A kind of benzimidazole derivative and its preparation method and application
A technology of benzimidazole and derivatives is applied in the fields of benzimidazole derivatives and their preparation and application, and achieves the effects of reducing fasting blood sugar, promoting growth activity, and promoting yeast growth
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[0041] The present invention will be further described in detail below through the specific examples, the following examples are only descriptive, not restrictive, and cannot limit the protection scope of the present invention with this.
[0042] The reagents used in this example are all commercially available products unless otherwise specified; the methods used are all conventional methods unless otherwise specified; the instruments used are all conventional instruments unless otherwise specified.
[0043] The principle of the present invention is based on the high homology between yeast Sir2 and mammalian SIRT1, and proves that benzimidazole derivatives, that is, compound 2-m-anilinobenzimidazole-1H-pyrazole-3-carboxamide (JHJ3 for short) can promote The yeast grows, enhances its metabolic activity, and can significantly reduce the plasma triglyceride, total cholesterol and high-density lipoprotein of C57 BL / 6J mice fed with high-fat diet for a long time, and reduce the systol...
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