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Dimemorfan phosphate tablet composite and preparation method thereof

A technology for dimethylphene phosphate and composition, which is applied in the field of dimethylphene phosphate tablet composition and preparation thereof, and achieves the effects of simple preparation process, easy disintegration, and increased hardness

Active Publication Date: 2013-06-26
SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no such drug in China at present, and the development of domestically produced dimethylorphinyl phosphate will meet clinical needs and will have good social and economic benefits

Method used

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  • Dimemorfan phosphate tablet composite and preparation method thereof

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Effect test

Embodiment 1

[0028] The present embodiment provides a composition of dimethylorphan phosphate tablet, and the active ingredient of the medicine includes the following components in parts by weight:

[0029] 10 mg of Dimethyrphane Phosphate, 90 mg of Microcrystalline Cellulose, 12 mg of Calcium Bicarbonate, 8 mg of Sodium Carboxymethyl Starch, 1 mg of Magnesium Stearate, 2.5 mg of Gastric-soluble Film Coating Premix.

[0030] The preparation method of the dimethylorphin phosphate tablet composition of the present embodiment comprises the following steps:

[0031] Sieving: the above-mentioned raw and auxiliary materials are respectively passed through a 100-mesh sieve.

[0032] Mixing: Weigh the above-mentioned dimethylorphinyl phosphate, microcrystalline cellulose, sodium carboxymethyl starch and calcium bicarbonate in parts by mass, and mix them evenly.

[0033] Granulation: Use an appropriate amount of 60% ethanol solution as a wetting agent to make a soft material, granulate with a 24-m...

Embodiment 2

[0040] The present embodiment provides a composition of dimethylorphan phosphate tablet, and the active ingredient of the medicine includes the following components in parts by weight:

[0041] Dimethyrphane phosphate 10mg, microcrystalline cellulose 91mg, calcium bicarbonate 11mg, sodium carboxymethyl starch 7.5mg, magnesium stearate 1.25mg, gastric soluble film coating premix 1.9mg.

[0042] The preparation method of the dimethylorphin phosphate tablet composition of the present embodiment comprises the following steps:

[0043] Sieving: the above-mentioned raw and auxiliary materials are respectively passed through a 100-mesh sieve.

[0044] Mixing: Weigh the above-mentioned dimethylorphinyl phosphate, microcrystalline cellulose, sodium carboxymethyl starch and calcium bicarbonate in parts by mass, and mix them evenly.

[0045] Granulation: Use an appropriate amount of 60% ethanol solution as a wetting agent to make a soft material, granulate with a 24-mesh sieve, dry at 5...

Embodiment 3

[0052] The present embodiment provides a composition of dimethylorphan phosphate tablet, and the active ingredient of the medicine includes the following components in parts by weight:

[0053] Dimethyrphane phosphate 10mg, microcrystalline cellulose 87mg, calcium bicarbonate 12mg, sodium carboxymethyl starch 8.5mg, magnesium stearate 0.85mg, gastric soluble film coating premix 3mg.

[0054] The preparation method of the dimethylorphin phosphate tablet composition of the present embodiment comprises the following steps:

[0055] Screening: the above-mentioned raw and auxiliary materials are respectively passed through a 100-mesh sieve.

[0056] Mixing: Weigh the above-mentioned dimethylorphinyl phosphate, microcrystalline cellulose, sodium carboxymethyl starch and calcium bicarbonate in parts by mass, and mix them evenly.

[0057] Granulation: Use an appropriate amount of 60% ethanol solution as a wetting agent to make a soft material, granulate with a 24-mesh sieve, dry at 55°...

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Abstract

The invention relates to the field of pharmaceutical preparation, and specifically relates to a dimemorfan phosphate tablet composite and a preparation method thereof. The composite comprises the following active ingredients in percentage by weight: 8-8.2% of dimemorfan phosphate tablets, 72-73% of microcrystalline cellulose, 9-10% of calcium bicarbonate, 6-7% of sodium carboxymethyl starch, and 0.7-1% of magnesium stearate. The method for preparing a dimemorfan phosphate tablet composite provided by the embodiment of the invention comprises the steps of sieving, mixing, granulating, total mixing, pelleting and the like. A dimemorfan phosphate tablet disclosed by the embodiment of the invention has the advantages of low cost and good pharmaceutical effect, becomes one of the domestic low-cost and high-efficiency antibechic, and has an extremely good promotion value; and the preparation method of dimemorfan phosphate tablets provided by the embodiment of the invention has the advantages of simple preparation process and high production efficiency.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a composition of dimethylorphinyl phosphate tablets and a preparation method thereof. Background technique [0002] Cough is one of the most common complaints among outpatients in internal medicine and the leading reason for outpatient visits. Frequent coughing seriously affects the patient's work, sleep, and daily life, and some severe coughing can even cause complications such as pneumothorax, hemoptysis, urinary incontinence, and syncope. The complex defense reflex of coughing is usually elicited by irritation of the bronchi. Coughing is a normal way to clear the bronchi of liquid or solid foreign bodies, and a productive cough is an effective means of fighting respiratory infections. An ineffective dry cough requires antitussives to improve symptoms and help patients recover from underlying illnesses. Antitussives are generally used when the cough is unbearable or has interfered w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K9/20A61K31/485A61K47/38A61K47/36A61P11/14
Inventor 李明杰阮朝滨黄春燕王春艳
Owner SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
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