Magnetic water-soluble fullerene, and preparation method and application thereof
A fullerene, water-soluble technology, applied in the field of medicine, can solve the problems of poor targeting, weak water-solubility of fullerene, low biocompatibility, etc., and achieves low cost, good physical and chemical stability, and water dispersion. strong effect
Examples
preparation example Construction
[0013] The preparation method of described magnetic water-soluble fullerene is realized by the following steps:
[0014] 1) Dissolve 100 mg of fullerene in 100 ml of toluene, add 0.5 g of sodium hydride, stir evenly, add 0.3 ml of diethyl bromomalonate, protect with nitrogen, stir at room temperature 15-25°C for 5 hours, filter to remove sodium hydride, Toluene was removed by rotary evaporation, and vacuum-dried at 60°C for 24 hours to obtain a fullerene substituted with diethyl bromomalonate;
[0015] 2) Add 1 g of the above-mentioned fullerene substituted by diethyl bromomalonate and sodium hydride into 50 ml of toluene, hydrolyze at 80 ° C until the toluene phase is colorless, pour off the toluene, add 20 ml of concentrated hydrochloric acid, filter to obtain a filter cake, and take The filter cake was dissolved in 100ml of methanol, filtered to remove insoluble matter, methanol was removed by rotary evaporation, and vacuum-dried at 60°C for 24 hours to obtain malonate-subs...
Embodiment 1
[0043] 1) Dissolve 100 mg of fullerene in 100 ml of toluene, add 0.5 g of sodium hydride, stir evenly, add 0.3 ml of diethyl bromomalonate, protect with nitrogen, stir at room temperature 15-25°C for 5 hours, filter to remove sodium hydride, Toluene was removed by rotary evaporation, and vacuum-dried at 60°C for 24 hours to obtain a fullerene substituted with diethyl bromomalonate;
[0044] 2) Add 1 g of the above-mentioned fullerene substituted by diethyl bromomalonate and sodium hydride into 50 ml of toluene, hydrolyze at 80 ° C until the toluene phase is colorless, pour off the toluene, add 20 ml of concentrated hydrochloric acid, filter to obtain a filter cake, and take The filter cake was dissolved in 100ml of methanol, filtered to remove insoluble matter, methanol was removed by rotary evaporation, and vacuum-dried at 60°C for 24 hours to obtain malonate-substituted fullerene (C 60 -COOH) 84mg.
[0045] 3) Fully dissolve 50 mg of the above malonic acid-substituted fulle...
Embodiment 2
[0048] 1) Dissolve 100 mg of fullerene in 100 ml of toluene, add 0.5 g of sodium hydride, stir evenly, add 0.3 ml of diethyl bromomalonate, protect with nitrogen, stir at room temperature 15-25°C for 5 hours, filter to remove sodium hydride, Toluene was removed by rotary evaporation, and vacuum-dried at 60°C for 24 hours to obtain a fullerene substituted with diethyl bromomalonate;
[0049] 2) Add 1 g of the above-mentioned fullerene substituted by diethyl bromomalonate and sodium hydride into 50 ml of toluene, hydrolyze at 80 ° C until the toluene phase is colorless, pour off the toluene, add 20 ml of concentrated hydrochloric acid, filter to obtain a filter cake, and take The filter cake was dissolved in 100ml of methanol, filtered to remove insoluble matter, methanol was removed by rotary evaporation, and vacuum-dried at 60°C for 24 hours to obtain malonate-substituted fullerene (C 60 -COOH) 86mg.
[0050] 3) Fully dissolve 50 mg of the above malonic acid-substituted fulle...
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Abstract
Description
Claims
Application Information
- IPC
- A61K49/06; A61K41/00; A61K47/32; A61K47/34; A61K47/02; A61K47/04; A61P35/00
- Inventors
- 史进进; 余晓媛