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Chlorhexidine gluconate composite disinfectant

A technology of chlorhexidine gluconate and gluconolactone, which is applied in the direction of disinfectants, antiviral agents, biocides, etc., can solve the safety hazards of patients or end users, and the pertinence is not strong, and the preparation accuracy cannot be obtained Guarantee and other issues to achieve the effect of avoiding cross-contamination and infection, ensuring safety and stability, and broadening antibacterial and bactericidal effects

Inactive Publication Date: 2013-07-24
江苏健裕健康医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The chlorhexidine gluconate disinfectant currently used in the market has a single variety, is not highly targeted, and has limited disinfection and sterilization effects, making it difficult to meet the current diversified and compound disinfection and sterilization requirements
At the same time, the preparation accuracy cannot be guaranteed, and the germs and microorganisms in the product cannot be effectively controlled
Possesses a significant safety hazard to patients or end users

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0027] A benzalkonium chloride disinfectant, which consists of chlorhexidine gluconate, coconut acid diethanolamide, lemon essence, gluconolactone, hydroxyethyl cellulose, isopropanol, laurylamine oxide, wool It is prepared from fat, tridecyl alcohol and water for injection. The weight percentage of each component is: chlorhexidine gluconate 4%, cocoic acid diethanolamide 0.1%, lemon flavor 0.02%, gluconolactone 0.01% , Hydroxyethylcellulose 0.01%, Isopropanol 1%, Laurylamine Oxide 0.1%, Lanolin 0.01%, Tridecyl Alcohol 0.01%, Water for Injection 94.74%.

[0028] The preparation steps of the present invention are as follows:

[0029] The first step is to prepare raw materials according to the ratio of each component, taking 100 kg as an example:

[0030] The weight of each component is as follows

[0031] component name

Component percentage ratio

weight

Chlorhexidine Gluconate

4%

4kg

Diethanol amine cocoate

0.1%

0.1kg

lem...

Embodiment approach 2

[0041] A chlorhexidine gluconate compound disinfectant, which is oxidized by chlorhexidine gluconate, coconut acid diethanolamide, lemon essence, gluconolactone, hydroxyethyl cellulose, isopropanol, and laurylamine lanolin, tridecyl alcohol and water for injection, the weight percentage of each component is: chlorhexidine gluconate 1%; cocoic acid diethanolamide 0.1%; lemon essence 0.01%; gluconic acid Lactone 0.01%; Hydroxyethylcellulose 0.01%; Isopropanol 1%; Laurylamine Oxide 0.1%; Lanolin 0.01%; Tridecyl Alcohol 0.01%.

Embodiment approach 3

[0043] A chlorhexidine gluconate compound disinfectant, which is oxidized by chlorhexidine gluconate, coconut acid diethanolamide, lemon essence, gluconolactone, hydroxyethyl cellulose, isopropanol, and laurylamine lanolin, tridecyl alcohol and water for injection, the weight percentage of each component is: 5% chlorhexidine gluconate; 10% coconut acid diethanolamide; 5% lemon essence; gluconic acid Lactone 5%; Hydroxyethyl Cellulose 5%; Isopropanol 30%; Laurylamine Oxide 10%; Lanolin 10%; Tridecyl Alcohol 5%.

[0044] The preparation method of embodiment two and embodiment three is the same as embodiment one, only the weight of each component and water for injection is different.

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PUM

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Abstract

The invention aims to provide a chlorhexidine gluconate composite disinfectant. The chlorhexidine gluconate composite disinfectant is prepared from chlorhexidine gluconate, coco fatty acid diethanol amide, lemon essence, delta-gluconolactone, hydroxyethyl cellulose, isopropanol, lauryl amine oxide, wool grease, tridecanol, and water for injection. The chlorhexidine gluconate composite disinfectant can perform comprehensive disinfection treatment on infection of skin, wound, trauma and burn before and after a surgery, can comprehensively disinfect the surgical instruments, has wide bacteriostatic and bactericidal effects and high effects, has a killing effect on all gram-positive bacterium, gram-negative bacterium, fungus, acid-fast bacteria, germs and viruses, is still effective in presence of serum and blood, causes no irritation to skin tissues, and is convenient and safe to use.

Description

【Technical field】 [0001] The invention relates to a medical disinfectant, in particular to a disinfectant used for skin disinfection before surgery, cleaning and disinfection of wounds, disinfection and storage of surgical instruments, and for doctors to wash their hands before and after surgery. 【Background technique】 [0002] Chlorhexidine gluconate is a disinfectant and preservative. Its antibacterial and bactericidal effect is broad and strong. It has a stronger antibacterial effect on Gram-positive bacteria than negative bacteria. It is stronger than quaternary ammonium cationic surfactants. Also effective, but not against acid fast bacteria, spores and viruses. [0003] The chlorhexidine gluconate disinfectant currently used in the market has a single variety, is not highly targeted, and has limited disinfection and sterilization effects, making it difficult to meet the current diversified and compound disinfection and sterilization requirements. At the same time, the...

Claims

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Application Information

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IPC IPC(8): A61K31/191A61P31/04A61P31/10A61P31/12A01N47/44A01P1/00A01P3/00A61K8/97A61Q19/10A61K31/155A61K31/14A01N33/12
Inventor 储小健许金平
Owner 江苏健裕健康医疗器械有限公司
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