Refining method of erythromycin thiocyanate

A technology of erythromycin thiocyanate and its refining method, which is applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc., and can solve the problems of not providing refined erythromycin thiocyanate, etc.

Active Publication Date: 2013-09-04
NINGXIA QIYUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This invention patent is innovative, but its refining method starts from the crude product of erythromycin thiocyanate, and does not provide a method for extracting refined erythromycin thiocyanate from the erythromycin filtrate, which has certain limitations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Take 50L of erythromycin filtrate, and use Cationic 600 flocculant to decolorize and remove impurities from the erythromycin filtrate. The amount of flocculant used is 0.4%. The light transmittance before treatment is 3.1%, the light transmittance of the filtrate after treatment is 15.7%, the protein content before treatment is 34.6mg / 100ml, and the protein content after treatment is 11.5mg / 100ml. The impurity-removed erythromycin filtrate is extracted with a special organic solvent for erythromycin, and the obtained erythromycin extract is further decolorized and impurity-removed with activated carbon. The amount of activated carbon used is 0.4%. Process control PH: 9.0, temperature: 35°C, potency of the extract: 15000u / ml; the light transmittance of the erythromycin extract before treatment was 39.8%, the light transmittance after treatment was 77.4%, and the protein content before treatment was 6.4% mg / 100ml, the protein content after treatment is 0.9mg / 100ml. The ...

Embodiment 2

[0019] Take 50L of erythromycin filtrate, and use cationic 600 flocculant to decolorize and remove impurities on the erythromycin filtrate, the usage of flocculant is 1%. The light transmittance before treatment was 2.4%, the light transmittance of the filtrate after treatment was 13.6%, the protein content before treatment was 28.7mg / 100ml, and the protein content was 14.5mg / 100ml. The impurity-removed erythromycin filtrate is extracted with a special organic solvent for erythromycin, and the obtained erythromycin extract is further decolorized and impurity-removed with activated carbon. The amount of activated carbon used was 1%. Process control PH: 9.5, temperature: 30°C, extract potency: 30000u / ml; the light transmittance of the erythromycin extract before treatment is 37.6%, the light transmittance after treatment is 80.2%, and the protein content before treatment is 5.7% mg / 100ml, the protein content after treatment is 1.6mg / 100ml. The treated erythromycin extract was ...

Embodiment 3

[0021]Take 50L of erythromycin filtrate, and use cationic 600 flocculant to decolorize and remove impurities on the erythromycin filtrate, the usage of flocculant is 1.5%. The light transmittance before treatment is 3.7%, the light transmittance of the filtrate after treatment is 16.7%, the protein content before treatment is 27.5mg / 100ml, and the protein content is 15.7mg / 100ml. The impurity-removed erythromycin filtrate is extracted with a special organic solvent for erythromycin, and the obtained erythromycin extract is further decolorized and impurity-removed with activated carbon. The amount of activated carbon used is 1.5%. Process control PH: 10.5, temperature: 45°C, potency of the extract: 40000u / ml; the light transmittance of the erythromycin extract before treatment was 37.4%, the light transmittance after treatment was 78.7%, and the protein content before treatment was 6.2% mg / 100ml, the protein content after treatment is 1.1mg / 100ml. The treated erythromycin ext...

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Abstract

The invention provides a refining method of erythromycin thiocyanate. The refining method of the erythromycin thiocyanate mainly comprises the following steps of: (1), preliminarily discoloring erythrocin filtrate by a flocculating agent to remove impurities, extracting the purified solution by a special-purpose erythromycin solvent, and further discoloring the extracting solution by active carbon to remove impurities; and (2), inverting the treated erythrocin extracting solution to a purifying water phase by phase inversion, extracting the thiocyanate in the water phase to a solvent mixture of n-butyl acetate and cyclohexane, thereby obtaining an erythrocin crystallization solution by utilizing a two-step crystallization method, and separating and drying to obtain an erythromycin thiocyanate finished product. The content of erythrocin A in the finished product is more than 83%. In order to solve the defect that the content of erythrocin A in the erythromycin thiocyanate finished product, which is prepared by extracting the erythrocin from erythrocin filtrate by utilizing special-purpose solvent, crystallizing the extracting solvent and finally separating and drying in a conventional production process, is low, the refining method of the erythromycin thiocyanate can be used for improving the content of the erythrocin A in the erythromycin thiocyanate finished product by discoloring the filtrate and the extracting solution to remove impurities and adopting a two-step crystallizing process after phase inversion.

Description

technical field [0001] The invention belongs to the technical field of biology and new medicine, in particular to a method for extracting crystal erythromycin thiocyanate from erythromycin filtrate, in particular to a refining method for erythromycin thiocyanate. Background technique [0002] Erythromycin thiocyanate is the thiocyanate salt of erythromycin. It is the basic raw material of domestic erythromycin derivative products such as roxithromycin, erythromycin ethylsuccinate, azithromycin, and clarithromycin. Due to the large number of clinical applications of erythromycin and its derivatives and downstream products, it has become the third largest drug in the world antibiotic market. Therefore, the corresponding basic raw materials also have a broad market space. The main active ingredient of erythromycin is erythromycin A, and the main impurities are erythromycin B, erythromycin C, erythromycin D, erythromycin E, and erythromycin F. The higher the content of erythro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/08C07H1/06
Inventor 孙瑞君李泉山张志
Owner NINGXIA QIYUAN PHARMA
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