Chinese medicine composition for treating diabetes mellitus

A composition and diabetes technology, applied in drug combination, metabolic disease, pharmaceutical formula, etc., can solve problems such as poor treatment effect, inability to give detailed solutions, single treatment level, etc., to achieve reliable efficacy and excellent inhibition rate intensity , improve the effect of complications

Inactive Publication Date: 2013-08-14
CHANGCHUN UNIV OF CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, only taking a single medicinal material has the disadvantages of single treatment level and poor treatment effect.
[0007] In the current prior art, there are drugs that use the combination of total alkaloids and total ginseng saponins to treat diabetes, but they cannot provide detailed solutions for determining the optimal therapeutic dosage and ensuring the accurate dosage

Method used

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  • Chinese medicine composition for treating diabetes mellitus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The first step, the extraction of total ginseng saponins: take 1 g of ginseng powder after sieving, put it in a Soxhlet extractor, add chloroform and heat to reflux for 3 hours, discard the chloroform liquid, evaporate the solvent from the dregs, and put it together with the filter paper tube Move it into an Erlenmeyer flask, accurately add water to saturate it with n-butanol, seal it tightly, place it for 12 hours, treat it with ultrasonic waves with a power of 250W and a frequency of 50Hz for 30 minutes, filter, and discard the initial filtrate to obtain total ginsenosides.

[0031] Extraction of the total alkaloids of Coptis chinensis: Take the whole plant of Coptis chinensis, crush it into a coarse powder, add 10 times the mass fraction of 0.5% sulfuric acid aqueous solution, soak and extract at room temperature for 24 hours, and filter three times; take the extract and add lime milk to adjust the pH to 7, place After 10 hours, filter, take the extract and add concen...

Embodiment 2

[0034] In the first step, total ginsenosides and total alkaloids of Coptis chinensis are extracted, and the process is as described in Example 1.

[0035] The second step is to make ginseng and berberine tablets: take 10 g of total ginseng saponins and 40 g of total alkaloids of berberine, mix them with 40 g of starch, granulate with 80% ethanol, dry, compress into tablets, and coat with film to obtain 1000 tablets.

Embodiment 3

[0037] In the first step, total ginsenosides and total alkaloids of Coptis chinensis are extracted, and the process is as described in Example 1.

[0038] The second step is to make Shenlian granules: take 20g of total ginsenosides, 80g of total alkaloids of coptis, add 80g of dextrin, 80g of soluble starch, and 2g of stevioside, mix well, add 700ml of distilled water, stir to dissolve, and make it with 80% ethanol granules, dried and packaged to obtain the Shenlian granules of the present invention.

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Abstract

The invention discloses a Chinese medicine composition for treating diabetes mellitus, belonging to the field of research of traditional Chinese medicines. The Chinese medicine composition comprises 1-25 parts by mass of total saponins of panax ginseng and 4-100 parts by mass of total alkaloids of coptis chinensis. The invention further provides a specific preparation method of the total saponins of panax ginseng and the total alkaloids of coptis chinensis of the Chinese medicine composition. According to the Chinese medicine composition, the preparation method is explicit, the effectiveness reliability of traditional Chinese medicines is ensured, the diabetes mellitus and caused complications are remarkably improved and treated, the activity of alpha-glucosidase is inhibited, and the inhibition rate strength of the Chinese medicine composition is better than that of acarbose.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine development and relates to a traditional Chinese medicine composition for treating diabetes. Background technique [0002] Diabetes is a combination of sugar, protein, fat, water and electrolytes caused by genetic factors, immune dysfunction, microbial infection and its toxins, mental factors and other pathogenic factors acting on the body to cause insulin dysfunction and insulin resistance. A series of metabolic disorder syndromes are clinically characterized by hyperglycemia. Typical cases may present with symptoms such as polyuria, polydipsia, polyphagia, and weight loss. Type 1 diabetes and type 2 diabetes are common, and type 2 diabetes accounts for more than 95%. In developed countries, nearly 10% of people over 60 years old are diabetic patients; in China, diabetes patients account for more than 5% of people over 60 years old. Diabetes has attracted worldwide attention as a pot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/718A61K36/258A61P3/10
Inventor 张辉唐珊林喆孙佳明李娜刘冬
Owner CHANGCHUN UNIV OF CHINESE MEDICINE
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