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Application of hyaluronic acid metal salt to preparation of skin disease treatment drugs, as well as drug composition and preparation method of hyaluronic acid metal salt

A technology of hyaluronic acid and zinc hyaluronate, applied in the field of medicine and treatment, can solve problems such as large side effects, easy recurrence, skin atrophy and the like

Inactive Publication Date: 2013-03-13
程玉李
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, clinically, symptomatic anti-inflammatory treatment is mainly used for skin barrier dysfunction. Anti-inflammatory drugs often use hormone drugs. These drugs have fast onset and obvious curative effects, but they also have large side effects. Long-term use can easily lead to thinning of the skin. Adverse reactions such as skin atrophy and easy recurrence after drug withdrawal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Sodium Hyaluronate -----0. 2g Simethicone Oil -----------15g

[0074] Stearic acid ------------15g Glyceryl monostearate ----- 3g

[0075] Liquid paraffin----------9 g White petrolatum------------7g

[0076] Sodium Lactate-------------3 g Glycerin---------------------5g

[0077] Triethanolamine ---------2 g Ethylparaben ------------0.1g

[0078] Carbomer ------------ 0.5 g purified water added to 100g

[0079] Operation process:

[0080] ⑴. Take sodium hyaluronate according to the formula ratio, add some water to dissolve;

[0081] ⑵. Put silicone oil, stearic acid, glyceryl monostearate, liquid paraffin, and white petrolatum in a stirring pot, and heat to about 80°C to melt into an oil phase;

[0082] ⑶. Take the remaining water, glycerin, carbomer glue, ethylparaben, sodium lactate, and triethanolamine and put them in a stirring pot, and heat to 80°C to form the water phase;

[0083] ⑷. Slowly add the oil phase to the water phase, stop heating...

Embodiment 2

[0085] Zinc hyaluronate---0.01-3g; Dimethicone-------1-30g;

[0086] Stearic acid------10-30g; Glyceryl monostearate----1-15g;

[0087] Liquid paraffin ------- 2-20 g; White petrolatum ------------- 5-20 g;

[0088] Lanolin---------1-10g; Glycerin------------------1-20g

[0089] Triethanolamine------1-10g; Ethylparaben------------0.05-0.5g;

[0090] Carbomer---------0.5 g; add purified water to 100g.

[0091] Operation process:

[0092] ⑴. Take zinc hyaluronate according to the formula ratio, add some water to dissolve;

[0093] ⑵. Put silicone oil, stearic acid, glyceryl monostearate, liquid paraffin, white petrolatum, and lanolin in a stirring pot, and heat to about 80°C to melt into an oil phase;

[0094] ⑶. Take the remaining water, glycerin, carbomer glue, ethylparaben, and triethanolamine in a stirring pot, and heat to 80°C to form the water phase;

[0095] ⑷. Slowly add the oil phase to the water phase, stop heating, and stir. When the tempera...

Embodiment 3

[0097] Sodium hyaluronate----------0.01—3g; Zinc hyaluronate 0.01—3g

[0098] Dimethicone-------1-30g; Stearic acid----------1-30g;

[0099] Glyceryl monostearate ---- 1-15g; Liquid paraffin ------- 2-20 g;

[0100] White petrolatum --------------1-20g; Lanolin---------1-10g;

[0101] Glycerin------------------1—20g Triethanolamine------1—10g;

[0102] Ethylparaben -----------0.05—0.5g; Carbomer --------0.5—5 g;

[0103] Purified water was added to 100 g.

[0104] Operation process:

[0105] ⑴. Take zinc hyaluronate according to the formula ratio, add some water to dissolve;

[0106] ⑵. Put silicone oil, stearic acid, glyceryl monostearate, liquid paraffin, white petrolatum, and lanolin in a stirring pot, and heat to about 80°C to melt into an oil phase;

[0107] ⑶. Take the remaining water, glycerin, carbomer glue, ethylparaben, and triethanolamine in a stirring pot, and heat to 80°C to form the water phase;

[0108] ⑷. Slowly add the oil phase ...

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Abstract

The invention relates to an application of hyaluronic acid metal salt to preparation of skin disease treatment drugs, as well as a drug composition and a preparation method of the hyaluronic acid metal salt. The invention discloses a new application of the hyaluronic acid metal salt. The hyaluronic acid metal salt is one or two of zinc hyaluronate and / or sodium hyaluronate. The hyaluronic acid metal salt is of a drug composition form; and the drug composition (total 100 parts by weight) comprises 0.01-5 parts by weight of hyaluronic acid metal salt. The invention also discloses a preparation method of the hyaluronic acid metal salt drug composition for treating skin diseases. The new application of the hyaluronic acid metal salt and the drug composition are mainly used for treating the skin barrier function injuries / turbulence and concomitant clinic symptoms such as inflammation, dry, erythema, desquamation, pruritus and the like, and have a definite curative effect and high safety.

Description

technical field [0001] The invention belongs to a new application patent in the field of medical treatment, and relates to the application of a metal hyaluronic acid salt in the preparation of a drug for treating skin diseases, the pharmaceutical composition in the application, and the metal hyaluronic acid for treating skin diseases Preparation method of salt pharmaceutical composition. It specifically relates to a pharmaceutical composition containing zinc hyaluronate and / or sodium hyaluronate, which is used for treating various clinical symptoms of skin barrier function damage / disorder caused by various physical and chemical factors. Background technique [0002] Skin barrier broadly includes physical barrier, pigment barrier, nerve barrier, and immune barrier. In the narrow sense, it mainly refers to physical barriers, and we usually talk about physical barriers. The physical barrier is composed of sebum film, stratum corneum keratin, lipid, "sandwich" structure, brick...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/728A61P17/00A61P17/04A61P17/16A61P29/00
Inventor 程玉李
Owner 程玉李
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