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Preparation method of blended functional surgical irrigating fluid

A surgical flushing solution and functional technology, applied in the field of medical materials, can solve the problems of exudation and bleeding without effect, and achieve the effects of no side effects, promotion of antibacterial effect, hemostasis and antibacterial effect

Active Publication Date: 2013-07-17
HRB CHURUN MEDICAL EQUIP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The flushing solution currently used clinically can only be used for physical flushing of the surgical site, and has no effect on exudation and bleeding

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] 1) Add activated carbon into water, heat and boil for 30 minutes, filter, and set aside;

[0015] 2) Weigh 4 g of sterile sodium carboxymethyl cellulose and 1 g of sterile sodium alginate respectively, place them in a stirring vessel with a circulation device, add 800 ml of purified water to swell under sterile conditions, raise the temperature to 60°C, Stir evenly to obtain a clear and transparent blend solution of sodium alginate and sodium carboxymethylcellulose, and wait for the solution to cool to room temperature;

[0016] 3) Take 1g of soluble lysozyme powder, add 9g of sodium chloride solution and stir, slowly pour into the above solution under the condition of stirring or ultrasonic vibration, mix and stir evenly, keep stirring at room temperature for 40-60 minutes to dissolve it, and then dissolve it with hydrochloric acid Adjust the pH to between 4.0-7.5;

[0017] 4) Add water to the full amount, measure the viscosity and osmotic pressure, and pass the stock...

Embodiment 2

[0024] In this example, the animal experiment of blending functional surgical flushing fluid to assist hemostasis is compared with traditional normal saline:

[0025] Get 20 healthy adult Kunming mice, body weight 20 ± 2g, half male and half male, randomly divided into 2 groups: (1) test group (this product with a concentration of 4‰); (2) control group (0.85% normal saline) , mouse intraperitoneal injection of 5% chloral hydrate, after anesthesia for 3-5 minutes, subtract 1cm of the tail of the mouse, when bleeding, the test group used absorbent cotton gauze with a concentration of 1.3%, and the control group used normal saline gauze. Add oppression. Simultaneously start timing, suck the blood from the wound with cotton wool every 10 seconds until the bleeding stops. Record the bleeding time (hemostasis time: the time until no more bleeding and bleeding). The hemostasis time of the test group is 50% shorter than that of the control group. The difference between the two group...

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Abstract

The invention relates to the technical field of medical materials, in particular to a preparation method of blended functional surgical irrigating fluid. The method includes: respectively taking 4% of sterile sodium carboxymethyl cellulose and 1% of sterile sodium alginate, disposing the two into a stirring container with a circulating device, adding purified water for swelling under the sterile condition, heating up, stirring well, obtaining a clear and transparent blended solution of the sodium alginate and the sodium carboxymethyl cellulose, and cooling the solution to normal temperature; and taking 1% of soluble lysozyme powder, adding 9% of sodium chloride solution into the powder and stirring, slowly pouring into the blended solution while stirring, mixing well, and using hydrochloric acid to adjust pH to 4.0-7.5. The preparation method of the blended functional surgical irrigating fluid has the advantages that the irrigating fluid prepared by the method is suitable for errhysis and exudation in surgery and trauma, can effectively stop bleeding and promote tissue healing, has an antibacterial action, and is complete in degradation, capable of being absorbed and utilized by bodies, free of side effect on the bodies, and safe in use.

Description

technical field [0001] The invention relates to the technical field of medical materials, in particular to a preparation method for blending functional surgical flushing fluid. Background technique [0002] Sodium carboxymethyl cellulose, sodium alginate, and lysozyme are absorbable polymer synthetic materials, which are non-toxic, good biocompatibility, degradability, and renewability. Sodium alginate and sodium carboxymethylcellulose have a certain hemostatic effect and promote wound repair, and they have been widely used in wound dressings in recent years. The hydrophilic groups of alginate and carboxymethyl cellulose absorb wound exudate, and can form a layer of hydrophilic gel film on the surface of the wound to provide a better healing environment for the wound and promote wound healing. Carboxymethyl cellulose has better hygroscopicity than seaweed fiber, but it is easy to lose stability. Lysozyme, also known as mureinase or N-acetyl murein hydrolase, is a salt-base...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/47A61K9/08A61P41/00A61P7/04A61P31/02A61P17/02A61K31/734A61K31/717
Inventor 张巍
Owner HRB CHURUN MEDICAL EQUIP
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