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Method for preparing lutein crystals from marigold ointment by catalytic saponification

A technology of lutein and marigold, which is applied in the direction of organic chemistry, can solve the problems of polluting the environment and dealing with complex problems, and achieve the effects of reducing pollution, reducing purification steps, and improving purity and yield

Inactive Publication Date: 2013-01-23
CHANGSHA FENKANG BIOLOGICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these methods all require saponification with an alkaline solution with a relatively high concentration (usually about 40% in actual industrial production), or use a variety and / or a large amount of organic washing solvents, resulting in complicated follow-up treatment and environmental pollution.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Weigh 100g of marigold ointment with a total carotenoid content of 15.2%, mix it with 200ml of 5% sodium methoxide methanol solution, heat it to 65°C, and then add 2% strong basic anion resin based on the mass of marigold ointment D201, continue to keep stirring and catalyze the saponification reaction for 7h. Add 200ml of deionized water, keep the temperature at 40°C, stir, crystallize, and filter to obtain crude lutein crystals.

[0017] The obtained crude lutein crystal was washed with 30ml of petroleum ether and ethyl acetate with a volume ratio of 1:1, then washed with 30ml of absolute ethanol, and dried in vacuo to obtain 14.2g of lutein crystal powder, which was detected by HPLC , the total carotenoid content is 91.23%, the lutein purity is 82.17%, and the product yield is 93.42%.

Embodiment 2

[0019] Weigh 100g of marigold ointment with a total carotenoid content of 15.2%, mix it with 200ml of 5% sodium methoxide methanol solution, heat it to 65°C, and then add 2% strong basic anion resin based on the mass of marigold ointment D204, continue to keep stirring and catalyze the saponification reaction for 7h. Add 200ml of deionized water, keep the temperature at 40°C, stir, crystallize, and filter to obtain crude lutein crystals.

[0020] The obtained crude lutein crystals were washed with a mixed solution of 30ml n-hexane and ethyl acetate with a volume ratio of 1:1, then washed with 30ml absolute ethanol, and vacuum-dried to obtain 13.4g lutein crystal powder, which was detected by HPLC , the total carotenoid content is 89.43%, the lutein purity is 80.37%, and the product yield is 88.15%.

Embodiment 3

[0022] Weigh 100g of marigold ointment with a total carotenoid content of 15.2%, mix it with 200ml of 5% sodium methoxide methanol solution, heat it to 65°C, and then add 2% strong basic anion resin based on the mass of marigold ointment D204, continue to keep stirring and catalyze the saponification reaction for 7h. Add 200ml of deionized water, keep the temperature at 40°C, stir, crystallize, and filter to obtain crude lutein crystals.

[0023] The obtained crude lutein crystal was washed with a mixed solution of 30ml petroleum ether and ethyl acetate in a volume ratio of 1:2, then washed with 30ml absolute ethanol, and dried in vacuum to obtain 12.2g lutein crystal powder, which was detected by HPLC , the total carotenoid content is 93.43%, the lutein purity is 82.37%, and the product yield is 80.26%.

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PUM

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Abstract

The invention provides a method for preparing lutein crystals from marigold ointment by catalytic saponification. A mixture of one or more of KOH, NaOH, sodium methoxide and sodium ethylate and alkaline ionic resin is preferably used as a saponification catalyst, and small amounts of deionized water and low-polarity solvent are utilized to clean the lutein crystal crude product, wherein the low-polarity solvent is preferably one or more of petroleum ether, n-hexane and ethyl acetate. Compared with the traditional method, the method provided by the invention greatly reduces the organic cleaning solvent, simplifies the after-treatment technique, and reduces the environmental pollution. The preparation method of the lutein crystals has the advantage of simple and stable technique, and is suitable for industrial large-scale production; and the purity and yield of the prepared lutein crystals are respectively up to 82% and 90% above.

Description

technical field [0001] The invention relates to the field of preparation of lutein, in particular to a method for preparing lutein crystals by catalytic saponification of marigold ointment. Background technique [0002] Lutein is a carotenoid that is widely found in natural plants, such as vegetables, fruits, grains and certain algae, especially in the petals of marigold. Lutein has strong antioxidant properties and can scavenge or inhibit free radicals that cause tissue damage and cell aging in the human body, so it can be used as food, medicine or health care products to prevent senile vision loss, cardiovascular diseases, tumors, etc. disease. In addition, because lutein has the advantages of bright color, strong coloring power, and rich nutrition, it is widely used as food coloring agent and nutritional fortifier. It can be seen that lutein can play an important role in human daily life, and its application breadth and depth will continue to deepen. Therefore, the deve...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C403/24
Inventor 李芬芳
Owner CHANGSHA FENKANG BIOLOGICAL TECH
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