Modified film material for bioartificial liver

A technology of bioartificial and membrane materials, applied in medical science, prostheses, suction devices, etc., can solve the problem of not being able to better maintain the function of primary liver cells, so as to facilitate the maintenance of adherent growth and functional state, pro- good water effect

Inactive Publication Date: 2013-02-06
程向东
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  • Abstract
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Problems solved by technology

However, single application of PVDF membrane cannot better maintain the function of primary liver cells

Method used

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  • Modified film material for bioartificial liver

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Embodiment Construction

[0028] The present invention will be further described below in conjunction with the drawings and specific embodiments, but the protection scope of the present invention is not limited to this.

[0029] The specific steps for preparing the modified membrane material are:

[0030] (1) Pretreatment of membrane:

[0031] Cut the polyvinylidene fluoride hollow fiber membrane into 5 small sections of 10cm, put them in a petri dish, soak in 95% ethanol for 24h, rinse with deionized water, dry under vacuum at 60°C to constant weight, and weigh its weight W 0 ; Then immerse the PVDF membrane in a 3.0% ethanol solution of the photosensitizer benzophenone, take it out after 2h, and prepare a PVDF membrane pre-covered with a photosensitizer;

[0032] (2) The grafting reaction of PVDF membrane:

[0033] Place a 20% ethanol solution of 2-methyl-2-acrylic acid-2-(2-methoxyethoxy)ethyl ester in a quartz tube, and then place a small section of PVDF membrane in the quartz tube ; At 25℃, irradiate with ...

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Abstract

The invention relates to a modified film material for a bioartificial liver. The modified film material is prepared by the following steps of: by taking a polyvinylidene fluoride hollow fiber film as a raw material, taking 2-methyl-2-acrylic acid-2-(2-methoxyethoxy) ethyl ester as a grafting monomer and taking benzophenone as an initiator, performing surface graft modification on the polyvinylidene fluoride hollow fiber film by employing an ultraviolet irradiation method. The modified film material has high hydrophilcity; compared with the unmodified film material in a miniature artificial liver reactor, the modified film material contributes to adherent growth of hepatic cells and maintenance of functional status and is suitable for serving as a film material of the bioartificial liver.

Description

Technical field [0001] The invention belongs to the technical field of medical biochemical engineering, and particularly relates to a modified membrane material for bioartificial liver. Background technique [0002] Acute liver failure (ALF) can cause severe damage or necrosis of liver cells, which is the most challenging clinical syndrome. At present, liver transplantation is the only cure for acute liver failure. However, due to the lack of donors and the limitation of donor storage time, in addition, due to economic and technical reasons, conventional liver transplantation is not suitable for most patients. Realistic. [0003] In 1986, Professor Demetrion first proposed the concept of bioartificial liver (BAL), which combines a suspension of liver cells with biosynthetic materials to assemble a certain form of artificial liver support system, and found that it is not only liver-specific The detoxification function, and it has obvious functions in participating in the metabolis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/18C08J7/00C08L27/16A61L27/16A61M1/18
Inventor 程向东项海刘文洪蒋永生
Owner 程向东
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