparation method is as follows:

[0040] (1) Weigh 50g of povidone-iodine raw powder and 50g of rhubarb powder after passing through an 80-mesh sieve, and set aside;

[0041] (2) Weigh 400g of polyethylene glycol 1000 and 400g of polyethylene glycol 4000, add to the batching container and heat to melt to form a matrix;

[0042](3) Add povidone-iodine raw powder and rhubarb powder weighed in step (1) to the melted matrix in step (2), and stir evenly;

[0043] (4) Add 100g of eucalyptus oil to the mixture stirred in step (3), and continue to stir evenly;

[0044] (5) Stir step (4) evenly and pour it into the plug mold while it is hot;

[0045] (6) Place the plug mold in step (5) in a freezer at a temperature of 0~4°C to cool;

[0046] (7) Take it ou...

Embodiment 2

[0048] The formula components of the compound povidone-iodine suppository are as follows: 35 g of povidone-iodine, 35 g of rhubarb powder, 130 g of eucalyptus oil, 400 g of macrogol 1000 and 400 g of macrogol 4000.

[0049] The preparation method is as follows:

[0050] (1) Weigh 35g of povidone-iodine original powder and 35g of rhubarb powder after passing through an 80-mesh sieve, and set aside;

[0051] (2) Weigh 400g of polyethylene glycol 1000 and 400g of polyethylene glycol 4000, add to the batching container and heat to melt to form a matrix;

[0052] (3) Add povidone-iodine raw powder and rhubarb powder weighed in step (1) to the melted matrix in step (2), and stir evenly;

[0053] (4) Add 130g of eucalyptus oil to the mixture stirred in step (3), and continue to stir evenly;

[0054] (5) Stir step (4) evenly and pour it into the plug mold while it is hot;

[0055] (6) Place the plug mold in step (5) in a freezer at a temperature of 0~4°C to cool;

[0056] (7) Tak...

Embodiment 3

[0057] Example 3 Antibacterial test in vitro to the main pathogenic bacteria of sow endometritis

[0058] In this example, the experiment was carried out with the compound preparation prepared from the formulation components of the above-mentioned Example 1 and Example 2. After the isolation, culture and identification of clinical sow endometritis pathogenic bacteria, the in vitro inhibitory effect on the main pathogenic bacteria was evaluated.

[0059] Select cases of suspected sow endometritis in multiple pig farms in Guangdong Province, and collect disease materials after diagnosis. The operation is as follows: before sampling, wash with warm water, disinfect with 75% alcohol cotton balls, use sterilized vas deferens to aseptically collect uterine secretions for isolation and identification of main pathogenic bacteria: smear microscopy, anaerobic enrichment culture, Aerobic enrichment culture and bacterial identification. According to the identification results, the mai...

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Abstract

The invention discloses a compound povidone iodine suppository and a preparation method and an application thereof. The compound povidone iodine suppository comprises the following components by weight: 3-7 parts of povidone iodine, 3-7 parts of rheum officinale powder, 5-15 parts of eucalyptus oil, 30-50 parts of polyethylene glycol 1000, and 30-50 parts of polyethylene glycol 4000. The preparation method of the compound suppository is a hot melting molding method, which comprises the following steps: melting polyethylene glycol 1000 and polyethylene glycol 4000 to form a matrix; orderly and uniformly dispersing povidone iodine, rheum officinale powder, and eucalyptus oil in the matrix, finally pouring the mixture into a metal mold, cooling and demolding. The compound povidone iodine suppository widens the application dosage form of povidone iodine in clinical veterinary medicine, has good treatment effect on sow endometritis, can reach the purposes of safety, high efficiency, stability, convenient administration, low administration frequency, no environment pollution, and the like, and has important significance on clinical medication and veterinary drug development.

Description

technical field [0001] The invention belongs to the technical field of veterinary therapeutic drugs, in particular to a compound povidone-iodine suppository and its preparation method and application. Background technique [0002] Sow endometritis is a common reproductive organ disease in sows, and it is one of the main causes of reproductive disorders in sows. It usually occurs after childbirth, during dystocia, uterine prolapse, retained placenta, or infection with pathogenic bacteria after mating. The pathogenic bacteria that cause endometritis in sows are mainly Escherichia coli, streptococcus, staphylococcus, and Pseudomonas aeruginosa. The clinical symptoms are mainly manifested as elevated body temperature, decreased appetite, reduced lactation or no lactation, no estrus, delayed estrus, repeated infertility, vaginal discharge with purulent secretions, etc., embryonic death, abortion or even death in sows. disuse. [0003] In recent years, the drugs commonly used c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/02A61K36/708A61P15/00A61P31/04A61K31/79
Inventor 孙永学曾东平曾振灵刘雅红黄显会
Owner 广东省天宝生物制药有限公司
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