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High-concentration collagen sponge wound protection paste and preparation method thereof

A technology of collagen sponge and collagen sponge, which is applied in the field of high-concentration collagen sponge bandage and its preparation, can solve the problem that the wound surface with strict disinfection requirements cannot be taken into account, the accelerated healing and repair effect cannot be achieved, and it is easy to cause heat and pathogenicity. Accelerate skin metabolism, reduce skin scar formation, and achieve excellent cross-linking effects

Active Publication Date: 2014-07-23
GUANGZHOU TRAUER BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some absorbent pads are often composed of gauze, sponges and other items, among which gelatin sponge and low-concentration collagen sponge have been used. The disadvantages of these sponges are: low purity, low activity, strong antigenicity, low safety, and easy to cause carcinogenesis. Heat and sensitization reactions, and the desired accelerated healing and repair effects for slightly larger and deeper wounds are not yet achieved
[0003] The current structural design of the bandage is generally relatively simple, and there are more or less problems at the same time, such as the wound surface is easily contaminated during use, and the wound surface that requires strict disinfection cannot be taken into account. Therefore, it is still necessary to further improve

Method used

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  • High-concentration collagen sponge wound protection paste and preparation method thereof
  • High-concentration collagen sponge wound protection paste and preparation method thereof
  • High-concentration collagen sponge wound protection paste and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Please refer to figure 1 , figure 2 Shown, a kind of high-concentration collagen sponge protects band-aid, and its structure comprises medical base cloth layer 5, is attached to the outer isolation layer 1 on this medical base layer 5, is respectively attached to this medical base cloth layer 5 surface and is The stepped first inner insulation layer 2 and the second inner insulation layer 3, a water-absorbent cushion layer 4 mainly composed of a high-concentration collagen sponge, the water-absorbent cushion layer 4 is attached to the medical base cloth layer 5, and The first inner isolation layer 2 and the second inner isolation layer 3 are non-bonded; and the easy pull label 6 adhered to the edge of the outer isolation layer 1 .

[0046] figure 2Shown is a square medical base cloth layer 5 and an easy pull label 6 attached to the medical base cloth layer 5 . The inner or upper layer of the outer isolation layer 1 is attached to the non-adhesive side of the medica...

Embodiment 2

[0060] Please refer to figure 1 , image 3 Shown, a kind of high-concentration collagen sponge protects bandage, and its structure comprises outer isolation layer 1, first inner isolation layer 2, second inner isolation layer 3, composite collagen sponge with high-concentration collagen liquid and medicine compound It is the water-absorbing cushion layer 4 of the main body, the medical base cloth layer 5 and the easy-to-pull label 6. The inner or upper layer of the outer isolation layer 1 is attached to the non-adhesive side of the medical base cloth layer 5, and the outer edges of the adhesive surface of the medical base cloth layer 5 adhere to the first inner isolation layer 2 and the second inner isolation layer respectively. The outer edge of the layer 3, the central part of the adhesive surface of the medical base cloth layer 5 adheres to one side of the water-absorbing cushion layer 4, and the other side of the water-absorbing cushion layer 4 is respectively composed of...

Embodiment 3

[0075] The high-concentration collagen sponge bandage of the present embodiment has the same structure as the above-mentioned embodiment 2.

[0076] The water-absorbing cushion layer is a composite collagen sponge, which is a sponge-like article formed by high-concentration collagen stock solution under low-temperature freezing conditions and obtained by cross-linking.

[0077] The extracting method of this collagen comprises the following steps:

[0078] (1) Pretreatment: take 20g of beef tendon raw material, remove epidermis, muscle, fat, etc., wash and mash;

[0079] (2) Acidic enzymatic hydrolysis: add 10 times the volume of 0.5M acetic acid containing 1.2% pepsin, stir, and enzymatically hydrolyze at 4°C for 72 hours;

[0080] (3) Termination of enzymolysis: Centrifuge the enzymolysis solution at 10,000 rpm, 4°C for 20 minutes, and take the supernatant; add 10 mM EDTA to the supernatant, stir for 1 hour, centrifuge at 10,000 rpm, and 4°C for 20 minutes;

[0081] (4) Neu...

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Abstract

The invention discloses a high-concentration collagen sponge wound protection paste and a preparation method thereof. The high-concentration collagen sponge wound protection paste comprises a medical base cloth layer, a first inner separation layer, a second inner separation layer, a water suction cushion layer and an easily-pulled label, wherein the medical base cloth layer is fitted on an outer separation layer on the medical base cloth layer, the first inner separation layer and the second inner separation layer are respectively fitted with a surface of the medical base cloth layer and of step-shaped, the water suction cushion layer uses high-concentration collagen sponge to serve as a main body, the water suction cushion layer is pasted on the medical base cloth layer, and the easily-pulled label is pasted at the edge of the outer separation layer. The water suction cushion layer is the high-concentration collagen sponge or composite collagen sponge compounded by high-concentration collagen liquid and medicines, the high-concentration collagen is high in purity, hydroxyproline content achieves 11%, a collagen structure is completely kept, mechanical hemostasis is achieved after the wound protection paste is contacted with a wound, simultaneously physiological coagulation can be induced, and wound recovery is promoted. The high-concentration collagen sponge wound protection paste has the advantages of being convenient and healthy in use and having hemostasis recovery effects and retaining scars.

Description

technical field [0001] The invention relates to a medical product capable of promoting hemostasis and repair of wounds, in particular to a high-concentration collagen sponge bandage and a preparation method thereof. Background technique [0002] Bandage is a medical dressing composed of medical base cloth, absorbent pad and isolation film, mainly used to protect various wounds and isolate external infections. Some absorbent pads are often composed of gauze, sponges and other items, among which gelatin sponge and low-concentration collagen sponge have been used. The disadvantages of these sponges are: low purity, low activity, strong antigenicity, low safety, and easy to cause carcinogenesis. Heat and sensitization reactions, and the desired accelerated healing and repair effects on slightly larger and deeper wounds have not yet been achieved. [0003] The structure design of the current bandages is generally relatively simple, and there are more or less problems at the same...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F13/15A61L15/32A61L15/42A61L15/44C12P21/06
Inventor 盛晓晓熊书武李琪冯雪莉雷静黄冬晶
Owner GUANGZHOU TRAUER BIOTECH