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Method for measuring benzo [a] pyrene content in cigarette filter

A technology of cigarette filter and determination method, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of limited application and poor ionization effect, and achieve the effects of shortening time, easy operation, and improving selectivity and sensitivity

Active Publication Date: 2014-12-17
CHINA NAT TOBACCO QUALITY SUPERVISION & TEST CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Since the ion sources prepared by LCMS / MS are generally electrospray ionization and atmospheric pressure chemical ionization ion sources, these ion sources have good ionization effects on macromolecular organic compounds, but poor ionization effects on polycyclic aromatic hydrocarbons, so the limitation its application in this field

Method used

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  • Method for measuring benzo [a] pyrene content in cigarette filter
  • Method for measuring benzo [a] pyrene content in cigarette filter
  • Method for measuring benzo [a] pyrene content in cigarette filter

Examples

Experimental program
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Effect test

Embodiment 1

[0030] 1. Instruments and reagents: benzo[a]pyrene standard (purity ≥98%), deuterated internal standard benzo[a]pyrene-d12 (benzo[a]pyrene-d12, purity ≥98%), purchased from From Supelco Company of the United States; acetonitrile (TEDIAcompany Inc., Ohio, USA), and all solvents were chromatographically pure.

[0031] Agilent 1200 high-resolution liquid chromatography (autosampler G1367D, binary solvent pump G1312B, column oven G1316B) (Agilent Technologies, PaloAlto, CA); API5500 triple quadrupole tandem mass spectrometry system (Applied Biosystems, Foster City, CA), Equipped with an atmospheric pressure photoionization ion source (APPI); Hitachi L-2130 pump (Hitachi High-Tech Co., Ltd., Japan); data acquisition and processing were implemented on Analyst1.5.1 software (Applied Biosystems).

[0032] 2. Sample treatment: Take a filter tip, peel off the wrapping paper and glue, put it into a 25mL Erlenmeyer flask, add 1μg / mL deuterated benzo[a]pyrene internal standard 200μL, then ...

Embodiment 2

[0035] Embodiment 2: Test method is as described in embodiment 1. Take 20 filter tips that have been smoked, and measure the content of benzo[a]pyrene in the filter tips to be 8.93ng / cigarette. The experimental results are shown in Table 2.

[0036] Table 2 Content levels of benzo[a]pyrene in cigarette filters of different brands smoked by smokers (ng / cigarette)

[0037]

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Abstract

The invention discloses a method for measuring benzo [a] pyrene content in a cigarette filter. The method comprises the following steps of: collecting a sample, pretreating the sample, preparing a standard working solution, measuring and analyzing by a liquid chromatography-tandem mass spectrometer (LC-MS / MS), and performing ionization on the sample by using an atmospheric photo ionization ion source. By the method, the benzo [a] pyrene content in the cigarette filter can be quickly and accurately detected; a measured result is accurate; and the interference factors are few.

Description

technical field [0001] The invention belongs to the technical field of physical and chemical inspection of cigarette filter samples, mainly relates to the technical field of determination of polycyclic aromatic hydrocarbons in cigarette filter samples, and specifically relates to a liquid chromatography-photoionization-tandem mass spectrometer (LC-APPI-MS) / MS) for the determination of benzo[a]pyrene content in cigarette filters. Background technique [0002] Since J. Cook first isolated benzo[a]pyrene from coal tar and induced skin cancer in mice in 1933, benzo[a]pyrene, as a confirmed human carcinogen, has attracted widespread attention from scientific researchers. Tumor epidemiological surveys and animal experiments have found that benzo[a]pyrene has strong carcinogenicity, which is closely related to the occurrence of tumors, especially highly related to the occurrence of human lung cancer. Benzo[a]pyrene is also present in cigarette smoke and smoked cigarette filters, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/88
Inventor 侯宏卫胡清源张小涛熊巍陈欢刘彤韩书磊姜兴益李中皓边照阳张洪非庞永强唐纲岭
Owner CHINA NAT TOBACCO QUALITY SUPERVISION & TEST CENT
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