Unlock instant, AI-driven research and patent intelligence for your innovation.

Mannose ester enteric capsule and preparation method thereof

A technology of enteric-coated capsules and glycose esters, applied in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve problems such as low bioavailability, monotonous dosage forms, absorption, and unsatisfactory therapeutic effects. Achieve the effect of improving bioavailability, stable quality, and ideal enteric effect

Active Publication Date: 2013-06-12
CP PHARMA QINGDAO CO LTD
View PDF1 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Glycosyl ester raw materials and its tablets were approved by the State Drug Administration in 1994, and have been produced by Qingdao No. 3 Pharmaceutical Factory. At present, the Glycosyl esters on the market only have one dosage form, which is monotonous and common, and is subject to disintegration. , drug release and other factors, the absorption and therapeutic effect are not ideal, and the bioavailability is not high

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Mannose ester enteric capsule and preparation method thereof
  • Mannose ester enteric capsule and preparation method thereof
  • Mannose ester enteric capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0022] A preparation method of glycose ester enteric-coated capsules, comprising the following steps:

[0023] (1) Mix the glyceryl ester and the filler evenly, and use 85% ethanol as a binder to make 20-30 mesh glyceric ester pellets for later use;

[0024] (2) Dissolve enteric-coated material, plasticizer, anti-sticking agent with 80% ethanol, make enteric-coated liquid;

[0025] (3) Evenly spray the prepared enteric-coating solution on the surface of the glycose ester pellets prepared in step (1), and dry to obtain the glycose ester enteric-coated pellets.

[0026] (4) Fill the glycinose ester enteric-coated pellets into the capsule shell to obtain the product.

Embodiment 1～6

[0027] The preparation of embodiment 1~6 glycose ester enteric-coated capsule

[0028] According to the raw and auxiliary materials in the following table, according to the above-mentioned preparation method, the glycose ester enteric-coated capsules of six embodiments were prepared. Among them, " / " means not used.

[0029]

[0030] Test Example 1 Determination of Dissolution of Glycosyl Ester Enteric-Coated Capsules Gained in Examples 1-6

[0031] According to the dissolution test method (the second method on page 60 of the second appendix of the Chinese Pharmacopoeia in 2000), an appropriate amount of glycose ester enteric-coated pellets was precisely weighed, and the dissolution media were: artificial gastric juice at pH 1.2 and artificial intestinal juice at pH 6.8, Using artificial gastric juice and artificial intestinal juice as solvents, the dissolution rate was determined. The results are shown in Table 1 and Table 2.

[0032] Table 1 Example 1-6 Glycosyl ester e...

Embodiment 7～13

[0038] Preparation of Example 7-13 Glycerol Ester Enteric-Coated Capsules

[0039] According to the raw and auxiliary materials in the following table, according to the above-mentioned preparation method, glycose ester enteric-coated capsules were respectively prepared in each embodiment. The weight ratio of cellulose acetate phthalate to cellulose acetate succinate in Example 7 is 4:1, and the weight ratio of cellulose acetate phthalate to cellulose acetate succinate in Example 8 is 3:1. The weight ratio of cellulose acetate phthalate to cellulose acetate succinate in Example 9 is 2:1, and the weight ratio of cellulose acetate phthalate to cellulose acetate succinate in Example 10 is 1:1. The weight ratio of cellulose acetate phthalate to cellulose acetate succinate in Example 11 is 1:2, and the weight ratio of cellulose acetate phthalate to cellulose acetate succinate in Example 12 is 1:3. The weight ratio of cellulose acetate phthalate to cellulose acetate succinate in Exa...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a mannose ester enteric capsule and a preparation method of the mannose ester enteric capsule. The mannose ester enteric capsule is prepared by placing mannose ester enteric micropelets into a capsule shell, wherein the mannose ester enteric micropelets are composed of mannose ester micropelets and enteric coatings, wherein the enteric coatings are wrapped outside the mannose ester micropelets; the mannose ester micropelets consist of mannose esters and fillers; the enteric coatings are composed of enteric materials, plasticizers and antisticking agents; and when in preparation, the enteric coatings are wrapped outside the mannose ester micropelets so as to obtain the mannose ester enteric capsule. The mannose ester enteric capsule is convenient to take and ideal in enteric effect, and can improve the bioavailability; in addition, the preparation process is simple, the obtained product is stable in quality, and massive production and application can be realized.

Description

technical field [0001] The invention relates to the technical field of western medicine preparations, in particular to a glycose ester enteric-coated capsule, and also relates to a preparation method of the enteric-coated capsule. Background technique [0002] Glycosyl Glycerate (PGMS), a new type of heparan-like marine drug, is the sodium salt of propyl mannuronate sulfate obtained by hydrolysis and esterification of sodium alginate diester. Glyceride contains a large number of acidic groups and is a linear polyanionic acidic polysaccharide. The monosaccharide in the structure is only mannuronic acid. It has antithrombotic, anticoagulant, antiarteriosclerosis, enhanced fibrinolysis, and blood lipid regulation. Glycosyl ester raw materials and its tablets were approved by the State Drug Administration in 1994, and have been produced by Qingdao No. 3 Pharmaceutical Factory. At present, the Glycosyl esters on the market only have one dosage form, which is monotonous and common...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/48A61K31/715A61K47/38A61P7/02A61P9/10A61P3/00
Inventor 王明刚任莉陈阳生
Owner CP PHARMA QINGDAO CO LTD