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Propolis ethanol extract for alleviating hangover and preparation method thereof, and application of propolis ethanol extract in producing buccal tablets

A technology of ethanol extraction and buccal tablets, which is applied in the direction of medical preparations containing active ingredients, medical raw materials derived from arthropods, drug combinations, etc., can solve problems such as impracticability, and achieve reduced oxidation failure, easy extraction, and fast speed Effect

Active Publication Date: 2013-04-24
周斌
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AI Technical Summary

Problems solved by technology

When people drink a lot of alcohol, they also take a lot of food, especially high-oil and high-fat food, which makes the stomach full, and it usually takes about 2 hours to empty the stomach content. If you take anti-alcohol drugs at the same time, Due to the large difference between the dose and the stomach content, it is difficult to exert its effect and fail. However, if a large dose of anti-alcohol medicine is used, it will be limited by the stomach capacity and cannot be implemented. Therefore, the anti-alcohol medicine used after meals must be Processed in a gastric insoluble form, which is the main reason why we developed buccal tablets

Method used

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  • Propolis ethanol extract for alleviating hangover and preparation method thereof, and application of propolis ethanol extract in producing buccal tablets
  • Propolis ethanol extract for alleviating hangover and preparation method thereof, and application of propolis ethanol extract in producing buccal tablets
  • Propolis ethanol extract for alleviating hangover and preparation method thereof, and application of propolis ethanol extract in producing buccal tablets

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Embodiment Construction

[0050] 1. Preparation of biologically active dry matter with a molecular weight less than 5000D and a solid content greater than 90%:

[0051] 1. Put the propolis in an ambient temperature of -18°C and freeze for 20-40 hours and then crush it.

[0052] 2. Mix edible alcohol with a volume concentration of 50%~90% and crushed propolis at a weight ratio of 1~10:1 under normal temperature and pressure, and treat it for 10~40 at a temperature of 10~40℃ before low-frequency ultrasound. Minutes, then airtightly soak for 1 to 4 days at an ambient temperature of 10-40°C.

[0053] 3. Take the soaked mixture and centrifuge at 8000-16000 rpm for 10-15 minutes to remove solid impurities, and take the supernatant of the propolis dissolved in ethanol.

[0054] 4. The supernatant is separated by ultrafiltration with 5000D molecular sieve at an ambient temperature of 1 to 5°C to obtain an ethanol extract of propolis with a molecular weight of less than 5000D.

[0055] 5. Place the above-mentioned propo...

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Abstract

The invention relates to a propolis ethanol extract for alleviating a hangover and a preparation method thereof, and application of the propolis ethanol extract in producing buccal tablets, belonging to the technical field of techniques for extracting effective substances from propolis. The method comprises the following steps: freezing propolis, pulverizing, removing impurities, soaking at normal temperature under normal pressure, carrying out ultrasonic extraction, carrying out refrigerated centrifugation to remove solid impurities, taking the ethanol solution, and finally, separating out the propolis ethanol extract with the molecular weight of lower than 5000D at the ambient temperature of 1-5 DEG C; and distilling the ethanol to recover a bioactive dried substance with the solid content of higher than 90% and the molecular weight of lower than 5000D, and mixing the bioactive dried substance with royal jelly freeze-dried powder, isomalt, magnesium stearate, menthol and the like to obtain the buccal tablets for alleviating a hangover. The invention has the advantages of obvious hangover alleviating effect, no side effect and low cost, and is simple and easy to implement.

Description

Technical field [0001] The invention relates to the technical field of extracting active substances from animals and plants and their secretions, especially propolis. Background technique [0002] my country is the earliest country in the world to make wine. Wine culture has penetrated into many social cultures and has long become an indispensable part of daily life. With the improvement of people’s material, cultural, and living standards, excessive drinking has become a worldwide social public health problem. The incidence of alcoholic hepatitis has also been increasing, and it has become the first after viral hepatitis in my country. The second major liver disease: Due to cultural, historical or personal preferences, the complete elimination of bad drinking habits still requires long-term efforts by the entire society. [0003] At present, there are more and more various kinds of entertainment. The incidence of various liver diseases caused by alcoholism is increasing year by ye...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61P39/02A61K35/644
Inventor 周斌季福标叶满红季剑
Owner 周斌
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