Sarpogrelate hydrochloride sustained release preparation and preparation method thereof

A technology of sarcogrelate hydrochloride and preparations, which is applied in the field of sarcogrelate hydrochloride, can solve the problems of patient burden, foreign body sensation and rupture in the body, and achieve the effects of delaying drug release, preventing vasoconstriction, and antithrombotic vasoconstriction

Inactive Publication Date: 2013-09-11
锦华制药株式会社
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the device is in contact with the body or inserted into the body, the body is prone to a foreign body sensation or even breaks, causing a certain burden on the patient

Method used

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  • Sarpogrelate hydrochloride sustained release preparation and preparation method thereof
  • Sarpogrelate hydrochloride sustained release preparation and preparation method thereof
  • Sarpogrelate hydrochloride sustained release preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～3

[0019] Examples 1-3 are for comparing the effects of different types of water-soluble polymers on drug release. It is made by dry granulation and tabletting.

[0020] Mix sarcogrelate hydrochloride and water-soluble polymer (hydroxypropyl methylcellulose, or carbo, polyethylene oxide), lactose, hydroxyethylcellulose in a mixer for 5 minutes and then dry granulate (GL -25B, pioneered in Zhangjiagang). Magnesium stearate was added to the prepared granules and mixed for 3 minutes to obtain the final blend. Tablets were compressed on a rotary tablet press (KT-1000) to obtain tablets of 8 to 20 kgf.

[0021] The composition of table 1 embodiment 1~3

[0022] Raw material name

Embodiment 4～6

[0024] Examples 4-6 In order to evaluate the effect of different drug releases, hydrophilic hydroxypropyl methylcellulose, polymers of different viscosities and different grades of displacing agents were used. The manufacturing method is wet granulation.

[0025] First, hydroxypropyl methylcellulose was dissolved in absolute ethanol to obtain a mixed solution. In addition, sarcogrelate hydrochloride, hydroxypropyl methylcellulose, and lactose were rotated and stirred at a high speed. After standing for 5 minutes, a mixed solution was obtained. Then slowly add the previously configured mixture, mix and granulate. The prepared medicine granules are dried for 4 hours under the condition of 60 degrees to obtain the medicine granules with a dry weight below 2%. Finally, after screening, 1 mm pellets were obtained. Then the granules are placed in the mixer, magnesium stearate is added, mixed for 3 minutes, and compressed with a rotary tablet machine to obtain tablets of 8 to 20 kg...

Embodiment 7～8

[0029] Examples 7-8 are comparative formulations made in order to evaluate the effect of the added amount of hydroxypropyl methylcellulose on drug release.

[0030] The manufacturing method is the same as in Examples 4-6.

[0031] The composition of table 3 embodiment 7~8 (unit: mg / T)

[0032]

[0033] Dissolution rate evaluation

[0034] The target dissolution rate of the sustained-release preparation is defined through pharmacokinetic characteristics and literature materials, 10-40% in 4 hours, 40-70% in 10 hours, and more than 80% in 24 hours. Taking Anplag (sargrelate hydrochloride 100mg) produced by YUHAN Company, which is on the market for trial sale, as an example, the dissolution test was carried out together with each example tablet according to the following dissolution test conditions stipulated in Article 1 of the dissolution test method in the general test method of the Korean Pharmacopoeia , compared to the target dissolution rate. At the same time, during ...

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PUM

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Abstract

The invention relates to a sarpogrelate hydrochloride sustained release preparation and a preparation method thereof. The sarpogrelate hydrochloride sustained release preparation provided by the invention is invented for slowing down the release speed of a sarpogrelate hydrochloride medicine. The main components of the preparation provided by the invention can release medicines continuously in the gastrointestinal tract for over 24 hours.

Description

technical field [0001] The present invention utilizes sarcogrelate hydrochloride which has antithrombotic and vasoconstriction effects, and by using hydrophilic and hydrophobic carriers, its drug release speed is delayed, and the release time of sarcogrelate hydrochloride can be extended to 20-24 hours or above. Background technique [0002] The release technology of the drug of the present invention is a well-known method of compressing a hydrophilic or hydrophobic polymer together with the drug, and compressing the drug after wet granulation. It has also been mentioned in many patents and papers that water-soluble polymer cellulose derivatives, shellac, zein and other slow-release preparations are used, and the main components of tablets such as medicinal pellets and cores are used to make coating coatings, and then use Insoluble cellulose derivatives, plasticizers such as polyacrylic acid and other additives are coated, dried, and sustained release methods. [0003] The...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/225A61K47/32A61K47/34A61K47/36A61K47/38A61P7/02A61P9/00
Inventor 崔载胜南庚太金志太朴宗洙
Owner 锦华制药株式会社
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