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Determining method for 15 kinds of forbidden nitro imidazoles antibiotics in cosmetics

A technology for nitroimidazoles and determination methods, which can be applied in the directions of measuring devices, instruments, scientific instruments, etc., can solve the problems of contact dermatitis, drug resistance of nitroimidazoles, hidden dangers to health, etc.

Inactive Publication Date: 2014-04-30
CHINESE ACAD OF INSPECTION & QUARANTINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Illegal addition of nitroimidazoles in acne cosmetics, although it may play a role in removing mites and acne in the short term, long-term use will irritate the skin, cause contact dermatitis, and in severe cases can lead to drug resistance to nitroimidazoles sex, causing health hazards

Method used

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  • Determining method for 15 kinds of forbidden nitro imidazoles antibiotics in cosmetics
  • Determining method for 15 kinds of forbidden nitro imidazoles antibiotics in cosmetics
  • Determining method for 15 kinds of forbidden nitro imidazoles antibiotics in cosmetics

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Embodiment Construction

[0042] To further illustrate the present invention, it will be specifically described in conjunction with the following embodiments:

[0043] 1. Reagents and materials

[0044] 1 Methanol, chromatographically pure.

[0045] 2 Acetonitrile, chromatographically pure.

[0046] 3 Ethanol, analytically pure.

[0047] 4Formic acid, chromatographically pure.

[0048] 54-Nitroimidazole, 97% purity.

[0049] 62-Metronidazole, purity 99%.

[0050] 7-hydroxy metronidazole, purity 99.3%.

[0051] 8-Hydroxydimetridazole, purity 98.5%.

[0052] 9 Metronidazole, purity 99.5%.

[0053] 10 Dimetridazole, purity 98.5%.

[0054] 11 ronidazole, purity 99.5%.

[0055] 12 Ternidazole, purity 99.8%.

[0056] 13 chlorometridazole, 98% purity.

[0057] 14 Bennimidazole, purity 98.5%.

[0058] 15 Secnidazole, purity 99.6%.

[0059] 16 tinidazole, purity 99.7%.

[0060] 17-hydroxypropnidazole, purity 99.8%.

[0061] 18 Ornidazole, 98.5% purity.

[0062] 19 Ipranidazole, purity 99.8%.

[0063] 20 blank cosmetic samples: cosmetics...

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Abstract

The invention relates to a determining method for 15 kinds of forbidden nitro imidazoles antibiotics in cosmetics. The determining method is characterized by comprising the step that a cosmetic sample is subjected to detection analysis by using a high-performance liquid chromatography-series quadrupole mass spectrometry after being subjected to supersonic extraction, high speed centrifugation and solid phase extraction. Compared with a parallelly operated standard sample of the 15 kinds of forbidden nitro imidazoles antibiotics such as metronidazole, the cosmetic sample disclosed in the invention is qualified by retention time and optimized monitoring ion pairs, is quantified by taking ions with a relatively high noise-signal ratio, a good peak form and low background interference as quantified ions, and then is subjected to external standard method quantification by using a standard curve. By utilizing the determining method, the detection speed is fast, and a result is accurate.

Description

Technical field [0001] The present invention relates to metronidazole, 4-nitroimidazole, 2-metronidazole, hydroxy metronidazole, hydroxy dimetronidazole, dimetronidazole, lonidazole, tenidazole and chlorine in cosmetics Metronidazole, Bennidazole, Secnidazole, Tinidazole, Hydroxypropnidazole, Ornidazole, Ipranidazole and other 15 kinds of banned nitroimidazole antibiotics determination methods. Background technique [0002] With the improvement of people's living standards and people's pursuit of beauty, cosmetics, especially some daily skin care, whitening, cleaning products, etc. have become indispensable necessities in people's daily life. Therefore, the safety of cosmetics has increasingly become a hot issue of concern to relevant departments and consumers. [0003] Nitroimidazole antibiotics are widely used to fight anaerobic infections, and also have certain effects on trichomoniasis, acne, and rosacea. Therefore, in order to enhance the anti-acne and whitening effects of c...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06
Inventor 马强孟宪双李文涛白桦陈云霞丁岚李晶瑞马会娟
Owner CHINESE ACAD OF INSPECTION & QUARANTINE