Eye drop containing VEGF antagonist

An eye drop and antagonist technology, applied in the field of eye drops containing VEGF antagonist, can solve the problems of instability, limited effect, high cost and the like, and achieve the effects of saving production cost, accurate curative effect and extremely high content

Active Publication Date: 2013-07-24
CHENGDU KANGHONG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the concentration of the eye drops is relatively high. Due to the instability of biological agents, many patients receiving anti-vascular therapy on the ocular surface are unwilling to be hospitalized. High concentrations of biological agents are likely to cause inconvenience in storage and use. Ocular surface administration is a special route of administration. For pH, osmotic pressure and local irritation, bacteriostats and antibacterial agents cannot be added. The above problems make the drugs used for ocular surface anti-neovascular treatment expensive and have limited effect

Method used

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  • Eye drop containing VEGF antagonist
  • Eye drop containing VEGF antagonist
  • Eye drop containing VEGF antagonist

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Example 1, Conbercept Eye Drops Study on Corneal Neovascularization Induced by Alkali Burn

[0054] Drugs: Chlortetracycline Hydrochloride Eye Ointment, specification batch number: 2.0g / bottle, 411002, valid until December 2014, Chongqing Kerui Pharmaceutical Co., Ltd.; lidocaine hydrochloride injection, specification batch number: 5ml / bottle, 0.1g / bottle, Valid until April 2012, Tianjin Pharmaceutical Jiaozuo Co., Ltd.

[0055] Reagent: sodium hydroxide (NaOH), specification batch number: 500g / bottle, 20091223, Chengdu Kelong Chemical Reagent Factory.

[0056] Samples tested:

[0057] A, Conbercept eye drops (prepared according to Example 3) 10mg / ml, colorless transparent liquid, 1ml / bottle, batch number: FR1108001, stored at 2-8°C, added dropwise to the surface of the eye when used;

[0058] B, Conbercept eye drops (prepared according to Example 3) 9mg / ml, colorless transparent liquid, 1ml / bottle, batch number: FR1108002, stored at 2-8°C, added dropwise to the surfa...

Embodiment 2

[0073] Example 2 Effect of low-dose Conbercept eye drops on corneal NV growth caused by alkali burn

[0074] Drugs: Chlortetracycline Hydrochloride Eye Ointment, specification batch number: 2.0g / bottle, 411002, valid until December 2014, Chongqing Kerui Pharmaceutical Co., Ltd.; lidocaine hydrochloride injection, specification batch number: 5ml / bottle, 0.1g / bottle, Valid until April 2012, Tianjin Pharmaceutical Jiaozuo Co., Ltd.

[0075] Reagent: sodium hydroxide (NaOH), specification batch number: 500g / bottle, 20091223, Chengdu Kelong Chemical Reagent Factory.

[0076] Samples tested:

[0077] A, Conbercept Eye Drops (prepared according to Example 3) 0.5mg / ml, colorless transparent liquid, 800 μl / bottle, batch number: 20111001, stored at 2-8°C, added dropwise to the surface of the eye when used;

[0078] B, Conbercept eye drops (prepared according to Example 3) 0.1 mg / ml, colorless transparent liquid, 800 μl / bottle, batch number: 20111001, stored at 2-8°C, added dropwise to...

Embodiment 3

[0093] Embodiment 3, the preparation of Conbercept (FP3 fusion protein) eye drops

[0094] prescription:

[0095] FP3 fusion protein 10mg / ml, 9mg / ml, 5mg / ml, 1mg / ml, 0.5mg / ml, 0.1mg / ml, 0.05mg / ml or 0.01mg / ml

[0096]

[0097]

[0098] Preparation method: After thawing the concentrated FP3 fusion protein stock solution after changing the liquid, in a clean bench (sterile cabinet) of class C, add filter-sterilized solution containing 55mM citric acid, 12.5% ​​sucrose, 250mM Arginine and 0.05% Tween 20 buffer, filter, adjust FP3 fusion protein to 10mg / ml, 9mg / ml, 5mg / ml, 1mg / ml, 0.5mg / ml, 0.1mg / ml, 0.05mg / ml or 0.01mg / ml, pH 7.5-8.3, aseptically dispensed into eye drop containers and stored at 2-8°C.

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Abstract

The invention relates to an eye drop containing a VEGF antagonist. The eye drop contains the low-concentration VEGF antagonist, and especially contains the 0.05-9.0mg / ml VEGF antagonist. The eye drop can ensure the safety and the stability, and simultaneously has substantial curative effects.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to an eye drop containing a VEGF antagonist. Background technique [0002] The incidence of ocular surface diseases such as corneal neovascularization, neovascular glaucoma, pterygium, and chronic conjunctivitis has a certain relationship with the generation of neovascularization. Overexpression of VEGF can induce ocular surface neovascularization. Corneal neovascularization is not an independent corneal disease, but a pathological change. There are many reasons for corneal neovascularization, such as immune inflammation, infection, degeneration, trauma, improper use of contact lenses, and iatrogenic diseases. If the corneal neovascularization caused by the above reasons is not treated in time, it will eventually lead to corneal blindness. Corneal neovascularization is the main cause of vision loss and blindness worldwide. About 4.14% of ophthalmic patients in the United...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K39/395A61K9/08A61K47/34A61P27/02A61P27/06
CPCA61K9/0048A61K9/08A61K39/3955A61K47/12A61K47/183A61K47/26
Inventor 柯潇郑强
Owner CHENGDU KANGHONG BIOTECH
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