Patch for treating oral ulcer

A technique for oral ulcers and patches, which is applied in the field of patches for the treatment of oral ulcers, to achieve the effects of simple drug components, pain relief, and no side effects

Inactive Publication Date: 2013-04-24
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many medicines used clinically for oral ulcers, including octahedral montmorillonite powder, aspirin gargle, lidocaine, watermelon cream, etc., but so far, there is no specific drug for recurrent oral ulcers , and the development of new drugs has never been interrupted

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Raw material weight ratio is:

[0013] Neomycin sulfate 1×10 6 IU; clotrimazole 1g; tetracaine hydrochloride 0.5g; betamethasone 4mg; borneol 5g; mannitol 5g; carboxymethylcellulose sodium 5g; ethanol 16.7mL;

[0014] The above-mentioned drug patch is prepared by the following steps: (1) Weigh each raw material according to the above-mentioned components and raw materials; (2) Swell carboxymethylcellulose sodium with 3 mL of hot purified water in advance, and then add 2 mL of purified water to grind it into a gel (3) Grind mannitol finely, add neomycin sulfate and clotrimazole to grind evenly, and then add 2 mL of purified water to grind into a paste; (4) Dissolve tetracaine hydrochloride in 2 mL of hot purified water to obtain tetracaine hydrochloride Caine solution, betamethasone and borneol were dissolved in 8 mL of ethanol to obtain an ethanol solution of betamethasone and borneol. (5) Add the paste obtained in step (3) to the glue obtained in step (2), grind Then...

Embodiment 2

[0016] Raw material weight ratio is:

[0017] Neomycin sulfate 0.5×10 6 IU; clotrimazole 0.5g; tetracaine hydrochloride 0.1g; betamethasone 1mg; borneol 2g; mannitol 2g; carboxymethylcellulose sodium 2g; ethanol 10mL;

[0018] The above drug patch is prepared by the following steps: (1) Weigh each API according to the above components and raw materials; (2) Swell carboxymethylcellulose sodium with 2 mL of hot purified water in advance, and then add 3 mL of purified water to grind it into a gel (3) Grind mannitol finely, add neomycin sulfate and clotrimazole to grind evenly, and then add 2 mL of purified water to grind into a paste; (4) Dissolve tetracaine hydrochloride in 2 mL of hot purified water to obtain tetracaine hydrochloride Caine solution, betamethasone, and borneol were added to 5 mL of ethanol to dissolve to obtain an ethanol solution of betamethasone and borneol. (5) Add the paste obtained in step (3) to the glue obtained in step (2), and grind Then add the tetra...

Embodiment 3

[0020] Raw material weight ratio is:

[0021] Neomycin sulfate 2×10 6 IU; clotrimazole 2g; tetracaine hydrochloride 1g; betamethasone 8mg; borneol 10g; mannitol 10g; carboxymethylcellulose sodium 10g; ethanol 20mL;

[0022] The above-mentioned drug patch is prepared by the following steps: (1) Weigh each raw material according to the above-mentioned components and raw materials; (2) Swell carboxymethylcellulose sodium with 6 mL hot purified water in advance, and then add 4 mL purified water to grind it into a gel (3) Grind mannitol finely, add neomycin sulfate and clotrimazole to grind evenly, and add 4 mL of purified water to grind into a paste; (4) Dissolve tetracaine hydrochloride in 4 mL of hot purified water to obtain tetracaine hydrochloride Caine solution, betamethasone, and borneol were dissolved in 12 mL of ethanol to obtain an ethanol solution of betamethasone and borneol. (5) Add the paste obtained in step (3) to the mucilage obtained in step (2), and grind Then a...

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PUM

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Abstract

The invention discloses a patch for treating oral ulcer. Every 625 patches are prepared from the following raw materials: 0.5*10<6> to 2*10<6>IU of neomycin sulfate, 0.5 to 2g of clotrimazole, 0.1 to 1g of tetracaine hydrochloride, 1 to 8mg of betamethasone, 2 to 10g of borneol, 2 to 10g of mannitol, 2 to 10g of sodium carboxymethylcellulose, 10 to 20mL of ethanol, 0.05 to 2mL of glycerol and 10 to 20mL of purified water. The medicine is simple in component and low in cost, has an obvious curative effect on patients suffering from recurrent oral ulcer and does not have any toxic or side effects.

Description

technical field [0001] The invention relates to a medicine for treating oral ulcer, in particular to a patch for treating oral ulcer. Background technique [0002] Oral ulcers are commonly known as "oral ulcers", which are medically called oral mucosal ulcers. They are superficial ulcers that occur on the oral mucosa, ranging in size from rice grains to soybeans, round or oval, and mostly occur on the tip of the tongue in the oral cavity Mucous membranes such as the edge, lips and cheeks, soft palate or bared teeth are the most common type of oral diseases. After a patient suffers from an oral ulcer, an ulcer wound will form on the oral mucosa. The surrounding area of ​​the ulcer is red and swollen, and the surface is grayish or yellowish, accompanied by concave surface of the ulcer and congestion around the ulcer, which can cause pain and depression for the patient , thereby affecting normal diet and life. [0003] At present, the cause of oral ulcers is not very clear, i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7036A61K31/573A61K31/4174A61K31/245A61K9/70A61P1/02
Inventor 张幸国赵青威洪东升张相宜
Owner ZHEJIANG UNIV
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