Optical resolution type photoacoustic microscope based on optical beam scanning

Abstract

The invention provides an optical resolution type photoacoustic microscope based on optical beam scanning. The photoacoustic microscope comprises a laser diode, a collimating lens, a multidimensional laser galvanometer, a focusing lens, a rectangular prism, a coupling liquid box, an ultrasonic coupling liquid, a film, a shell, a lifting platform, an ultrasonic sensor, a signal processing circuit, a data acquisition circuit, a computer, a galvanometer driving circuit, a clock circuit and a driving power circuit. According to the invention, miniature, inexpensive and easily maintained laser diode is applied to the field of optical resolution forward photoacoustic microscopy excitation, and the laser galvanometer is used to realize substitution of mechanical scanning by beam scanning to achieve fast imaging. The photoacoustic microscope has the advantages of portable volume, high resolution and fast imaging, and can be widely applied to photoacoustic microimaging in the fields of material detection, industrial inspection and medical image.

Description

technical field [0001] The invention relates to a photoacoustic microscopic imaging technology, in particular to an optical resolution photoacoustic microscope based on beam scanning. Background technique [0002] Photoacoustic imaging uses short-pulse lasers as the excitation source, and uses ultrasonic transducers to detect different ultrasonic signals generated by uneven absorption of light by different tissues. It has high resolution, high contrast, no damage, and no ionization effects. It also has the advantages of deep detection depth and high resolution of ultrasonic imaging. [0003] Among them, optical resolution photoacoustic microscopy imaging is a newly developed imaging technology, which can realize high-resolution detection images on the scale of hundreds of microns to tens of nanometers, and has high optical contrast, no radiation damage, and is safe and convenient to use. and other advantages, its lateral resolution is mainly determined by the focal spot siz...

AI Technical Summary

Problems solved by technology

The above reports all use laser galvanometers to realize beam scanning instead of mechanical scanning to achieve fast imaging, but they all use relatively high-power solid-state lasers as photoacoustic excitation sources, and such lasers usually have large volume, high price, There are many shortcomings such as difficult maintenance, and it is difficult to realize the miniaturization and portable design of the system, which obviously has considerable limitations in practical applications

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