Optical resolution type photoacoustic microscope based on optical beam scanning

A photoacoustic microscope and beam scanning technology, applied in the field of optical resolution photoacoustic microscope, can solve the problems of difficult miniaturization and portable design, large laser volume, difficult maintenance, etc., and achieve simple signal post-processing circuit, large imaging depth, easy maintenance effect

Inactive Publication Date: 2013-01-02
曾吕明
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  • Abstract
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Problems solved by technology

The above reports all use laser galvanometers to realize beam scanning instead of mechanical scanning to achieve fast imaging, but they all use relatively high-power solid-state lasers as photoacoustic excitation sources, and such lasers usual...

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  • Optical resolution type photoacoustic microscope based on optical beam scanning

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Embodiment 1

[0022] Embodiment 1 The structure of this embodiment is as follows figure 1 As shown, the names of the components are: 1. Laser diode, 2. Collimating lens, 3. Multi-dimensional laser galvanometer, 4. Focusing lens, 5. Right-angle prism, 6. Coupling liquid box, 7. Ultrasonic coupling liquid, 8. .Film, 9. Shell, 10. Lifting platform, 11. Ultrasonic sensor, 12. Signal preprocessing circuit, 13. Data acquisition circuit, 14. Computer, 15. Vibrating mirror driving circuit, 16. Clock circuit, 17. Driving power supply circuit.

[0023] Among them, the laser diode 1 is a pulsed semiconductor laser diode (PFAS1S12, PerkinElmer), the working wavelength is 850nm, and the single pulse energy is about 3.9uJ; the ultrasonic sensor 11 is a 256-element surface array probe with a hollow structure (5M16*16-1.0*1.0 , Guangzhou Doppler Electronic Technology Co., Ltd.), the center frequency is 5.0MHz, the effective aperture is 16mm, and the shell model is B16; the focusing lens 4 adopts an aspher...

Embodiment 2

[0037] Embodiment 2 An optical resolution photoacoustic microscope based on beam scanning, which is similar in structure to Embodiment 1, the difference is that the ultrasonic sensor 11 adopts a hollow unit angle probe (5.0 P9×9K1), the center frequency is 5.0MHz, the size is 9 mm×9 mm, and the external interface adopts Q9 (BNC) interface.

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Abstract

The invention provides an optical resolution type photoacoustic microscope based on optical beam scanning. The photoacoustic microscope comprises a laser diode, a collimating lens, a multidimensional laser galvanometer, a focusing lens, a rectangular prism, a coupling liquid box, an ultrasonic coupling liquid, a film, a shell, a lifting platform, an ultrasonic sensor, a signal processing circuit, a data acquisition circuit, a computer, a galvanometer driving circuit, a clock circuit and a driving power circuit. According to the invention, miniature, inexpensive and easily maintained laser diode is applied to the field of optical resolution forward photoacoustic microscopy excitation, and the laser galvanometer is used to realize substitution of mechanical scanning by beam scanning to achieve fast imaging. The photoacoustic microscope has the advantages of portable volume, high resolution and fast imaging, and can be widely applied to photoacoustic microimaging in the fields of material detection, industrial inspection and medical image.

Description

technical field [0001] The invention relates to a photoacoustic microscopic imaging technology, in particular to an optical resolution photoacoustic microscope based on beam scanning. Background technique [0002] Photoacoustic imaging uses short-pulse lasers as the excitation source, and uses ultrasonic transducers to detect different ultrasonic signals generated by uneven absorption of light by different tissues. It has high resolution, high contrast, no damage, and no ionization effects. It also has the advantages of deep detection depth and high resolution of ultrasonic imaging. [0003] Among them, optical resolution photoacoustic microscopy imaging is a newly developed imaging technology, which can realize high-resolution detection images on the scale of hundreds of microns to tens of nanometers, and has high optical contrast, no radiation damage, and is safe and convenient to use. and other advantages, its lateral resolution is mainly determined by the focal spot siz...

Claims

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Application Information

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IPC IPC(8): G01N21/17
Inventor 曾吕明杨迪武纪轩荣
Owner 曾吕明
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