Portable type bi-modal imaging method employing combined photoacoustic imaging and optical coherence tomography and system of method

Abstract

The invention provides a portable type bi-modal imaging method employing combined photoacoustic imaging and optical coherence tomography, and a system of the method. The system comprises a laser diode, a driving power supply, a signal generator, a lock phase amplifier, a photoelectric detector, an optical fiber coupler, a light emitting diode, a signal processor, a three-dimensional translation platform, optical fibers, a lens assembly, a reflecting mirror, a color selective mirror, a light path casing and a sample platform and can achieve bi-modal imaging combining combined photoacoustic imaging and optical coherence tomography. The method and the system miniaturize a photoacoustic imaging system, and the photoacoustic imaging system and an optical coherence tomography system are combined to form the integral portable type system, so that integration, miniaturization and practicality of the bi-modal imaging are achieved.

Description

technical field [0001] The present invention relates to a multi-modal imaging technology, in particular to a portable dual-modal imaging method and system combining photoacoustic imaging and optical coherence tomography. Background technique [0002] Currently commonly used single-modal imaging techniques include pure optical imaging (fluorescence imaging, light scattering tomography, etc.), X-ray radiography, nuclide imaging, and magnetic resonance imaging, etc., but these imaging methods can only be based on certain On the one hand, imaging based on the change of characteristics cannot obtain rich information of the sample and its internal correlation in many aspects, which has certain application limitations. [0003] For example, optical coherence tomography (Optical Coherence Tomography, OCT) only reflects the light scattering characteristics of the sample, but generally speaking, the change of the reflectance of the sample to light is very small, and as the penetration...

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Problems solved by technology

[0002] Currently commonly used single-modal imaging techniques include pure optical imaging (fluorescence imaging, light scattering tomography, etc.), X-ray radiography, nuclide imaging, and magnetic resonance imaging, etc., but these imaging methods can only be based on certain On the one hand, imaging based on the change of characteristics cannot obtain the rich information of the sample and its internal correlation in many ways, which has certain application limitations.

[0003] For example, optical coherence tomography (Optical Coherence Tomography, OCT) only reflects the light scattering characteristics of the sample, but generally speaking, the change of the reflectance of the sample to light is very small, and as the penetration depth of light increases, the light in the sample The strong scattering in the medium causes the rapid decline of its imaging spatial resolution, so OCT generally can only achieve a detection depth of 1-5 mm, but the resolution can reach several microns to tens of microns; Photoacoustic Imaging (PAI) only Reflecting the absorption characteristics of the sample to light, it uses a broadband ultrasonic detector to detect ultrasonic waves instead of detecting scattered photons in pure optical imaging, effectively avoiding the strong scattering effect of the sample on light, generally reaching a detection depth of 2-5 cm, and The resolution can reach tens to hundreds of microns; Ultrasonic Imaging (USI) only reflects the acoustic impedance characteristics of the sample, which has the advantage of high penetration, but the imaging contrast is very low, and due to multiple reflections at the sample interface False reflections and sidelobe interference can easily cause misjudgment

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