Preparation method of water-soluble probenecid salt

Abstract

The invention discloses a preparation method of a water-soluble probenecid salt. The preparation method comprises the following steps in sequence: reacting probenecid with an alkaline matter in water to obtain the probenecid salt; separating out the probenecid salt from the reaction liquid by controlling the temperature and pH (Potential of Hydrogen) of reaction liquid; and filtering and drying, so as to obtain the probenecid salt. The preparation method is completely carried out under a water phase, no other organic solvents are adopted, no 'three wastes' are brought basically, and the solvent recovery processes are reduced; the production cost and environmental pollution are greatly reduced through the preparation method, and the requirement on clean production is met; the probenecid salt is obtained in a crystallization mode instead of the mode of drying the solvent by distilling, so that other reaction product residues can be avoided, and the production quality and yield of the probenecid salt can be obviously improved.

Description

technical field [0001] The invention relates to a method for preparing water-soluble probenecid salt by using water as a solvent, belonging to the field of chemical synthesis preparation. Background technique [0002] Probenecid, also known as carboxybenzsulfonamide, molecular formula is C 13 h 19 NO 4 S, is a white crystalline powder, soluble in acetone, slightly soluble in ethanol or chloroform, almost insoluble in water, mainly used in the intermission and chronic phase of gout to control hyperuricemia, suitable for increased blood uric acid, renal function It is also used for the treatment of hyperuricemia caused by thiazide diuretics or the risk of gout in patients who are still well and do not excrete much uric acid every day. It is generally not used as an adjuvant treatment for hyperuricemia caused by cancer treatment. Probenecid is insoluble in water and cannot be made into liquid preparations, so its application is limited. Therefore, its water-soluble sodium or...

AI Technical Summary

Problems solved by technology

The method for preparing probenecid sodium in this patent has the following disadvantages: a large amount of dehydration and high energy consumption; the cost of using an organic solvent is greatly increased; the anhydrous organic solvent cannot be directly applied after being used once, and can be reused after rectification and anhydrous treatment or It is directly treated as waste liquid; the amount of precipitated solids is small, the yield is low, and the recovery of raw materials is difficult; the biggest problem is that both absolute ethanol and anhydrous acetone have limited solubility to inorganic alkalis, which directly leads to the difficulty in controlling the amount of residual alkali in the resulting product, which is extremely difficult. Earth affects product quality

The method for preparing probenecid salt in this patent has the following disadvantages: the reaction solution is directly evaporated to dryness without refining, and the residual alkali amount of the obtained product is not easy to control, which greatly affects the product quality; the amount of dehydration is large and the energy consumption is high