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Salvianolic acid A dropping pill and application thereof to medicine preparation

A kind of technology of salvianolic acid and dripping pills, applied in the field of salvianolic acid A dripping pills and preparation of medicines

Active Publication Date: 2013-06-12
JIANGZI QINGFENG PHARMACEUTICALS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is still a big gap between this and the requirements of actual industrialization

Method used

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  • Salvianolic acid A dropping pill and application thereof to medicine preparation
  • Salvianolic acid A dropping pill and application thereof to medicine preparation
  • Salvianolic acid A dropping pill and application thereof to medicine preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0105] Take Danshen medicinal material, crush it into 4-mesh granules, add 7 times the amount of 92°C water each time, warm soak and extract 3 times, and stir at a speed of 25 rpm, warm soak and extract for 3 hours each time; the extract is concentrated under reduced pressure to relative Density 1.0-1.30 (60°C), add ethanol to make the alcohol content 70%, let it stand, filter, and recover ethanol from the filtrate under reduced pressure and concentrate until there is no alcohol smell; add water to dilute to 20mg of salvianolic acid B per 1ml, for aqueous solution 10% sodium hydroxide to adjust pH to 5.5, add 0.5% ZnCl 2 As a catalyst, heat and transform at 120°C for 4 hours, adjust the pH value of the transformation liquid to 2.5 with 20% phosphoric acid, centrifuge, concentrate the supernatant under reduced pressure to contain 3 mg of salvianolic acid A per 1 ml, and perform HPD-100 macroporous resin column chromatography For separation, the ratio of the loading amount of sa...

Embodiment 2

[0108] Take the Danshen medicinal material, crush it into particles with a diameter of about 2mm, add 9 times the amount of 95°C water each time, warm soak and extract 3 times, and stir at a speed of 30 rpm, and warm soak and extract for 2.5 hours each time; the extract is concentrated under reduced pressure to Relative density 1.0~1.30 (60°C), add ethanol to make the alcohol content 70%, let it stand, filter, the filtrate recovers ethanol under reduced pressure and concentrates until there is no alcohol smell; add water to dilute to contain salvianolic acid B15mg per 1ml, aqueous solution Adjust pH to 4.5 with 10% NaOH, add 0.5% ZnCl 2As a catalyst, heat conversion at 120°C (0.01MPa~0.20MPa pressure) for 4 hours, adjust the pH value of the conversion liquid to 2.8 with 15% phosphoric acid, centrifuge, concentrate the supernatant under reduced pressure to contain 5 mg of salvianolic acid A per 1 ml, and pass through HPD -100 macroporous resin column chromatography separation, ...

Embodiment 3

[0111] Take Salvia miltiorrhiza, crush it into particles with a diameter of about 2mm, add 7 times the amount of 90°C water each time, warm soak and extract 3 times, and stir at a speed of 25 rpm, and warm soak and extract for 3 hours each time; the extract is concentrated under reduced pressure to Relative density 1.0~1.30 (60°C), add ethanol to make the alcohol content 70%, let it stand, filter, the filtrate recovers ethanol under reduced pressure and concentrates until there is no alcohol smell; add water to dilute to contain salvianolic acid B20mg per 1ml, aqueous solution Adjust pH to 5.5 with 10% NaOH, add 0.5% ZnCl 2 As a catalyst, heat conversion at 120°C (0.01MPa~0.20MPa pressure) for 4 hours, adjust the pH value of the conversion liquid to 2.5 with 20% phosphoric acid, centrifuge, concentrate the supernatant under reduced pressure to contain 3 mg of salvianolic acid A per 1 ml, and pass through HPD -100 macroporous resin column chromatography separation, the ratio of...

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Abstract

The invention relates to application of a salvianolic acid A dropping pill to preparation of medicine for preventing and / or treating ischemic cerebrovascular disease. The salvianolic acid A dropping pill contains by weight 5%-60% of a salvianolic acid A composition and 95%-40% of a substrate. The salvianolic acid A composition comprises salvianolic acid A more than 93% and less than 100%, and other 4 ingredients including 0.1%-2% of alkannic acid, 0.1%-2% of rosmarinic acid, 0.1%-2% of salvianolic acid B and 0.1%-2% of salvianolic acid C. The substrate is one or more selected from PEG 4000, PEG 6000, PEG 8000, gelatin, stearic acid, glycerol monostearate, insect wax and hydrogenated vegetable oil.

Description

technical field [0001] The invention relates to a salvianolic acid A drop pill and its use in preparing medicines. technical background [0002] Ischemic heart disease (IHD) is myocardial damage resulting from an imbalance between coronary blood flow and myocardial demand caused by alterations in the coronary circulation, most commonly due to coronary atherosclerosis, coronary thrombosis, and coronary artery spasm , accounting for about 90% of ischemic heart disease. What they have in common is that myocardial ischemia, hypoxia, myocardial energy metabolism is abnormal, and cannot support the normal work of the heart due to the contradiction between oxygen supply and demand caused by insufficient myocardial blood supply. Myocardial infarction is life-threatening. According to the location, scope and severity of coronary artery disease, and the degree of myocardial ischemia, it can be divided into five clinical categories: asymptomatic myocardial ischemia, angina pectoris, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/216A61K31/343A61K36/537C07C69/732A61P7/02A61P9/10
Inventor 吕武清欧阳婷张功俊王振罗恒真魏宇清
Owner JIANGZI QINGFENG PHARMACEUTICALS INC
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