Pharmaceutical composition for treating tinea pedis and preparation method thereof

A composition and drug technology, applied in the field of medicine, can solve problems such as side effects, sharp itching of feet, and low satisfaction, and achieve the effect of less side effects and less adverse reactions

Inactive Publication Date: 2013-06-12
邵武市美菰林卫生用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although the above-mentioned fungal antibiotics have the effect of quickly killing pathogenic fungi, they have some adverse reactions such as side effects, and sharp itching of the foot skin is one of the main symptoms of tinea pedis. During the process, only the fungus lurking in the feet is killed. Before the skin of the feet is completely killed, the feet will also have symptoms of severe itching, which makes patients not very satisfied with the cream containing only antifungal antibiotics. high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] 1) The oil phase component raw materials of the following parts by weight are weighed and thrown into the oil phase container to obtain the oil phase mixture A: 8.0 kg of glyceryl monostearate and PEG-100 stearate, 5.0 kg of palm stearyl alcohol, 8.0 Kg of white oil, 0.6 kg of Pan 60, 3.0 kg of stearic acid, 2.0 kg of Melaleuca alternifolia oil, 1.0 kg of glyceryl monostearate, 0.2 kg of ethyl paraben, 0.1 kg of dibutyl hydroxytoluene;

[0040] Weigh the following water phase component raw materials into the water phase container to obtain the water phase mixture B: 2.5 kg of glycerin, 4.0 kg of potassium cetyl phosphate, 43.5 kg of purified water, 0.0004 kg of sodium citrate, 0.0001 kg of citric acid monohydrate;

[0041] Weigh the following parts by weight of the pharmaceutically active component raw materials and throw them into the pharmaceutically active component container to obtain the pharmaceutically active component mixture C: 9.0 kg of propylene glycol, 1.0 k...

Embodiment 2

[0047] 1) Weigh the following oil phase component raw materials into the oil phase container to obtain oil phase mixture A: 5.0 kg of glyceryl monostearate and PEG-100 stearate, 3.0 kg of palm stearyl alcohol, 5.0 Kg of white oil, 0.5 kg of Pan 60, 2.0 kg of stearic acid, 1.0 kg of Melaleuca alternifolia oil, 1.0 kg of glyceryl monostearate, 0.1 kg of ethyl paraben, 0.1 kg of dibutyl hydroxytoluene;

[0048] Weigh the following water phase component raw materials into the water phase container to obtain the water phase mixture B: 1.0 kg of glycerin, 2.0 kg of potassium cetyl phosphate, 45.0 kg of purified water, 0.0004 kg of sodium citrate, 0.0001 kg citric acid monohydrate;

[0049] Weigh the following parts by weight of the pharmaceutically active component raw materials and throw them into the pharmaceutically active component container to obtain the pharmaceutically active component mixture C: 5.0 kg of propylene glycol, 1.0 kg of menthol, 1.0 kg of camphor, 1.0 kg of born...

Embodiment 3

[0055] 1) Weigh the following oil phase component raw materials into the oil phase container to obtain oil phase mixture A: 10.0 kg of glyceryl monostearate and PEG-100 stearate, 10.0 kg of palm stearyl alcohol, 10.0 Kg of white oil, 1.0 kg of Pan 60, 5.0 kg of stearic acid, 4.0 kg of Melaleuca alternifolia oil, 3.0 kg of glyceryl monostearate, 0.2 kg of ethyl paraben, 0.2 kg of dibutyl hydroxytoluene;

[0056] Weigh the following water phase component raw materials into the water phase container to obtain the water phase mixture B: 5.0 kg of glycerin, 6.0 kg of potassium cetyl phosphate, 55.0 kg of purified water, 0.0004 kg of sodium citrate, 0.0001 kg of citric acid monohydrate;

[0057] Weigh the following parts by weight of the pharmaceutically active component raw materials and throw them into the pharmaceutically active component container to obtain the pharmaceutically active component mixture C: 10.0 kg of propylene glycol, 2.0 kg of menthol, 2.0 kg of camphor, 2.0 kg ...

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PUM

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Abstract

The invention belongs to the field of medicine, and particularly relates to a pharmaceutical composition for treating tinea pedis and a preparation method thereof. The pharmaceutical composition has the functions of killing preclinical dermatophytes of feet and immediately improving the symptoms of foot pruritus after the pharmaceutical composition added with an anti-pruritus component and a local anesthetic component is used. After use of the According to the pharmaceutical composition, severe pruritus of skin of feet can be relived quickly. According to the technical scheme, the pharmaceutical composition for treating tinea pedis comprises the following raw materials: white oil, emulsifier 60, stearic acid, melaleuca alternifolia, silicone emulsion, ethyparaben, glycerol, purified water and sodium citrate-citric acid pH value buffer system. The pharmaceutical composition has the beneficial effect that the symptom of foot pruritus can be improved immediately after the pharmaceutical composition added with the anti-pruritus component and the local anesthetic component is used.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a pharmaceutical composition for treating tinea pedis and a preparation method thereof. Background technique [0002] Tinea pedis is also called athlete's foot, Hong Kong's foot, refers to the disease that occurs in the skin fungus infection of plantar region, between toes and sole. Tinea pedis is a kind of contagious disease, through the infection of shoes, socks, bath towel and foot skin contact. At present, the main way to treat tinea pedis is to use antifungal treatment to treat the infected foot, and kill the pathogenic fungi lurking in the dermis of the foot skin, such as epidermophyton, trichophyton, rubrum, etc. For example, the 2% miconazole nitrate cream of Xi'an Janssen Pharmaceutical Co., Ltd. is applied to the skin part suffering from tinea pedis, and after 7 days to 2 weeks of continuous use, the pathogenic fungus lurking in the foot skin can be killed. [0003] ...

Claims

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Application Information

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IPC IPC(8): A61K31/167A61K31/137A61P17/00A61P31/10A61P17/04
Inventor 吴燕斌肖永堂
Owner 邵武市美菰林卫生用品有限公司
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