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Method for extracting borneol camphor tree leaf crude extract and applied response surface methodology

A technology of borneol camphor and crude extract, which is applied in the direction of solid solvent extraction, etc., can solve the problems of low extraction yield, large-scale production, long distillation time, complicated equipment, etc., achieve high use value, simple method steps, and reduce energy consumption. consumption effect

Inactive Publication Date: 2013-05-08
浙江桐庐百草园中药材开发有限公司
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The method of extracting borneol from borneol camphor leaves is generally steam distillation, which is not conducive to large-scale production due to long distillation time, high temperature, large liquid-to-material ratio, complicated equipment, and low extraction yield.

Method used

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  • Method for extracting borneol camphor tree leaf crude extract and applied response surface methodology
  • Method for extracting borneol camphor tree leaf crude extract and applied response surface methodology
  • Method for extracting borneol camphor tree leaf crude extract and applied response surface methodology

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Effect test

Embodiment 1

[0059] Embodiment 1, a kind of borneol camphor leaf crude extract extraction method comprises the steps:

[0060] Dry the leaves of borneol camphor to a moisture content of ≤8% (weight content), crush them, and pass through a 60-mesh sieve; mix 0.5g of the powdered borneol leaves with 17.5ml of petroleum ether (boiling point 60-90°C) (ie , solid-liquid ratio 1:35), extracted at 48°C for 2 hours to obtain an extract.

[0061] Recovering the petroleum ether in the extract is as follows: the extract is placed in a flask, and rotated to evaporate at 35° C. and 100 rpm until no petroleum ether is evaporated; 0.03551 g of crude extract of borneol camphor leaves is obtained. The recovery rate of the crude extract of borneol camphor leaves was calculated to be 7.102%.

[0062] The composition of the extracted borneol camphor leaf crude extract is analyzed as follows:

[0063] 1. Gas chromatography-mass spectrometry test conditions

[0064] Chromatographic column: TR-5MS (30m×0.25mm...

Embodiment 2

[0074] Embodiment 2, the influence of extraction time change on the crude extract yield of borneol camphor leaves

[0075] Under the condition that the extraction temperature is set at 40°C and the liquid-to-material ratio is 30:1, the extraction time is set at 5 changing values ​​of 1-5 hours; the rest are the same as in Example 1. The result is as figure 2 shown.

[0076] When the extraction time was set to 2 hours, the yield of the crude extract of borneol camphor leaves was 6.912%. With the increase of time, the yield of the crude extract of borneol camphor leaves remained in a relatively stable state.

Embodiment 3

[0077] Embodiment 3, the influence of extraction temperature change on the crude extract yield of borneol camphor leaves:

[0078] Under the condition that the extraction time is set to 2 hours and the liquid-to-material ratio is 30:1, the extraction temperature is set to five variable values ​​of 20-60° C.; the rest are the same as in Example 1. The result is as image 3 shown.

[0079] When the extraction temperature was set at 40°C, the yield of the crude extract of borneol camphor leaves was 6.943%. With the increase of temperature, the yield of the crude extract of borneol camphor leaves remained in a relatively stable state.

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Abstract

The invention discloses a method for extracting a borneol camphor tree leaf crude extract. The method comprises the following steps of: mixing borneol camphor tree leaves and petroleum ether according to a material to liquid ratio of the petroleum ether to the borneol camphor tree leaves of 34-36 ml / g, and extracting at the temperature of 48-49 DEG C for 2 to 2.1 hours; and evaporating the obtained extract as the petroleum ether serving as a solvent, thus obtaining the borneol camphor tree leaf crude extract. The invention also provides a method for optimizing the borneol camphor tree leaf crude extract extraction method by response surface methodology. The following three variables are provided, namely the liquid to material ratio of the borneol camphor tree leaves to the petroleum ether, the extraction temperature and the extraction time; and optimization is executed according to Box-Behnken design by using design expert software. By the extraction method, the extraction rate of ice sheets can be increased, and consumption of solvents and resources is reduced, and production and emission of pollutants during production are reduced.

Description

technical field [0001] The invention relates to the extraction, component analysis and condition optimization of the crude extract of borneol camphor leaves, in particular to a method for optimizing the extraction conditions of the crude extract of borneol camphor leaves by using the response surface method. Background technique [0002] Borneol, also known as sliced ​​brain, orange slice, dipterocarp, is the crystallization obtained by extracting the resin and volatile oil processing products of dipterocarp plant dipterocarp, which is almost pure d-borneol. Its qi is fragrant, bitter, pungent and cool. It can be used to clear all orifices, dissipate stagnant fire, reduce swelling and relieve pain, reduce heat and detoxify, remove nebula and improve eyesight, and be used for conjunctival congestion, swelling and pain, sore throat, mouth sores, and sores. Ulcer swelling and pain, ulceration and so on. The natural borneol produced in our country is mainly extracted from the b...

Claims

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Application Information

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IPC IPC(8): B01D11/02
Inventor 沈慧珍陈绍瑗俞玉水
Owner 浙江桐庐百草园中药材开发有限公司
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