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Traditional Chinese medicine monomer composition for preparation of drugs used for treating polycystic ovarian syndrome and preparation method thereof

A technology of monomer composition and polycystic ovary, which is applied in the preparation of traditional Chinese medicine monomer composition for treating polycystic ovary syndrome. No side effects and other problems, to achieve the effect of small side effects, low toxicity, and promote follicle maturation

Active Publication Date: 2013-09-11
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0014] The purpose of the present invention is to disclose the application of a traditional Chinese medicine monomer composition (composed of cryptotanshinone, baicalin, and quercetin) in the preparation of drugs for the treatment of polycystic ovary syndrome, so as to meet the needs of clinical application and overcome the existing technical problems. There is no ideal drug for the treatment of polycystic ovary syndrome in China, and the drug has relatively high toxicity and side effects, which cannot be used for a long time and has some defects of poor safety.

Method used

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  • Traditional Chinese medicine monomer composition for preparation of drugs used for treating polycystic ovarian syndrome and preparation method thereof
  • Traditional Chinese medicine monomer composition for preparation of drugs used for treating polycystic ovarian syndrome and preparation method thereof
  • Traditional Chinese medicine monomer composition for preparation of drugs used for treating polycystic ovarian syndrome and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0035] The animal model of polycystic ovary syndrome was prepared by using Wister rats, and the successful models were given drug intervention. ELISA, RT-PCR and other methods were used for detection, and statistical software SPSS16.0 was used for analysis to clarify the therapeutic effect and possible mechanism of baicalin on animal models of polycystic ovary syndrome.

[0036] 1. Materials

[0037] 1.1 Experimental animals

[0038] 190 21-day-old SPF-grade female Wister rats were provided by Shanghai Slack Experimental Animal Co., Ltd., and were bred in the Animal Center of the Sea Medicine Department of the Second Military Medical University. 25 ℃ constant temperature (50% humidity) clean-grade breeding, without feeding vitamin products, 12h light and 12h dark cycle alternately.

[0039] 1.2 Main reagents

[0040] Dehydroepiandrosterone (DHEA), sesame oil, and quercetin were all purchased from Sigma, Cryptotanshinone was purchased from Shanghai Tongtian Biotechnology Co....

Embodiment 2

[0083] Prescription: Take the traditional Chinese medicine monomer composition: cryptotanshinone 0.3g, baicalin 2.2g, quercetin 1.0g, add starch 8g, microcrystalline cellulose 2g, magnesium stearate 0.2g, mix evenly, adopt known in the art Method, made into tablets, capsules or granules.

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Abstract

The invention discloses a traditional Chinese medicine monomer composition for preparation of drugs used for treating polycystic ovarian syndrome. The invention is characterized in that the traditional Chinese medicine monomer composition comprises, by mass, 2 to 4% of cryptotanshinone, 13 to 18% of baicalin, 7 to 10% of quercetin and 65 to 80% of adjuvants, wherein the percentages of the above-mentioned components sum to 100%. According to results of in vivo experiments, combined application of the three traditional Chinese medicine monomers consisting of cryptotanshinone, baicalin and quercetin exerts an obvious therapeutic effect on the polycystic ovarian syndrome of a rat model and can substantially increase the level of androgen, promote maturation of ovarian follicles and induce ovulation. More importantly, the three traditional Chinese medicine monomers have no toxicity to the liver and the kidney, little side effects and incomparable security. Thus, the traditional Chinese medicine monomer composition provided by the invention can be used for preparing the drugs used for treating the polycystic ovarian syndrome and has good prospects.

Description

technical field [0001] The invention belongs to the field of pharmacy, and relates to a traditional Chinese medicine monomer composition for treating polycystic ovary syndrome; in addition, the invention also relates to a preparation method and a medical application of the traditional Chinese medicine monomer composition. Background technique [0002] Cryptotanshinone (Cryptotanshinone) is a fat-soluble diterpenoid extracted from the dry root and rhizome of the plant Salvia miltiorrhiza in the Labiatae family. Its molecular formula is C 19 h 20 o 3 , molecular weight: 296.35, structural formula: [0003] [0004] Modern pharmacological studies have shown that cryptotanshinone has antibacterial, anti-oxidant, and anti-aging functions, and has certain curative effects on the treatment of coronary heart disease, angina pectoris, and myocardial damage. Another study shows that cryptotanshinone can inhibit the expression of androgen, and can be used to treat diseases relate...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K9/20A61K9/16A61P15/00A61K31/352A61K31/58
Inventor 俞超芹俞瑾翟乐霞韩洁白玲玲张丹英周丽虹王针织孙帅
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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