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3D-printing fast forming method of nano composite degradable bone repair material

A nano-composite, three-dimensional printing technology, applied in bone implants, medical science, prostheses, etc., can solve the problems of insufficient mechanical strength and strength retention time, inability to synthesize bone repair materials, and acid degradation products, etc. Fast speed, good effect, simple operation effect

Inactive Publication Date: 2013-09-11
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although polylactic acid has good biocompatibility and degradable absorbability, there are several problems at the same time: first, the degradation product is acidic, which is easy to cause non-infectious inflammation; second, as a bone repair material, its mechanical strength and strength maintenance not enough time
[0005] Because the shape, size, and composite concentration of materials are different for different people, the technology at this stage is still unable to synthesize different bone repair materials for different situations.

Method used

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  • 3D-printing fast forming method of nano composite degradable bone repair material

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Embodiment 1

[0036] Such as figure 1As shown, it is a flow chart of a specific embodiment of a preparation method for three-dimensional printing rapid prototyping of a nanocomposite degradable bone repair material in the present invention. see figure 1 The specific steps of the preparation method of a nanocomposite degradable bone repair material for three-dimensional printing rapid prototyping in this embodiment include:

[0037] S101. Using computer-aided design software to design a personalized three-dimensional structure model of the bone repair material; wherein, the computer-aided design software can use solidworks software, and of course other software that can realize the above functions can also be used.

[0038] S102. Import the designed 3D structural model into the 3D printer;

[0039] S103. placing the synthesized nanocomposite degradable bone repair material on the three-dimensional printer;

[0040] S104. Start the three-dimensional printer to complete the layer-by-layer p...

Embodiment 2

[0048] In this example, polylactic acid is used as the degradable bone repair polymer, and a composite material of polylactic acid and nano-hydroxyapatite is prepared by melt blending as follows:

[0049] Nano-hydroxyapatite particles are added to polylactic acid, blended under the condition of 120-150°C higher than the glass transition temperature of polylactic acid, and the nano-hydroxyapatite particles are compounded into the polylactic acid matrix by mechanical force.

Embodiment 3

[0051] This embodiment realizes the preparation of a simple solid bone screw, and the specific steps are as follows:

[0052] (1) Design of 3D structure of simple solid bone screw

[0053] Using the computer-aided design software solidworks to design a simple solid bone screw three-dimensional structure model, such as figure 2 As shown in a; during the design, the three-dimensional structure model of the simple solid bone screw is individually configured. For example, the parameters of the simple solid bone screw are set as follows: the screw diameter is designed to be 8mm, the screw length is designed to be 40mm, the pitch is designed to be 2mm, and the thread depth Designed to be 1.5mm.

[0054] Save the 3D structure model of the designed simple solid bone screw as a file in STL format, such as figure 2 As shown in b, it is a schematic diagram of a simple solid bone screw in the engineering drawing format displayed in the STL format file.

[0055] (2) Printing of simple...

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Abstract

The invention relates to the field of bone repair material production, in particular to a 3D-printing fast forming method of nano composite degradable bone repair material. The method includes: designing a personal bone repair material 3D-structure model by computer-assisted design software; importing the designed 3D-structure model to a 3D printer; placing the synthetized nano composite degradable bone repair material on the 3D printer; and starting the 3D printer to print the bone repair material layer by layer. The method has the advantages that the personal bone repair material is printed with the 3D printer, the problem that the traditional production method fails in forming special shapes with high precision is solved, the bone repair material has better effect of repairing bones at special parts, the precision is higher, and the method is more applicable to clinical applications.

Description

technical field [0001] The invention relates to the field of preparation of bone repair materials, more specifically, to a preparation method for three-dimensional printing rapid prototyping of nanocomposite degradable bone repair materials. Background technique [0002] As the largest tissue and organ in the human body, bone bears important responsibilities for life activities, but it is also the most prone to defects. Bone defect is a common clinical disease, and it is also one of the difficult problems in orthopedic treatment. Every year, millions of patients with bone tissue defects undergo surgery. In China, a country with a large population, it is estimated that more than 3 million people suffer from bone defects or dysfunction every year due to traumatic fractures, spinal degenerative diseases, tumors, bone tuberculosis and other orthopedic diseases caused by traffic accidents and production safety accidents. Bone grafts have become the most in-demand graft after bl...

Claims

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Application Information

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IPC IPC(8): A61F2/28A61L27/18A61L27/12
Inventor 张超李晓琼李皓刘奕夫吴华德蒋庆
Owner SUN YAT SEN UNIV
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