Nanometer magnesium oxide inorganic antibacterial agent, preparation method and applications of nanometer magnesium oxide inorganic antibacterial agent

An inorganic antibacterial agent and nano-magnesium oxide technology, applied in the field of antibacterial agents, can solve problems such as the preparation process of nano-magnesium oxide functional powder that has not yet been developed, and achieve the effects of easy industrial production, improved antibacterial performance, and enhanced antibacterial performance.

Active Publication Date: 2013-01-23
INST OF PROCESS ENG CHINESE ACAD OF SCI
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  • Claims
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AI Technical Summary

Problems solved by technology

[0005] From the above-mentioned development of nano-magnesia preparation technology, so far, the main focus of preparation technology is still limited to the control of particle size, and the preparation of nano-magnesia functional powder suitable for sterilization has not been developed from the adjustment of particle surface properties. craft

Method used

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  • Nanometer magnesium oxide inorganic antibacterial agent, preparation method and applications of nanometer magnesium oxide inorganic antibacterial agent

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Experimental program
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Effect test

Embodiment 1

[0048] According to Cu 2+ with Mg 2+ The molar ratio is 0.01, Cu(CH 3 COO - ) 2 ·H 2 Mix 20ml of ethanol solution of O with 80ml of 0.5mol / L magnesium nitrate ethanol solution, stir evenly at room temperature; then add 100ml of ethanol solution containing equimolar concentration of oxalic acid into the above mixed solution, and continue stirring at 600rpm for 30min , after aging at room temperature for 12 hours, the precursor gel was obtained; after the gel was filtered and washed with ethanol for 3 to 5 times, it was dried at 100°C for 24 hours to obtain the dry gel of the magnesium oxide precursor. Finally, the obtained xerogel is sintered at a high temperature of 500° C. for 2.5 hours in an air atmosphere to obtain a copper ion-doped nano magnesium oxide inorganic antibacterial agent. After measurement, the particle size, specific surface area, 24h bactericidal rate against Escherichia coli, MIC value and antibacterial rate of Staphylococcus aureus are as in sample S-1...

Embodiment 2

[0050] According to Cu 2+ with Mg 2+ The molar ratio is 0.05, Cu(NO 3 ) 2 ·3H 2 20ml of ethanol solution of O and 80ml of 0.3mol / L magnesium nitrate ethanol solution are mixed directly, and stirred evenly at room temperature; after that, 100ml of ethanol solution containing equimolar concentration of oxalic acid is directly added to the above mixed solution, and continuously stirred at 700rpm for 30min Finally, after aging at room temperature for 12 hours, the precursor gel was obtained; after the gel was filtered and washed with ethanol for 3 to 5 times, it was dried at 100°C for 24 hours to obtain the dry gel of the magnesium oxide precursor. Finally, the obtained xerogel is sintered at a high temperature of 500° C. for 5 hours in an air atmosphere to obtain a copper ion-doped nano magnesium oxide inorganic antibacterial agent. After measurement, the particle size, specific surface area, 24h bactericidal rate against Escherichia coli, Staphylococcus aureus MIC value and ...

Embodiment 3

[0052] According to Cu 2+ with Mg 2+ The molar ratio is 0.02, Cu(SO 4 ) 2 ·5H 2 Directly mix 20ml of ethanol solution of O with 80ml of 0.2mol / L magnesium nitrate ethanol solution, and stir evenly at room temperature; then, directly add 100ml of ethanol solution containing equimolar concentration of oxalic acid into the above mixed solution, and continue stirring for 30min at 800rpm Finally, after aging at room temperature for 12 hours, the precursor gel was obtained; after the gel was filtered and washed with ethanol for 3 to 5 times, it was dried at 100°C for 24 hours to obtain the dry gel of the magnesium oxide precursor. Finally, the obtained xerogel is sintered at a high temperature of 500° C. for 2 hours in an air atmosphere to obtain a copper ion-doped nano magnesium oxide inorganic antibacterial agent. After measurement, the particle size, specific surface area, 24h bactericidal rate against Escherichia coli, Staphylococcus aureus MIC value and antibacterial rate a...

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Abstract

The invention relates to a nanometer magnesium oxide inorganic antibacterial agent, a preparation method and applications of the nanometer magnesium oxide inorganic antibacterial agent. The method comprises the steps of mixing magnesium salt alcoholic solution containing copper ions and oxalic acid alcoholic solution at room temperature, and reacting to obtain precursor gel containing copper ions; ageing, separating and drying the gel, then conducting high-temperature calcination on the gel under air atmosphere to obtain ion-doped nanometer magnesium oxide inorganic antibacterial agent. The diameters of the antibacterial agent particles are controlled to be 5-30nm, the specific surface area is 26.4-258.0m2/g, the antibacterial rate of the antibacterial agent to representative gram-negative colon bacillus and gram-positive staphylococcus aureus in 24 hours can be more than 99.9%, and along with the increasing of the diameters of the particles, the minimal inhibitory concentration is lower and lower gradually, and the good antibacterial capability can be displayed. The nanometer magnesium oxide inorganic antibacterial agent and the preparation method have the advantages that the antibacterial capability can be controlled by utilizing the doped ions, the requirement on the diameter range of the particles is low, the requirement on the preparation process and equipment can be lowered greatly, raw materials are easy to obtain, the operation is easy, the yield is high, the nanometer magnesium oxide inorganic antibacterial agent is suitable for large-batch preparation.

Description

technical field [0001] The invention relates to the technical field of antibacterial agents, in particular to a nano-magnesia inorganic antibacterial agent, a preparation method and an application. Background technique [0002] Nano-magnesium oxide particles have excellent destructive adsorption capacity and surface reactivity due to their ultra-fine particle size, large specific surface area, special edges, corners, junctions and surface defect states (Mishakov I.V.et al.CF 2 Cl 2 Decomposition over Nanocrystalline MgO:Evidence for Long Induction Periods.Journal of Physical Chemistry.B 2005,109,6982-6989;Portillo R.et al.Magnesia Synthesis via Sol-Gel:Structure and Reactivity.Langmuir,1996,12,40- 44), therefore, nano-magnesium oxide is easy to interact with microbial cells, destroy the cell wall, and exhibit excellent antibacterial ability (Stoimenov P.K. Metal Oxide Nanoparticles as Bactericidal Agents. Langmuir 2002, 18, 6679-6686). The sterilization and disinfection ab...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N59/20A01P1/00
Inventor 陈运法武晓峰
Owner INST OF PROCESS ENG CHINESE ACAD OF SCI
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