Particle size controllable mono-disperse polyacrylamide gel microspheres and preparation method as well as used device thereof

A polyacrylamide gel microsphere and polyacrylamide gel technology, which are used in the preparation of microspheres, microcapsule preparations, chemical instruments and methods, etc.

Inactive Publication Date: 2013-01-30
UNIV OF SCI & TECH OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the limitation of capillary size, it is usually difficult to prepare microspher

Method used

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  • Particle size controllable mono-disperse polyacrylamide gel microspheres and preparation method as well as used device thereof
  • Particle size controllable mono-disperse polyacrylamide gel microspheres and preparation method as well as used device thereof
  • Particle size controllable mono-disperse polyacrylamide gel microspheres and preparation method as well as used device thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] A capillary-based fluid focusing microfluidic control device, which includes a dispersed phase injector 2-2, a continuous phase injector 2-1, a dispersed phase driven pump 1-2, a continuous phase driven pump 1-1, a T-shaped tee 5, The polymerization reaction vessel 10, the dispersed phase injector 2-2 and the continuous phase injector 2-1 are respectively installed on the dispersed phase driven pump 1-2 and the continuous phase driven pump 1-1, and are respectively connected to the T-type via conduits 3 and 4. The two ports of the tee are connected; wherein, the third port of the T-shaped tee is connected with a conduit 6, and the liquids in the dispersed phase injector 2-2 and the continuous phase injector 2-1 are collected in this conduit 6 and then flow into Polymerization reaction vessel 10.

[0048] Wherein, the three ports of the T-shaped tee 5 are respectively provided with internal threads;

[0049] The outside of the end of the continuous phase injector 2-1 an...

Embodiment 2

[0056] 10g of polyacrylamide, 0.3g of N,N'-methylenebisacrylamide, and 0.2g of ammonium persulfate were dissolved in 89.5g of deionized water to form a dispersed phase solution. Use simethicone as the continuous phase material.

[0057] Put the above-mentioned dispersed phase solution and continuous phase solution into 1mL and 50mL syringes respectively, place them on two push pumps, connect the microfluidic controller, and set the flow rate of the dispersed phase to 2 μL min -1 , viscosity 30mPa·s, continuous phase flow rate 60μL·min -1 , viscosity 600mPa·s, capillary 1 size: outer diameter / inner diameter 245 / 98 μm, capillary 2 size: outer diameter / inner diameter 670 / 430 μm, turn on the microfluidic control device, prepare monodisperse reactant solution droplets; collect the generated The droplets are incubated in a water bath at 75°C for 1 hour, and the reactant droplets can be polymerized into polyacrylamide gel microspheres. After simple decanting, the residual organic s...

Embodiment 3

[0059] 10g of polyacrylamide, 0.3g of N,N'-methylenebisacrylamide, and 0.2g of ammonium persulfate were dissolved in 89.5g of deionized water to form a dispersed phase solution. Use simethicone as the continuous phase material.

[0060] Put the above-mentioned dispersed phase solution and continuous phase solution into 1mL and 50mL syringes respectively, place them on two push pumps, connect to the microfluidic controller, and set the flow rate of the dispersed phase to 4 μL min -1 , viscosity 30mPa·s, continuous phase flow rate 50μL·min -1 , viscosity 600mPa·s, capillary 1 size: outer diameter / inner diameter 245 / 98 μm, capillary 2 size: outer diameter / inner diameter 665 / 531 μm, turn on the microfluidic control device, prepare monodisperse reactant solution droplets; collect the generated The droplets are incubated in a water bath at 75°C for 1 hour, and the reactant droplets can be polymerized into polyacrylamide gel microspheres. After simple decanting, the residual organi...

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Abstract

The invention provides a preparation method of particle size controllable mono-disperse polyacrylamide gel microspheres. The preparation method comprises the following steps of: preparing disperse phase solution and continuous phase solution; controlling flow velocities and viscosities of the disperse phase and the continuous phase; and converging the disperse phase and the continuous phase to obtain polyacrylamide solution droplets with different particle sizes and uniform diameter size, wherein the droplets are subjected to polymerization reaction to obtain the particle size controllable mono-disperse polyacrylamide gel microspheres. The invention also relates to a preparation device of the particle size controllable mono-disperse polyacrylamide gel microspheres and the mono-disperse polyacrylamide gel microspheres obtained thereby. By adjusting the flow velocities and the viscosities of the disperse phase and the continuous phase or the size of capillary tubes, accurate control over the particle size of the microspheres can be realized; and the particle size of the prepared microspheres is within a range of 10-1,000 mum.

Description

technical field [0001] The invention relates to the field of preparation of monodisperse microspheres, in particular to a monodisperse polyacrylamide gel microsphere with controllable particle size, a preparation method and a device thereof. Background technique [0002] Polyacrylamide microspheres have the characteristics of large specific surface area, strong surface reaction ability, easy functionalization and good biocompatibility, and have broad application prospects in many fields. The monodisperse polyacrylamide microspheres with uniform particle size have important uses in analytical chemistry, biochemistry, immunomedicine, standard metrology and other high-tech fields that have ultra-high requirements for polyacrylamide particle size and particle size distribution. [0003] The traditional preparation methods of polyacrylamide microspheres include inverse suspension polymerization, inverse emulsion polymerization, dispersion polymerization and other preparation meth...

Claims

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Application Information

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IPC IPC(8): C08F220/56C08F222/38C08F220/06C08F220/34C08J9/28B01J13/14B01J19/00
Inventor 常振旗
Owner UNIV OF SCI & TECH OF CHINA
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