Piribedil sustained release preparation and preparation method thereof

A technology of piribedil and sustained-release preparations, which is applied in the field of biopharmaceuticals, can solve the problems of large waste of raw materials, achieve rapid absorption, improve painful symptoms, and have significant curative effects

Inactive Publication Date: 2013-02-27
KAIFENG BAIYUN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The raw material of piribedil administered through the nose is too much waste

Method used

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  • Piribedil sustained release preparation and preparation method thereof
  • Piribedil sustained release preparation and preparation method thereof

Examples

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Effect test

Embodiment 1

[0028] The piribedil sustained-release preparation of the present invention is expressed in parts by weight g, and 1000 piribedil sustained-release preparations are prepared from 50 g of piribedil, 95 g of lactose, 34 g of hypromellose, and 60% concentration by mass. It is composed of 0.15 g of water and ethanol mixed solution and 0.5 g of magnesium stearate.

Embodiment 2

[0030] The piribedil sustained-release preparation of the present invention is expressed in parts by weight g, and 1000 piribedil sustained-release preparations are prepared from 45 g of piribedil, 105 g of lactose, 32 g of hypromellose, and 65% of mass percent concentration. It is composed of 0.12g of water and ethanol mixed solution and 0.35g of magnesium stearate.

Embodiment 3

[0032] The piribedil sustained-release preparation of the present invention is expressed in parts by weight g, and 1000 piribedil sustained-release preparations are prepared from 40 g of piribedil, 90 g of lactose, 25 g of hypromellose, and 70% of mass percent concentration. It is composed of 0.1g of water and ethanol mixed solution and 0.25g of magnesium stearate.

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Abstract

The invention discloses a piribedil sustained release preparation and a preparation method thereof. The piribedil sustained release preparation comprises 40-50 weight parts of piribedil, 90-120 weight parts of filling agent, 25-40 weight parts of sustained release material, 0.1-0.2 weight parts of binding agent, and 0.25-0.5 weight parts of lubricant. The preparation method comprises the following steps: firstly respectively crushing piribedil, the filling agent and the sustained release material and fully mixing to obtain mixed powder; then adding the binding agent and uniformly mixing to obtain a soft material; preparing the soft material into wet particles, and drying to obtain dry particles; and adding the lubricant to prepare into piribedil sustained release tablets. According to the invention, the piribedil sustained release preparation disclosed herein can effectively reduce the peak plasma concentration and prolong the action time of the drug, so as to improve the pathological cognition and sensory nerve dysfunction of patients and improve the pain symptoms caused by arterial disease of patients, and the curative effect is significant.

Description

technical field [0001] The invention belongs to the technical field of biopharmaceuticals, in particular to a piribedil sustained-release preparation and a preparation method thereof. Background technique [0002] Pirabedil belongs to the peripheral and cerebral vasodilator drugs, used for the treatment of Parkinson's disease and circulatory disorders, the chemical name is piribedil, [(methylenedioxy-3,4 benzyl)-4 piperazine Base-1]-2 pyrimidine, whose molecular formula is C 16 h 18 N 4 o 2 , the molecular weight is 298.3, and the structural formula is: [0003] [0004] Pirabedil is a white to off-white crystalline powder, and piribedil is a selective D2 / D3 dopa [0005] Aminergic agonist, which can stimulate the post-synaptic D2 receptors in the nigrostriatum and the D2 and D3 receptors in the mesencephalic cortex, mesolimbic pathway, providing potent dopamine effects, administered as oral tablets, The trade name in France is Tashuda, and the specification is 50m...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K9/22A61K31/506A61P9/08A61P25/16A61P25/00
Inventor 刘志庆王斐朱赞梅张宝国高攀攀王新房
Owner KAIFENG BAIYUN PHARMA CO LTD
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